Jinan University

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

ABSTRACT Hypertrophic scar (HS) is a recurrent and inflammatory dermal fibrotic disorder, characterized by abnormal fibroblast proliferation and excessive extracellular matrix (ECM) deposition. Affecting over 310 million patients worldwide, while effective strategies to halt prog...

In Situ detection of protein-phosphoinositide signalosome in tissues by immunohistochemistry-coupled proximity ligation assay

Abstract Phosphoinositides (PIPs) are central lipid signaling molecules, with PtdIns(3,4,5)P 3 acting as a key regulator of the PI3K-AKT pathway and a major driver of tumorigenesis. Together with p53 mutations or loss, this pathway represents one of the most frequently dysregulat...

Surrogate-assisted boundary-oriented multi-objective optimization of semi-rigid steel frame-brace-damper systems

Brace-damper co-design can improve the seismic performance of steel frames, but current optimization practice is limited by three issues: semi-rigid connection flexibility is often neglected; conventional Pareto searches may represent the attainable performance envelope unevenly;...

Prussian blue regulates ion dynamics in perovskite solar cells

Perovskite photovoltaics are limited by structural instabilities initiated during crystallization and amplified under operation. We report that a lattice-matched Prussian blue scaffold directs heterogeneous nucleation to produce highly oriented, strain-relaxed films. Its redox-ac...

Copper Peroxide-Loaded Dual-Responsive Hydrogel for Enhanced Diabetic Wound Healing Through Oxygen Release and Promotion of Angiogenesis

Diabetic foot ulcers (DFUs) present a major clinical challenge because of persistent hyperglycemia, hypoxia, impaired angiogenesis, and chronic inflammation. Conventional dressings have limited capacity to modulate these pathological processes. Here, we report a glucose/pH dual-r...

Large language models for pneumonia detection in radiology reports via text analysis

Pneumonia is a common infection in critically ill patients with poor outcomes, and its identification relies heavily on radiological evidence. Most MIMIC-based pneumonia studies rely on structured codes rather than radiological text, which may limit the precision of pneumonia-rel...

Too little time, too much to do: how time poverty undermines employees’ proactive service behavior

Purpose This paper aims to examine the relationship between time poverty and hotel employees’ proactive service behavior by identifying future self-continuity as a mediator and competitive climate as a moderator. Design/methodology/approach This research uses a multimethod design...

ALKBH5-Dependent m 6 A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration

BACKGROUND: N 6 -methyladenosine (m 6 A) modification has been linked to various types of physiological and pathological bioprocesses. However, the exact role of m 6 A mRNA methylation in cardiac aging is largely unknown. Here, we show that ALKBH5 (alpha-ketoglutarate-dependent d...

Remnant cholesterol predicts adverse clinical outcomes in patients with hypertension: a post hoc analysis of the ALLHAT

Background and purpose: Remnant cholesterol (RC) has been proposed to play a role in regulating the residual cardiovascular risk in individuals with atherosclerotic cardiovascular disease (ASCVD), yet the underlying mechanisms remain elusive. This study aimed to investigate the r...

Nuciferine Ameliorates Ovariectomy-Induced Bone Loss via TFEB-Mediated Autophagy-Lysosomal Pathway

Background: Postmenopausal osteoporosis is a common metabolic bone disease that leads to reduced bone formation and increased fracture risk. Nuciferine, an aporphine alkaloid from the lotus leaf, can regulate the TFEB-mediated autophagy-lysosomal pathway. This pathway is critical...

The Transformative Impact of Digital Innovation on Chinese Firms: Blessing or Burden?

This study explores the impact of digital transformation (DT) on firm performance, highlighting the ‘digital paradox’, where technological advancements yield mixed results. Using empirical analysis, we assess the relationship between DT, intangible assets, total factor productivi...

Parenting styles and fertility intention: Mediating effects of childbearing beliefs and psychological resilience

China's declining fertility rate is partly due to low fertility intention among childbearing population. To understand family influence on young people's fertility intention and its underlying mechanisms, this study examines how parenting styles (authoritarian vs. permissive) aff...

Disease Spectrum Characteristics and Differences Between Internal Medicine and Surgery in 1285 Elderly Inpatients with Dermatological Consultation

Objective to analyze the disease spectrum, demographic and departmental distribution characteristics of dermatological consultations among elderly inpatients, and compare the differences between internal medicine and surgical departments, so as to provide evidence for multidiscip...

Unlocking near-infrared-II chemiluminescence for biomedical imaging

By arising light from relaxation of excited-state reactants, chemiluminescence avoids autofluorescence interference, thereby allowing unique benefits for in vivo imaging. As an active branch of optical imaging, no-excitation luminescence in the second near-infrared (NIR-II, 1000–...

Clinical features of oxcarbazepine-associated cutaneous reactions in patients with bipolar disorder: a retrospective case series

Oxcarbazepine (OXC) is a second-generation antiepileptic drug that has been used in selected clinical settings as an alternative or adjunctive treatment option for bipolar disorder (BD). However, reports describing OXC-associated cutaneous reactions in patients with BD remain lim...

Species-dependent activities of the PINK1–parkin axis

In vitro studies have established that PTEN-induced putative kinase 1 (PINK1) and parkin are central regulators of mitophagy, and loss-of-function mutations in either gene can cause early-onset Parkinson's disease (PD). Although various animal models, including mice and pigs with...

Coordination‐Driven Pt(II)‐Ru(II) Heterometallacycles With Ultrastrong Cathodic Electrochemiluminescence and Guest‐Responsive Signal Amplification

ABSTRACT Coordination‐driven self‐assembly enables the integration of multiple functional elements within a single supramolecular architecture. By combining emissive chromophores, optimized electronic structures, and confined microenvironments, it provides an effective strategy f...

Maternal childhood maltreatment and adolescent internalizing problems: Intergenerational pathways via emotion regulation difficulties and offspring maltreatment

Background Research has established the intergenerational transmission of maternal childhood maltreatment to offspring internalizing problems. However, the potential indirect pathways underlying this intergenerational association remain under-explored, particularly regarding how...

MOF/polymer synergistic hybrid materials transforming the farm-to-table chain: chemical construction, performance regulation, and applications

Abstract Modern agriculture and food systems require materials combining controlled porosity, well-defined active sites, and scalable processability. MOF/polymer hybrids meet this need by integrating the film-forming ability, mechanical flexibility, and environmental protection o...

Short-term neonatal in-hospital associations following delivery room ETI versus PPV resuscitation: a multicenter retrospective cohort study

Abstract Background Endotracheal intubation (ETI) and positive pressure ventilation (PPV) are core neonatal resuscitation interventions. Baseline clinical imbalances confound gestational-age (GA)-specific associations between ETI and in-hospital adverse events. We evaluated GA-st...