Johns Hopkins University

An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy

BACKGROUND: Evidence of the diverse genetic architecture of dilated cardiomyopathy (DCM) continues to emerge and requires reassessment of the clinical relevance of implicated disease genes. Building on the 2019-2020 Clinical Genome Resource evaluation, the DCM gene curation exper...

Flourishing Childhood Frameworks: A Scoping Review

OBJECTIVES: Experiences in early life impact childhood, lifelong flourishing, and overall well-being. Yet a framework to guide promoting and measuring flourishing in early childhood has not emerged. The objective of this study was to identify frameworks and measures related to pr...

The Modern Urology Pipeline: Career Trajectories of Recent Residency Graduates

INTRODUCTION: Urology residency graduates face a pivotal transition when deciding on fellowship training and eventual practice setting. While traditionally a fellowship was a gateway to academia, recent trends reveal increasing pursuit due to job market concerns and perceived gap...

Hospital-Based Severe Maternal Morbidity Surveillance and Review

Background: Learning from promising maternal health interventions is limited by the lack of standardized outcome measures needed for their evaluation. We describe the development and utilization of Maryland’s severe maternal morbidity (SMM) surveillance by the Maryland Maternal H...

Associations Between Spatiotemporal Gait Parameters and Metabolic Outcomes in Younger and Functionally Limited Older Adults

Efficient walking depends on the interaction between both gait mechanisms and energy demand; however, this relationship may differ across age and functional groups. This study examines this association in younger and older adults. Sixty-four participants were divided into two gro...

Artifact Correction of Clinical Diffusion Weighted Imaging in Acute Ischemic Stroke

ABSTRACT Background Susceptibility‐induced geometric distortions and non‐physiologic hyperintensities confound acute ischemic stroke diagnosis on diffusion weighted imaging (DWI). Reverse phase‐encoded imaging needed for artifact correction is rarely acquired acutely. Structural...

Reframing Antimicrobial Stewardship as Systems Governance: Aligning Regulation, Diagnostics, Antibiotic Use Measurement, and Surveillance to Address Antimicrobial Resistance

Antimicrobial stewardship (AMS) is often framed as a set of prescribing-focused interventions aimed at optimizing antibiotic selection, dose, route of administration, and duration. In practice, AMS also functions as a systems discipline. Embedded within governance and regulatory...

Pharmacy Utilization Patterns and Polypharmacy as Predictors of High-Cost Workers’ Compensation Claims: An Updated Cohort Study of Occupational Ankle Sprains

Objective: Evaluate pharmacy utilization patterns as independent predictors of high-cost workers’ compensation claims (≥$50,000) for occupational ankle sprains. Methods: Pharmacy Benefit Management data were integrated into a 9-year cohort of 18,991 claims. Logistic regression mo...

Elastic modulus of recycled aggregate concrete: a multiscale-multiphase modeling approach

Abstract Concrete is a multiscale, multiphase composite material whose elastic properties are challenging to predict, particularly when recycled aggregates are used. The inclusion of recycled aggregates introduces greater heterogeneity due to residual mortar, microcracks, and var...

Perceptions of and Barriers to Colorectal Cancer Screening Uptake in Underserved Baltimore and Eastern Shore Populations

Colorectal cancer (CRC) remains a leading cause of preventable cancer mortality, with persistent screening disparities in underserved communities. This qualitative study aimed to identify community-specific barriers to CRC screening among two distinct Maryland populations to info...

A cluster-randomized controlled trial of a family-based psychosocial intervention to prevent childhood obesity from preschool ages: the PRESAFALIN study protocol

Abstract Background: Childhood obesity is a major global concern, and Spain's high obesity rates highlight the urgent need for effective and innovative interventions in early age. The PRESAFALIN study aims to promote parental competence, self-efficacy, and resilience to improve c...

Firearm Thefts from Vehicles in the United States: Results from a National Survey of Firearm Owners

Abstract This study examines the prevalence, characteristics, and behavioral responses associated with firearm thefts from vehicles in the United States. Data are from a national survey of firearm owners conducted by YouGov in February–March 2026 ( n = 1,976). Overall, 2.7% of re...

Best Case/Worst Case: A Multisite Randomized Trial of Scenario Planning for Patients With Late‐Stage Kidney Disease

BACKGROUND: Best Case/Worst Case (BC/WC) is a communication tool to support nephrologists and older adults with advanced chronic kidney disease with decisions about dialysis. We compared the effectiveness of training nephrologists to use BC/WC versus usual care on receipt of pall...

Development of a Computational Histology Artificial Intelligence-Powered Prognostic Biomarker in Colorectal Cancer in The Cancer Genome Atlas

Background: Risk stratification in colorectal cancer (CRC) plays an important role in treatment decision-making. As such, prognostic biomarkers that can augment risk stratification have clinical value. Quantitative histologic features from routine hematoxylin and eosin (H&E)-stai...

Satellite-based assessment of hydrologic synchronization across Western U.S. basins: Implications for water security

Study Region This study examines the Western United States including five HUC2 watersheds (Upper Colorado, Lower Colorado, Great Basin, California, Pacific Northwest) and 44 HUC4 sub-basins. This region supports over 60 million people and extensive agriculture with water stress f...

Procedure-related uptake on CXCR4 PET/CT: a frequent pitfall independent of time and anatomical site

Abstract Introduction As a pan-tumor tracer, chemokine receptor 4 (CXCR4)-directed [ 68 Ga]Ga-PentixaFor is frequently utilized in patients with hematological malignancies. We aimed to evaluate the impact of recent surgical and interventional procedures on uptake. Methods Patient...

Wind energy in Australia: challenges and opportunities on the path to decarbonisation

Despite its status as an advanced economy, Australia grapples with a paradox: an economic reliance on fossil fuel and raw material exports that impedes its commitment to curtailing global climate change. This paper underscores the potential of Australia’s wind resources, comparab...

Surface Thermal State, Antecedent Hydroclimate, and Post-Fire Vegetation–Water Response in the Zambezi River Basin: A Multi-Source Environmental Time-Series Analysis

Wildfire in African savannas reflects coupled surface thermal, hydroclimatic, vegetation, and disturbance processes, but basin-scale time-series analyses can overstate mechanisms when temporal dependence and spatial heterogeneity are ignored. We assembled a monthly 2003–2024 mult...

Nuclear Localization Signals Enable the Cellular Delivery of an Anti-CRISPR Protein to Control Genome Editing

ABSTRACT Precise regulation of Cas9 activity is essential to minimize off-target effects, mosaicism, chromosomal alterations, immunogenicity, and genotoxicity in genome editing. Although type II anti-CRISPR proteins (Acrs) can inhibit and regulate Cas9, their size and anionic cha...

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...