Karolinska Institutet

Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors

Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline...

Trajectories of refraction and strabismus from 2.5 to 12 years in a national cohort of extremely preterm children‐ the Extremely Preterm Infants in Sweden Study (EXPRESS)

Abstract Purpose To investigate the longitudinal development of refraction and strabismus in a national cohort of children born extremely preterm (EPT) and find relations to perinatal events and neurodevelopmental outcomes. Methods All surviving children born <27‐gestation wee...

Association of baseline and cumulative cholesterol–high-density lipoprotein–glucose index with cardiometabolic multimorbidity: prospective evidence from two cohort studies

Abstract Introduction Cardiometabolic multimorbidity (CMM) is increasingly common and carries substantial clinical and public-health burden. The cholesterol-high-density lipoprotein-glucose (CHG) index has been linked to adverse cardiometabolic outcomes, but prospective evidence...

Gemfibrozil promotes longevity and health by restricting amino acid uptake through the Dipeptide transporter, PEPT1

The FDA-approved fibrate, gemfibrozil, has been used clinically to treat hyperlipidaemia, showing efficacy both in lowering triglycerides and increasing high-density lipoproteins. However, in recent years, the drug has been increasingly investigated for potential clinical use in...

Mobile genetic elements as strain-specific markers: a case study in Shewanella sp. Pdp11

Abstract Strain-level identification is a key challenge in microbiology, particularly for monitoring microorganisms of interest such as probiotics. Traditional methods based on 16S rRNA gene sequencing often lack the resolution to discriminate closely related strains. This study...

Dysregulated lncRNAs are associated with the progressive arterial phenotype in Hutchinson–Gilford Progeria Syndrome

Hutchinson–Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by de novo LMNA mutations. Patients develop severe systemic symptoms limiting life quality and ultimately causing death from cardiovascular events. Despite extensive research, treatment options...

Enzymatic degradation of conjugated polymer thin films for electrochemical transistors

Degradable imine linkers within the polymer backbone enabled acid-triggered organic mixed ionic–electronic conductors (OMIECs). Yet, for many bioelectronic applications, OMIECs must work in direct contact with physiological fluids, making it challenging to achieve both excellent...

Associations between organizational readiness and implementation fidelity in national implementation of WHO’s labour care guide in Sweden: a prospective observational study

Abstract Background During 2024 and 2025, an adapted version of the World Health Organization’s Labour Care Guide was implemented in approximately half of Sweden’s labor wards within the PICRINO trial. Organizational readiness is widely regarded as a key determinant of successful...

Resilience and adaptation of cancer screening programs to external crises

Objectives To examine how cancer screening programs resumed during the COVID-19 pandemic, focusing on their resilience in terms of coordination, communication, recovery, participation rates, catch-up efforts, inequities, and preparedness. Setting Cancer screening programs represe...

Association of salivary matrix metalloproteinase-8 with metabolic syndrome in women at high GDM risk

Abstract Background To assess associations between metabolic syndrome (MetS), insulin resistance, and periodontal diseases with salivary active matrix metalloproteinase-8 (aMMP-8) in metabolically high-risk women. Methods A total of 112 women with a history of high gestational di...

Extra-Endocrine Features in Infancy as Early Clues to MEN2B

Multiple endocrine neoplasia type 2B (MEN2B) is a rare autosomal-dominant cancer predisposition syndrome in which prognosis is strongly influenced by the stage of medullary thyroid carcinoma at diagnosis. Virtually all affected children exhibit 1 or more extra-endocrine features...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

One in seven has severe pain: a point-prevalence study of hospitalised patients across Africa

ABSTRACT: Acute pain in hospitalised patients is common, yet African data are scarce. We conducted a prospective point-prevalence study of hospitalised adult patients across Africa to determine acute pain prevalence and severity and investigate associations of pain with critical...

Sleep disturbances as early indicators of incident psychiatric disease

PURPOSE: Sleep disturbances are common in individuals with psychiatric diseases and may emerge years before diagnosis. It remains unclear whether they reflect modifiable risk factors or early manifestations of psychiatric illness. We aimed to investigate how different sleep dimen...

Prognostic significance of isolated tumor cells and nodal tumor burden in endometrial cancer: a population-based cohort study

BACKGROUND AND PURPOSE: Since the introduction of sentinel lymph node biopsy, nodal assessment has expanded to nearly all women with endometrial cancer. However, evidence on the prognostic significance of isolated tumor cells (ITCs) and nodal tumor burden remains limited. We ther...

Occupational exposure to noise and depression incidence: a nationwide cohort study of workers in Denmark, 2000–2017

Objectives Research on the association between occupational noise and incident depression is limited. We investigated whether long-term occupational noise was associated with depression risk, both independently and in combination with other stress-related factors. Methods In a Da...

Treatment Preferences in Acute Allergic Reactions—How Can the Context Impact the Preference for a Corticosteroid Mouth Film Versus Conventional Tablets?

Background: The objective was to assess how preferences for a self-dissolving dexamethasone mouth film versus conventional tablets for acute allergic reactions may vary according to population characteristics and the level of outcome knowledge for the intervention (i.e., ex ante,...

Universalism and its Others: Transcultural psychiatry and Swedish exceptionalism after 1945

This article traces the historical development of transcultural psychiatry in Sweden from the post-Second World War period to the early 21st century. It argues that the field emerged at the intersection of welfare universalism, humanitarian internationalism, and clinical encounte...

Problem gambling and affected others: health, relational and economic outcomes across longitudinal trajectories in a population-based Swedish study

Abstract Background Exposure to another person’s gambling problems has been linked to a range of adverse outcomes among affected others (AOs); however, most evidence is based on cross-sectional studies. Less is known about how such outcomes vary over time and across different pat...

Reexamining the Association of Cardiovascular Disease With Neurodevelopmental Disorders in Offspring—Reply

In Reply We thank Dr Karachaliou for her thoughtful comments regarding our study1 investigating whether parents of children with neurodevelopmental disorders (NDDs) have an increased risk of cardiovascular disease (CVD). We appreciate the opportunity to share our view on the poin...