Johns Hopkins Medicine

Significance of perinatal trauma screening and care coordination to improve infant health outcomes

This commentary addresses the need for trauma-informed screening and coordinated mental health care across obstetric (OB) and neonatal intensive care unit (NICU) settings. Perinatal post-traumatic stress disorder (PTSD) and related mental health conditions are common yet under-re...

Angiopoietin-Like 4 Induces Upregulation of VEGF and sVCAM1 Through JNK/c-Jun and JAK2/STAT5 Signaling Pathways

Purpose: Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine regulating angiogenesis, vascular permeability, and inflammation that is elevated, along with vascular endothelial growth factor (VEGF), in multiple ocular neovascular disorders, including ischemic retin...

Optical Diffraction Tomography and Interpretable Machine Learning Reveal Biophysical Signatures of Gametocyte-Stage Malaria in Red Blood Cells

Abstract Accurate, stage-specific diagnosis of Plasmodium falciparum infection is critical for clinical management and transmission control of malaria. Current diagnostic tools, including Giemsa-stained microscopy and rapid diagnostic tests (RDTs), are constrained by their relian...

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face...

Anterior Cervical Approaches for 2-Level Radiculopathy

Study Design: Anonymous, survey-based study. Objective: The primary objective of this study is to understand and assess the factors influencing the choice of cervical fusion, disc arthroplasty, and hybrid procedures for radiculopathy in the setting of 2-level cervical degenerativ...

Determinants of Symptom Burden in Non-Dialysis-Dependent Chronic Kidney Disease: A Cross-Sectional Cohort Study

Understanding symptoms experienced by people with non-dialysis-dependent chronic kidney disease (NDD-CKD) may improve person-centered outcomes. We characterized symptom burden in individuals with NDD-CKD by clinical and sociodemographic characteristics. We conducted a cross-secti...

Perseus: Lineage-Aware Refinement of Kraken2 Taxonomic Classification for Long Read Metagenomes

MOTIVATION: Long-read metagenomic sequencing improves assembly contiguity and enables genome-resolved analysis of complex microbial communities, but accurate taxonomic classification of long reads and assembled contigs remains challenging. Highly scalable k-mer-based classifiers...

Nontraumatic Osteonecrosis of the Femoral Head: An Update.

➢ Nontraumatic osteonecrosis of the femoral head should be suspected in patients who are <50 years of age who have persistent hip pain despite normal radiographs. ➢ Bilateral involvement is common; magnetic resonance imaging (MRI) of the contralateral hip is recommended. ➢ MRI is...

Landscape of approaches for streamlining pre-analytical and early analytical variables for solid tumor next-generation sequencing: A Genomics Organization for Academic Laboratories consortium report

The scope of pre-analytical and early analytical methods used in clinical molecular laboratories can have vast effects on the quality and turnaround time for solid tumor next-generation sequencing assays. To learn more about various approaches, a survey of 24 academic laboratorie...

Age-Friendly Health Systems in Hospital at Home: An Integrated Healthcare System Cross-Sectional Survey

Background Age-Friendly Health Systems (AFHS) is an evidenced-based initiative structured on the 4Ms framework (What Matters, Medications, Mentation, and Mobility) to improve care for older adult patients and has been implemented across the United States in various care settings....

Global Variation in Fusion Assessment Practices Following Anterior Cervical Discectomy and Fusion

Study DesignCross-sectional survey.ObjectivesTo characterize global variation in imaging modalities, fusion criteria, and decision-making practices for assessing fusion following anterior cervical discectomy and fusion (ACDF).MethodsA modified 30-item survey using Delphi-informed...

This Is My Story (TIMS), a Five-Year Thematic Analysis of Patient Narratives from a Novel Intervention in an Academic Hospital

Background/Objective: This is My Story (TIMS) is a patient-centered, interview-based audio narrative program that provides a humanistic intervention to help the medical team understand more information about a patient’s story that is not routinely captured in their medical chart....

New Annular, Indurated Plaques During Mogamulizumab Therapy in Cutaneous T‐Cell Lymphoma: A Clinicopathologic Pitfall

ABSTRACT New annular, indurated plaques arising during mogamulizumab therapy for cutaneous T‐cell lymphoma (CTCL) present a diagnostic challenge, as they may raise concern for treatment‐related eruption or disease progression. We report two patients with darker skin types who dev...

Immune cell dynamics during compensatory renal hypertrophy after unilateral nephrectomy

The mechanisms underlying compensatory renal hypertrophy (CRH) in living kidney donors after unilateral nephrectomy (UNx) remain complex and underexplored. We examined immune cells involved in CRH after UNx in mice. Following UNx of the left kidney in WT mice, GFR measurements, f...

The Transition of Youth With Diabetes From Pediatric to Adult Diabetes Care Services: A Consensus Report of the Joint Working Group of the International Society for Pediatric and Adolescent Diabetes (ISPAD), the European Association for the Study of Diabetes (EASD), and the American Diabetes Association (ADA)

Young adulthood is a period of significant and unique physiological, psychological, sexual, and social upheaval. Related challenges can have an impact on effective diabetes self-management, with high rates of unplanned health care use recorded for many, and consequent increases i...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Hybrid Respiratory Dialysis for Ultra-Low Blood-Flow Extracorporeal CO2 Removal

Extracorporeal carbon dioxide removal (ECCO 2 R) has emerged as a promising therapeutic avenue to address the challenges of CO 2 accumulation during chronic obstructive pulmonary disease (COPD) exacerbations. Current COPD exacerbation interventions rely on invasive mechanical ven...

Nascent chain folding feeds back on mRNA stability through the ribosome: Consequences for therapeutic mRNA design

In our recently published study in Molecular Cell,1 we describe a surveillance mechanism in which misfolding of the nascent chain slows the elongating ribosome and triggers co-translational decay of the mRNA encoding it (Figure 1). We propose that the ribosome-associated chaperon...

Biocompatible Microscale DNA Hydrogels with Programmable Swelling and Sequence-Specific Dissolution

Stimulus-responsive DNA hydrogels with swelling capabilities are a promising class of materials for biomedical applications such as drug delivery and biosensing. However, translation of these systems to microscale applications requires fabrication methods that are both biocompati...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...