Johns Hopkins University

Diagnostic and Molecular Yield of a Multidisciplinary Team-Guided Combined Endobronchial and Endoscopic Ultrasound-Guided Sampling Strategy for Mediastinal and Hilar Lymphadenopathy

BACKGROUND: Real-world data examining structured modality selection for mediastinal/hilar adenopathy in mixed malignant and benign cohorts is limited. We evaluated the performance of a multidisciplinary team (MDT)-guided strategy incorporating EBUS/EUS-B and EUS for both benign a...

Prenatal Water Fluoride Exposure and Children’s Behavioral Problems

Importance Although fluoride exposure at high levels during the perinatal period has been associated with socioemotional problems among children, there is limited evidence regarding potential associations at lower levels of fluoride exposure, particularly in the US. Objective To...

Predictive association between control measures and chikungunya fever incidence based on random forest and SHAP analysis

Background Using the 2025 Chikungunya fever (CHIK) outbreak in Chancheng District, Foshan City, this study applied a random forest (RF) regression model combined with SHapley Additive exPlanations (SHAP) to explore predictive associations, nonlinear relationships and potential th...

Analytical design solutions for shear buckling of thin plates with edge-stiffened holes

This paper studies the elastic shear buckling behaviour of cold-formed steel plates with edge-stiffened central holes of three different shapes (circular, square, and diamond) and proposes simplified approximation formulae for design use. The analysis is conducted utilizing the f...

Reframing obesity in aging people with HIV: sarcopenic obesity, muscle quality, and frailty

Purpose of review As people with HIV (PWH) age, obesity is increasingly prevalent, yet body weight alone inadequately captures the functional and metabolic consequences of adverse body composition remodeling. This review examines emerging evidence supporting a shift from weight-c...

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium

Abstract Background Clinical genetic evaluation for patients with dilated cardiomyopathy (DCM) is minimally implemented and models of care are not defined. To understand current genetics care for DCM, a systematic needs assessment was conducted. Methods Principal Investigators (P...

Sex-modulated associations between cytomegalovirus cell-associated DNA and cognition in people with HIV on ART

Background: People with HIV (PWH) remain at risk for cognitive impairment, despite effective antiretroviral therapy (ART), a phenomenon linked to chronic immune activation and inflammation. Cytomegalovirus (CMV) has been implicated in HIV-associated neurocognitive impairment, but...

Autologous hematopoietic stem cell transplantation stabilizes retinal atrophy in multiple sclerosis

Abstract Autologous hematopoietic stem cell transplantation (aHSCT) is an effective treatment for aggressive multiple sclerosis refractory to disease-modifying therapies. Yet, its impact on neurodegeneration remains underexplored, and few predictive biomarkers for clinical outcom...

The roles of symmetric and asymmetric parental histone recycling in cell fate, development, and disease

Replication of the epigenome occurs concurrently with DNA replication. A major component of epigenetic memory is contained in histones, and this memory is preserved via recycling of parental histones onto the leading and lagging strands of the replication fork. The histones of on...

The impoverishing effect of tobacco expenditures

Tobacco consumption is a major source of health and financial burden, yet evidence on its association with household poverty remains limited. This study examines how tobacco-related expenditures are associated with both the incidence and depth of poverty in Albania. Using nationa...

The Impact of Setting Characteristics on Community Health Worker Roles and COVID-19 Activities: An Examination of the Community Health Workers for COVID Response and Resilient Communities Program.

. 2026;116(S4):S295-S304. https://doi.org/10.2105/AJPH.2026.308660).

Best Practices for Integrating Community Health Workers Into Care Teams and Organizations: Lessons From the Front Line.

. 2026;116(S4):S365-S373. https://doi.org/10.2105/AJPH.2026.308685).

Bioprinted core-shell living material platform for spatially controlled encapsulation of Bacillus subtilis and sustained metabolite exchange

Antimicrobial resistance (AMR) represents an escalating global health crisis, demanding alternative strategies to reduce resistant pathogen burden across environments. Microbe-based biocontrol is promising, yet effectively deploying it in practical settings remains challenging. I...

Frameworks to identify research gaps, frame research needs, and derive research priorities from evidence syntheses:a scoping review

Objectives To identify and describe frameworks for systematically identifying research gaps from evidence syntheses, framing research needs, and establishing priorities, with emphasis on their use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) certai...

Validation of AACN’s Healthy Work Environment Assessment Tool–Team

Background In 2024, the American Association of Critical-Care Nurses (AACN) updated the Healthy Work Environment Assessment Tool (HWEAT), renamed HWEAT-Team. Objective Validating HWEAT-Team for interprofessional use. Methods This was a multisite, descriptive, nonexperimental corr...

Visual motion does not bias gravity-referenced vestibular coding in the primate cerebellar nodulus and uvula

Visual motion is known to influence perceptions of tilt, verticality, and translation, suggesting that optic flow is combined with vestibular cues to estimate orientation relative to gravity. The cerebellar nodulus and ventral uvula (NU) are a prime candidate to perform this comp...

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

ABSTRACT Targeting nanoparticles to cancer cells in vivo remains a challenge for cancer imaging. We assessed nanoparticle distribution after injecting iron oxide nanoparticles conjugated with either a monoclonal anti‐HER2 (human epidermal growth factor 2), or a non‐specific IgG a...

Rhinosinusitis in Adults Receiving Tumor Necrosis Factor Alpha Inhibitors and Anti‐CD20 Therapy: A Scoping Review

ABSTRACT Introduction Immunomodulatory therapies, including tumor necrosis factor alpha (TNF‐α) inhibitors and anti‐CD20 agents, are often used for autoimmune, inflammatory, and neoplastic disorders. While infection risk is well recognized, their association with rhinosinusitis r...

Genetic determinants that permit growth without the core septin Cdc12 in Cryptococcus neoformans

Septins are conserved cytoskeletal GTPases that regulate morphogenesis, cytokinesis, and cell-surface organization in fungi. In most model and pathogenic yeasts, including Saccharomyces cerevisiae and Candida albicans, core septin subunits such as Cdc3 and Cdc12 are essential and...

Reducing Within-Classroom Segregation and the Overuse of Paraeducators

Paraeducators are frequently assigned to work with disabled students as a means of providing access to the general education classroom. However, the provision of a paraeducator does not guarantee equitable access to classroom-based learning opportunities, authentic peer interacti...