Institution
Johns Hopkins Medicine
Recent research
- BiologyOpen access
Impact of data quality on deep learning prediction of spatial transcriptomics from histology images
Abstract Background Spatial transcriptomic technologies enable high-throughput quantification of gene expression at specific locations across tissue sections, facilitating insights into the spatial organization of biological processes. However, high costs associated with these te...
- Health & MedicineOpen access
Adapting in-cell ELISA to investigate the localization of hepatitis C virus envelope glycoproteins
The development of hepatitis C virus (HCV) vaccines remains challenging due to extensive viral genetic diversity and the complex biology of the envelope glycoproteins E1 and E2, which are major targets of broadly neutralizing antibodies and are associated with spontaneous viral c...
- Health & MedicineOpen access
Background Lumbar facet-mediated pain is a common contributor to axial low back pain and may occur after traumatic or mechanical injury, even when advanced imaging demonstrates only mild degenerative or nonspecific findings. Standard interventional treatment pathways often includ...
- Health & Medicine
Pregnancy profoundly alters drug disposition through dynamic physiologic adaptations affecting absorption, distribution, metabolism, and excretion. Although pharmacogenomics has transformed precision therapeutics across multiple medical specialties, its application during pregnan...
- Society & Economics
Transplant Infectious Diseases Work Standards—Results From a Mid‐Atlantic Regional Survey
BACKGROUND: As transplantation and cellular therapy expand, so must the transplant infectious diseases (TID) workforce; yet little is known about regional or national TID work standards for the existing workforce. This survey of TID clinicians in the mid-Atlantic region seeks to...
- Health & Medicine
Comprehensive Analysis of US Health Care Spending on Injuries
BACKGROUND: Traumatic injury affects every age group, payer, and care setting in the United States, yet how injury-related spending distributes across these dimensions has not been comprehensively quantified. OBJECTIVE: To estimate US health care spending on injuries in 2022 by m...
- Health & MedicineOpen access
Physician Perceptions of Particulate Versus Non-Particulate Steroids in Epidural Steroid Injections
Background Epidural steroid injections (ESIs) are widely used for the treatment of chronic spinal pain, particularly in cervical and lumbar radiculopathy. Corticosteroids used in ESIs are broadly classified as particulate or non-particulate formulations, each with distinct safety...
- Health & Medicine
Agitation in dementia: Evidence-based consensus recommendations
Agitation is among the most disabling behavioral and psychological symptoms of dementia, contributing substantially to caregiver burden, institutionalization, and healthcare utilization. Considering the modest efficacy and significant adverse effects associated with psychotropic...
- BiologyOpen access
Distributed burst firing mediates optimized cortical encoding of natural self-motion
Accurate perception of self-motion requires that vestibular input be transformed into neural representations suitable for integrating multisensory cues to guide action. Here, we demonstrate that vestibular cortical neurons represent the self-motion stimuli encountered during ever...
- Health & MedicineOpen access
Abstract Background Diabetes is unique due to its cross-cutting nature, impacting multiple organ systems and increasing the risk for other communicable and non-communicable diseases if not managed properly. Managing diabetes involves frequent blood glucose measurement, medication...
- Health & MedicineOpen access
Reproducibility of Volumetric Analysis using Ultra-Low-Field Portable Magnetic Resonance Imaging
Brain volume change over time is an important imaging-based biomarker of disease. However, traditional MR scanners are associated with high direct and indirect costs both up front and over time, rendering them inaccessible to many around the world. Recently, ultra-low-field (64 m...
- Health & MedicineOpen access
Abstract Renal cell carcinoma risk is partly shaped by germline genetic variants that often reside in regulatory regions. However, the transcription factors (TFs) and downstream proteins via which they shape RCC susceptibility remain incompletely characterized. Here we show that...
- Materials & EnergyOpen access
Background/Objectives: Glioblastoma (GBM) remains one of the most aggressive primary brain malignancies, with limited therapeutic progress over the past two decades. Systemic administration of temozolomide (TMZ) is a pillar of clinical management but is constrained by poor brain...
- Health & MedicineOpen access
Abstract Introduction Pregnant people with congenital heart disease (CHD) are a growing patient population in obstetrics, yet evidence on the risk for severe maternal morbidity (SMM) has largely been limited to studies that lack specificity for CHD. We conducted this study to dem...
- Health & MedicineOpen access
Artificial intelligence-powered lifestyle interventions may expand access to behavioral change support, but patient experience remains critical to real-world uptake and effectiveness. In a phase 3 randomized clinical trial of adults with prediabetes and overweight or obesity ( N...
- Health & MedicineOpen access
PURPOSE: This prospective study is designed to test the validity of a multiple-choice question (MCQ) test in assessing theoretical knowledge of ultrasound-guided fine-needle aspiration biosy and core-needle biopsy of the head and neck. METHODS: Seven international experts reached...
- Health & Medicine
BACKGROUND: The demand for minimally invasive diagnostic techniques for peripheral pulmonary lesions (PPL) is rising. Augmented fluoroscopy (AF) provides real-time guidance by overlaying CT-derived virtual targets onto fluoroscopic images, yet its diagnostic value remains poorly...
- Health & MedicineOpen access
BACKGROUND: Chronic subdural hematoma is a complex but commonly treated neurosurgical condition, particularly affecting the elderly. Traditional treatment involves open surgeries, but middle meningeal artery embolization (MMAE) has emerged as an effective, minimally invasive adju...
- Health & MedicineOpen access
Ruling In and Ruling Out Sepsis Using Likelihood Ratios of a Host Response Assay
Overview: SeptiCyte RAPID is an FDA-cleared gene expression test that quantifies host immune response to aid in the diagnosis of sepsis. The test yields a score (the SeptiScore) ranging from 0–15, distributed across four bands (1–4) based on increased likelihood of sepsis. Each b...
- BiologyOpen access
Primer on Video-oculography and Video Head Impulse Testing for Neurologists
Abstract Purpose of Review Eye Movement and Vestibular findings can be manifestations of a wide range of neurologic diseases including and beyond those associated with peripheral vestibular dysfunction. Video-oculography (VOG) and video head impulse testing (vHIT) are accessible,...