Jinan University

AI-assisted discovery of an ABCA1/ABCG1 activator for restoring mitophagy and mitigating Alzheimer’s pathology

Abstract Defective mitophagy is a key pathological risk of Alzheimer’s disease (AD), yet available pharmacological agents capable of restoring mitophagy remain clinically limited, largely due to the lack of tools for drug screening and target identification. To address this, we i...

Influence of the Pore Structure on the Activity and Stability of Non-precious Metal Catalysts for Proton Exchange Membrane Fuel Cells

Abstract The activity/performance of non-precious metal catalysts for the oxygen reduction reaction (ORR) in fuel cells is critically dependent on the pore structure of the catalyst layer, but a systematic understanding of how micropores and mesopores affect activity and stabilit...

Boosting Aggregation-Induced Electro-Chemiluminescence in TPE-Based Macrocycles via Supramolecular Confinement: A Host−Guest Recognition Platform for 3-Nitrotyrosine Biosensing

Abstract Although aggregation-induced electrochemiluminescence (AIECL) holds significant promise for signal amplification, its practical advancement is impeded by the intrinsically low ECL efficiency of conventional AIEgens and the stochastic nature of aggregate formation. Herein...

Preconception maternal infection-related exposures and risk of congenital heart disease in offspring: evidence from a large population-based cohort in South China

Abstract Background Maternal infections during pregnancy have been associated with congenital heart disease (CHD) in offspring. However, the associations of preconception maternal infection-related exposures with offspring CHD risk remain unclear. This study aimed to evaluate the...

Comparison of visual outcomes following ray-tracing-guided femtosecond laser-assisted in situ keratomileusis with different optical zone sizes

To evaluate the impact of different optical zone (OZ) size on clinical outcomes following ray-tracing-guided femtosecond laser-assisted in situ keratomileusis (FS-LASIK). A total of 126 eyes of 63 patients were stratified by intended OZ size: 6.5- group (6.0 - 6.5 mm) and 6.5+ gr...

Relative height and vertical status in buildings

Abstract Motivated by research that associates higher positioning with well‐being, we expand the vertical price‐gradient literature by estimating the value of within‐ and between‐building “vertical status”: one's relative vertical position compared to others in the same building...

Beyond psychology and environment explanations: a linguistic microfoundation approach to entrepreneurs’ anxiety

We offer a novel theoretical account of why entrepreneurs experience anxiety and how entrepreneurs cope with anxiety. We integrate insights from linguistic theories into entrepreneurship literature to propose that entrepreneurs’ linguistic architecture—particularly the vocabulary...

The impact of perceived fairness on consumers’ willingness to pay for water quality improvements: evidence from China

Financing drinking water improvements in low tariff regimes requires price increases, yet affordability alone cannot ensure public acceptance. In a survey experiment with 1027 urban Chinese residents, perceived fairness is associated with 0.58–0.84 RMB/m3 higher WTP for cleaner r...

A unified and accurate approach to simulating monotonic and cyclic failure effects of metallic and concrete materials

Purpose A unified and accurate approach is established for the purpose of simulating monotonic and cyclic failure effects of metallic and concrete materials based on an all-through strength-degrading elastoplasticity model. This new model makes no reference to any usually postula...

Cognition, attitudes, and willingness toward biobank donation among the older adults: a cross-sectional survey of 1,143 participants in China

Abstract Background Biobanks are fundamental infrastructures for medical research, and their sustainable development depends on public participation and support. Older adults are at high risk of age-related diseases, making their biospecimens particularly valuable for scientific...

Single-Atom Modification Enables Reversal of Degradation Selectivity between NSD2 and GSPT1

Abstract Both NSD2 and GSPT1 represent compelling targets for anticancer drug discovery. Herein, we carried out single-atom modification of LLC0424, an NSD2 degrader with GSPT1 neosubstrate engagement, to yield two structurally analogous molecules with divergent modes of action:...

First Total Syntheses of Both C10 Epimers of Mycenolide A: Stereochemical Assignment and Reassessment of Its Reported Neuroprotective Activity

Abstract Mycenolide A, a marine-derived 5-substituted butenolide, possesses a remote C10 quaternary stereocenter whose absolute configuration was previously unassigned. Herein, we report the first stereodivergent total syntheses of both C10-epimers of mycenolide A in only nine st...

Intelligent Governance of Complex Social Systems: A Hybrid AI–System Dynamics Model for the Simulation and Projection of Sustainable Energy Transition

Amidst growing uncertainty regarding global sustainable development goals and the increasing complexity of social systems, accurately characterizing long-term transition processes driven by the interactions of multiple agents and factors remains a critical challenge. Using China’...

Methyl eugenol increases neural microcirculation to promote nerve repair by regulating endothelial cell and Schwann cell communication via Ptn/Sdc4

Neuromicrocirculatory disorders often accompany nerve injury. Improving neural microcirculation can promote the repair of injured nerves. Methyl eugenol is a major bioactive component of Asarum heterotropoides and has been reported to exert analgesic effects in chronic pain. This...

Advances and Challenges in mRNA Cancer Vaccines: Individualized Design and Delivery

Since the widespread use of mRNA-based COVID-19 vaccines, significant progress has also been made in mRNA cancer vaccines. Currently, mRNA cancer vaccines represent one of the most promising treatments for advanced tumors, with several candidates in clinical trials. Compared with...

Engineered mesenchymal stem cell-derived extracellular vesicles overexpressing miR-146a alleviate neuroinflammation in Alzheimer's disease.

Alzheimer’s disease is an inflammatory neurodegenerative disease for which no effective clinical treatment currently exists. We have previously reported that mesenchymal stem cell–derived extracellular vesicles delay retinal degeneration by exerting anti-inflammatory effects thou...

Toxicokinetics Reveal Structure-Related Differences in Developmental Toxicity among Typical Aromatic Disinfection Byproducts in Zebrafish Embryos

Abstract Aromatic disinfection byproducts (DBPs) are emerging contaminants generated during drinking water disinfection and exhibit higher cytotoxicity and genotoxicity than traditional aliphatic DBPs. However, in vivo toxicokinetic behavior of aromatic DBPs during sensitive deve...

Machine learning-enabled prediction and interpretation of spectroscopic properties in Nd and Y co-doped fluorite platform via local coordination engineering

The design of advanced laser materials demands precise control over the relationship between local structure and spectroscopic performance. However, conventional approaches struggle to quantitatively link complex coordination environments with spectral properties in rare-earth-do...

Phthalate Pollution and Its Induced Oxidative Stress in the Root–Soil Interface Altering Maize Root-Associated Microbiomes

Abstract Phthalate (PAE) residues adversely affect the root-associated microbiome and growth of plants. However, the pollution-driven alteration in root-associated microbiota and the potential effect factors remain elusive. Here, we systematically investigated the toxic impacts o...

Effects of plant roots on the erodibility of compacted soils can be explained by a biological indicator derived from Wilson’s model

Abstract Aim Compacted slopes demand herbaceous cover for erosion control. This study aims to develop improved understandings on how compacted soil properties––particle size and relative density––interact with grass roots to regulate soil erodibility to resist rill detachment. Me...