Institution
Johns Hopkins Medicine
Recent research
- Health & MedicineOpen access
Physician Perceptions of Particulate Versus Non-Particulate Steroids in Epidural Steroid Injections
Background Epidural steroid injections (ESIs) are widely used for the treatment of chronic spinal pain, particularly in cervical and lumbar radiculopathy. Corticosteroids used in ESIs are broadly classified as particulate or non-particulate formulations, each with distinct safety...
- Health & MedicineOpen access
Abstract Background Diabetes is unique due to its cross-cutting nature, impacting multiple organ systems and increasing the risk for other communicable and non-communicable diseases if not managed properly. Managing diabetes involves frequent blood glucose measurement, medication...
- Health & Medicine
Agitation in dementia: Evidence-based consensus recommendations
Agitation is among the most disabling behavioral and psychological symptoms of dementia, contributing substantially to caregiver burden, institutionalization, and healthcare utilization. Considering the modest efficacy and significant adverse effects associated with psychotropic...
- BiologyOpen access
Distributed burst firing mediates optimized cortical encoding of natural self-motion
Accurate perception of self-motion requires that vestibular input be transformed into neural representations suitable for integrating multisensory cues to guide action. Here, we demonstrate that vestibular cortical neurons represent the self-motion stimuli encountered during ever...
- Materials & EnergyOpen access
Background/Objectives: Glioblastoma (GBM) remains one of the most aggressive primary brain malignancies, with limited therapeutic progress over the past two decades. Systemic administration of temozolomide (TMZ) is a pillar of clinical management but is constrained by poor brain...
- Health & MedicineOpen access
Abstract Renal cell carcinoma risk is partly shaped by germline genetic variants that often reside in regulatory regions. However, the transcription factors (TFs) and downstream proteins via which they shape RCC susceptibility remain incompletely characterized. Here we show that...
- Health & MedicineOpen access
Reproducibility of Volumetric Analysis using Ultra-Low-Field Portable Magnetic Resonance Imaging
Brain volume change over time is an important imaging-based biomarker of disease. However, traditional MR scanners are associated with high direct and indirect costs both up front and over time, rendering them inaccessible to many around the world. Recently, ultra-low-field (64 m...
- Health & MedicineOpen access
Abstract Introduction Pregnant people with congenital heart disease (CHD) are a growing patient population in obstetrics, yet evidence on the risk for severe maternal morbidity (SMM) has largely been limited to studies that lack specificity for CHD. We conducted this study to dem...
- Health & MedicineOpen access
BACKGROUND: Chronic subdural hematoma is a complex but commonly treated neurosurgical condition, particularly affecting the elderly. Traditional treatment involves open surgeries, but middle meningeal artery embolization (MMAE) has emerged as an effective, minimally invasive adju...
- Health & MedicineOpen access
Artificial intelligence-powered lifestyle interventions may expand access to behavioral change support, but patient experience remains critical to real-world uptake and effectiveness. In a phase 3 randomized clinical trial of adults with prediabetes and overweight or obesity ( N...
- Health & MedicineOpen access
Ruling In and Ruling Out Sepsis Using Likelihood Ratios of a Host Response Assay
Overview: SeptiCyte RAPID is an FDA-cleared gene expression test that quantifies host immune response to aid in the diagnosis of sepsis. The test yields a score (the SeptiScore) ranging from 0–15, distributed across four bands (1–4) based on increased likelihood of sepsis. Each b...
- Health & Medicine
BACKGROUND: The demand for minimally invasive diagnostic techniques for peripheral pulmonary lesions (PPL) is rising. Augmented fluoroscopy (AF) provides real-time guidance by overlaying CT-derived virtual targets onto fluoroscopic images, yet its diagnostic value remains poorly...
- Health & MedicineOpen access
PURPOSE: This prospective study is designed to test the validity of a multiple-choice question (MCQ) test in assessing theoretical knowledge of ultrasound-guided fine-needle aspiration biosy and core-needle biopsy of the head and neck. METHODS: Seven international experts reached...
- BiologyOpen access
Primer on Video-oculography and Video Head Impulse Testing for Neurologists
Abstract Purpose of Review Eye Movement and Vestibular findings can be manifestations of a wide range of neurologic diseases including and beyond those associated with peripheral vestibular dysfunction. Video-oculography (VOG) and video head impulse testing (vHIT) are accessible,...
- Biology
Schizophrenia Beyond Genome-Wide Association Studies: It’s About Time
The discovery of potentially many hundreds of risk genes for schizophrenia does not resolve the mystery of the illness at the level of an individual. The diversity of implicated gene functions has encouraged speculation that there are convergent biological pathways that mediate r...
- Health & MedicineOpen access
Adipose Tissue Browning in MASLD and Its Molecular Mechanisms and Metabolic Crosstalk
PURPOSE OF REVIEW: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly prevalent complication of obesity and metabolic dysregulation, with limited therapies targeting upstream drivers of disease. Adipose tissue has emerged as a central regulator of...
- Health & MedicineOpen access
BACKGROUND: To identify independent risk factors and predictors for botulinum toxin type A (BTA) reinjection within 6 months in acute acquired concomitant esotropia (AACE) patients, providing a scientific foundation for risk-stratified clinical management. METHODS: In this case-c...
- BiologyOpen access
Protocol for optogenetic stimulation of cells under physical confinement
Optogenetic approaches enable spatiotemporal control of signaling proteins, yet their integration with microfluidic assays to study confined cell migration remains challenging. Herein, we present a protocol for the optogenetic activation of PI3K/Akt signaling in confined cells. W...