Johns Hopkins University

Association between self-reported oral health issues and autoimmune diseases: evidence from UK biobank

Oral microbiome dysbiosis may contribute to autoimmune disease development, but epidemiological evidence linking oral health and autoimmune disease risk is limited. To evaluate the association between self-reported oral health issues by questionnaire—defined as the presence of pa...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Identificationof the Site of the Fe–S Clusterin CPSF30 via Metal-Coupled Oxidation-Mass Spectrometry

Abstract Cleavage and polyadenylation specificity factor 30 (CPSF30) is a zinc finger protein that plays a key role in pre-mRNA processing by recognizing specific AU-rich sequence elements to facilitate polyadenylation. CPSF30 contains five highly conserved domains made up of thr...

Integrative multiomic analysis identifies transcription factors and target proteins in renal cell carcinoma

Abstract Renal cell carcinoma risk is partly shaped by germline genetic variants that often reside in regulatory regions. However, the transcription factors (TFs) and downstream proteins via which they shape RCC susceptibility remain incompletely characterized. Here we show that...

Going with the flow to solve for symmetry-driven PDE dynamics with physics-informed neural networks

We address a computational framework that integrates symmetry reduction into Physics-Informed Neural Networks (PINNs) for analysing symmetry-driven dynamics in nonlinear partial differential equations (PDEs). Using an auxiliary network to learn time-dependent transformations, we...

Congenital heart disease in pregnancy and severe maternal morbidity: A distributed data network study

Abstract Introduction Pregnant people with congenital heart disease (CHD) are a growing patient population in obstetrics, yet evidence on the risk for severe maternal morbidity (SMM) has largely been limited to studies that lack specificity for CHD. We conducted this study to dem...

Multiple micronutrient supplements (MMS) for adolescent girls: are we getting carried away by the hype?

Multiple micronutrient supplements (MMS) during pregnancy have gained attention in recent years due to growing evidence that they are more effective than iron and folic acid (IFA) supplements in preventing preterm birth and low birth weight. So, should MMS also replace weekly iro...

Infertility service availability, geographic accessibility, and use: results from linked facility-female cross-sectional data in Burkina Faso, Côte d’Ivoire, Niger, and Uganda

Abstract Background Infertility affects millions of people globally, with the highest prevalence in Africa (16%). Despite strong evidence linking sexually transmitted infections (STIs) to infertility in sub-Saharan Africa, evidence on the availability of and accessibility to infe...

How Equity and Quality Are Considered by Cancer Centers Offering Practice-Integrated Telehealth Visits: A Qualitative Study

INTRODUCTION: The COVID-19 pandemic forever changed health care delivery and led to a rapid uptake in telehealth visits. However, the quality and equity of these visits compared to in-person visits are unknown. This analysis interviewed oncology practitioners to understand how US...

Racial microaggressions in prenatal care settings and perceived quality of prenatal care among Black/African American women

In the United States, Black/African American (AA) women face significant health disparities, including higher rates of Adverse Pregnancy Outcomes (APOs). This is despite increased utilization of prenatal care (PNC) over time, which is a critical intervention for identifying and m...

Diagnostic Value of Multiplane Tool in Virtual Lesion Confirmation in Augmented Fluoroscopy-Guided Navigational Bronchoscopy for Peripheral Pulmonary Lesions

BACKGROUND: The demand for minimally invasive diagnostic techniques for peripheral pulmonary lesions (PPL) is rising. Augmented fluoroscopy (AF) provides real-time guidance by overlaying CT-derived virtual targets onto fluoroscopic images, yet its diagnostic value remains poorly...

Ruling In and Ruling Out Sepsis Using Likelihood Ratios of a Host Response Assay

Overview: SeptiCyte RAPID is an FDA-cleared gene expression test that quantifies host immune response to aid in the diagnosis of sepsis. The test yields a score (the SeptiScore) ranging from 0–15, distributed across four bands (1–4) based on increased likelihood of sepsis. Each b...

Development and validation of a theoretical test for ultrasound-guided biopsy competence in the head and neck

PURPOSE: This prospective study is designed to test the validity of a multiple-choice question (MCQ) test in assessing theoretical knowledge of ultrasound-guided fine-needle aspiration biosy and core-needle biopsy of the head and neck. METHODS: Seven international experts reached...

Real-World Safety and Efficacy of Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: A Retrospective Cohort Study of 38 049 Patients

BACKGROUND: Chronic subdural hematoma is a complex but commonly treated neurosurgical condition, particularly affecting the elderly. Traditional treatment involves open surgeries, but middle meningeal artery embolization (MMAE) has emerged as an effective, minimally invasive adju...

Patient engagement, acceptability, and preference of artificial intelligence versus human coaching for diabetes prevention

Artificial intelligence-powered lifestyle interventions may expand access to behavioral change support, but patient experience remains critical to real-world uptake and effectiveness. In a phase 3 randomized clinical trial of adults with prediabetes and overweight or obesity ( N...

Selection in the City: The Supply of Trees to Baltimore’s Urban Forest

Domestic selection creates the assemblages of organisms found in human-dominated environments, and urban forestry is a useful illustration of this process in action. In this study, we aim to understand how the process of domestic selection influences the nursery supply chain of t...

Availability and Quality of Electronic Health Record Data to Track Physical Function Across a Care Transition

ABSTRACT Introduction Physical function (PF) is critical to quality of life and healthcare value, especially for older adults following hospitalization. Monitoring PF supports recovery, reduces adverse events, and improves care transitions. Despite the potential of electronic hea...

Adipose Tissue Browning in MASLD and Its Molecular Mechanisms and Metabolic Crosstalk

PURPOSE OF REVIEW: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly prevalent complication of obesity and metabolic dysregulation, with limited therapies targeting upstream drivers of disease. Adipose tissue has emerged as a central regulator of...

Medicaid Expansion and Firearm Suicide Mortality Among Black and White Men: A State-Level Retrospective Study, United States, 2000-2023.

. 2026;116(8):1095-1103. https://doi.org/10.2105/AJPH.2026.308581).

Schizophrenia Beyond Genome-Wide Association Studies: It’s About Time

The discovery of potentially many hundreds of risk genes for schizophrenia does not resolve the mystery of the illness at the level of an individual. The diversity of implicated gene functions has encouraged speculation that there are convergent biological pathways that mediate r...