Johns Hopkins University

Assessing the impacts of sufficient and reliable electricity in low-resource healthcare facilities

Health systems across sub-Saharan Africa often lack the electricity needed for lighting, medical, diagnostic, and sterilization equipment, and refrigeration. More than one billion people globally rely on facilities with no electricity or a highly unreliable supply. Using survey d...

Age-Friendly Health Systems in Hospital at Home: An Integrated Healthcare System Cross-Sectional Survey

Background Age-Friendly Health Systems (AFHS) is an evidenced-based initiative structured on the 4Ms framework (What Matters, Medications, Mentation, and Mobility) to improve care for older adult patients and has been implemented across the United States in various care settings....

Determinants of Symptom Burden in Non-Dialysis-Dependent Chronic Kidney Disease: A Cross-Sectional Cohort Study

Understanding symptoms experienced by people with non-dialysis-dependent chronic kidney disease (NDD-CKD) may improve person-centered outcomes. We characterized symptom burden in individuals with NDD-CKD by clinical and sociodemographic characteristics. We conducted a cross-secti...

LLM-Generated Visual Summaries of Cochrane Plain-Language Summaries: A Pilot Expert-Rated Study and Implications for Research Communication

Background: Plain-language summaries (PLSs) improve accessibility of medical research for patients but remain predominantly text-based. Large language models (LLMs) can now generate images from text. We carried out the present exploratory study to evaluate whether LLMs can genera...

Perseus: Lineage-Aware Refinement of Kraken2 Taxonomic Classification for Long Read Metagenomes

MOTIVATION: Long-read metagenomic sequencing improves assembly contiguity and enables genome-resolved analysis of complex microbial communities, but accurate taxonomic classification of long reads and assembled contigs remains challenging. Highly scalable k-mer-based classifiers...

Global Variation in Fusion Assessment Practices Following Anterior Cervical Discectomy and Fusion

Study DesignCross-sectional survey.ObjectivesTo characterize global variation in imaging modalities, fusion criteria, and decision-making practices for assessing fusion following anterior cervical discectomy and fusion (ACDF).MethodsA modified 30-item survey using Delphi-informed...

Nontraumatic Osteonecrosis of the Femoral Head: An Update.

➢ Nontraumatic osteonecrosis of the femoral head should be suspected in patients who are <50 years of age who have persistent hip pain despite normal radiographs. ➢ Bilateral involvement is common; magnetic resonance imaging (MRI) of the contralateral hip is recommended. ➢ MRI is...

Factors Associated With Willingness to Support Organ Donation in Trinidad and Tobago

Introduction Organ donation and transplantation remain underutilized in Trinidad and Tobago despite the rising burden of chronic kidney and end-stage renal disease. Limited public understanding, low awareness of existing legislation, and persistent sociocultural and religious con...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Landscape of approaches for streamlining pre-analytical and early analytical variables for solid tumor next-generation sequencing: A Genomics Organization for Academic Laboratories consortium report

The scope of pre-analytical and early analytical methods used in clinical molecular laboratories can have vast effects on the quality and turnaround time for solid tumor next-generation sequencing assays. To learn more about various approaches, a survey of 24 academic laboratorie...

New Annular, Indurated Plaques During Mogamulizumab Therapy in Cutaneous T‐Cell Lymphoma: A Clinicopathologic Pitfall

ABSTRACT New annular, indurated plaques arising during mogamulizumab therapy for cutaneous T‐cell lymphoma (CTCL) present a diagnostic challenge, as they may raise concern for treatment‐related eruption or disease progression. We report two patients with darker skin types who dev...

This Is My Story (TIMS), a Five-Year Thematic Analysis of Patient Narratives from a Novel Intervention in an Academic Hospital

Background/Objective: This is My Story (TIMS) is a patient-centered, interview-based audio narrative program that provides a humanistic intervention to help the medical team understand more information about a patient’s story that is not routinely captured in their medical chart....

Clinical Practice Audit of 60-day Temporary Peripheral Nerve Stimulation

OBJECTIVE: To prospectively evaluate pain relief and functional outcomes through 14 months after 60-day percutaneous peripheral nerve stimulation (PNS) in a consecutive real-world cohort. DESIGN: Prospective single-center observational cohort study of 102 consecutive patients imp...

Immune cell dynamics during compensatory renal hypertrophy after unilateral nephrectomy

The mechanisms underlying compensatory renal hypertrophy (CRH) in living kidney donors after unilateral nephrectomy (UNx) remain complex and underexplored. We examined immune cells involved in CRH after UNx in mice. Following UNx of the left kidney in WT mice, GFR measurements, f...

The Transition of Youth With Diabetes From Pediatric to Adult Diabetes Care Services: A Consensus Report of the Joint Working Group of the International Society for Pediatric and Adolescent Diabetes (ISPAD), the European Association for the Study of Diabetes (EASD), and the American Diabetes Association (ADA)

Young adulthood is a period of significant and unique physiological, psychological, sexual, and social upheaval. Related challenges can have an impact on effective diabetes self-management, with high rates of unplanned health care use recorded for many, and consequent increases i...

UHC Achievement and the Public Sector: A South Asian Perspective

Universal health coverage (UHC) remains a major challenge in South Asia despite substantial improvements in health outcomes, service coverage, and schemes for financial protection. This article examines UHC achievement in Bangladesh, India, Nepal, Pakistan, and Sri Lanka, with pa...

Expansion of the Clinical and Molecular Spectrum of LINS1 ‐Associated Disease

ABSTRACT LINS1 gene plays a role in cognition and brain development. Mutations in this gene have been identified as the cause of a neurodevelopmental disorder as well as dysmorphisms, motor symptoms, behavioral problems, seizures, microcephaly, mitral valve prolapse, and Q‐T prol...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Cannabis use and retention in telemedicine treatment for opioid use disorder: a retrospective cohort study

Cannabis use can be a barrier to treatment for opioid use disorder due to clinic policies in some settings requiring full abstinence to initiate or continue care. Telemedicine represents an important opportunity to expand treatment access. While there is conflicting evidence on t...

Opioid limiting law and opioid prescriptions among Medicaid-enrolled survivors of childhood cancer

Abstract Background Many U.S. states have enacted opioid-limiting laws to curb the opioid epidemic, often capping opioid prescriptions at seven days. How these laws affect opioid prescribing among long-term survivors of childhood cancer remains unclear. Methods Using Medicaid cla...