Jinan University

Targeted Restoration of Mitophagy Reinvigorates Aged Hematopoietic Stem Cells

Aims: Aging-related functional decline in hematopoietic stem cells (HSCs) is closely associated with mitochondrial dysfunction and impaired mitophagy. This study aimed to investigate whether targeted restoration of mitophagy via the myeloid cell leukemia 1 (MCL-1)/light chain 3A...

Single-cell atlas of reproductive endocrine organs reveals transcriptomic responses to type 1 diabetes mellitus in nonhuman primates

Abstract Type 1 diabetes mellitus characterized by insulin deficiency and hyperglycemia is associated with female subfertility. However, how hyperglycemia affects the hypothalamic-pituitary-ovarian-uterine axis remains poorly understood. In this study, we performed single-cell tr...

Effects of customer participation on employee service innovation: the multi-level moderating role of ambidextrous leadership

Purpose Service innovation (SI) is critical for tourism enterprises to sustain competitive advantage. However, tourism firms are characterized by high levels of Customer participation (CP), which may both foster and hinder SI. Drawing on the Job Demands-Resources model, this rese...

Enhancing the Survivability of Flexibly Connected Modular Floating Structures Using a Novel Submerged Floating Mooring System

The survivability of modular floating structures operating in harsh marine environments is critical to their safe and reliable deployment. To enhance the survivability of a flexibly connected modular floating platform under extreme sea conditions, a novel submerged floating moori...

Nonmetallic plasmonic Al-doped W18O49 drives pure CO production from formic acid dehydration

As a vital industrial feedstock, carbon monoxide (CO) is widely employed in pharmaceutical, electronic and fine chemical synthesis, yet its efficient production in high purity remains challenging. Here we report a solar-driven route to high-purity CO from formic acid using a nonm...