Jinan University

Single-fiber three-dimensional shape sensing via femtosecond laser inscribed orthogonal eccentric scatterers

Optical fiber sensors have emerged as a powerful platform for high-precision shape detection in soft robotics and minimally invasive medical devices. However, existing fiber-sensing architectures face a long-standing trade-off between device size and spatial resolution. This work...

Composite Hydrogel Loading Polysaccharides Derived from Coptis chinensis Franch. for Promoting Diabetic Wound Healing

Efficient treatment of diabetic wounds (DW) remains a major clinical challenge worldwide owing to vascular insufficiency, multiple bacterial infections, and overactivation of pro-inflammatory M1 macrophages caused by hyperglycemia. The development of novel pharmaceutical agents w...

Efficacy of anti-PD-1/PD-L1 plus chemotherapy in treatment-naïve advanced HER2-negative gastric adenocarcinoma among different PD-L1 intervals: an updated meta-analysis and reconstructed individual patient-level data analysis

Abstract Background Chemo-immunotherapy (CIT) has become the frontline therapy for advanced human epidermal growth factor receptor 2 (HER2)-negative gastric or gastro-esophageal junction adenocarcinoma (GEAC). However, emerging evidence suggests that clinical benefit is primarily...

Ultrafiltered Mulberry (Morus alba L.) Leaf Albumin-Type Protein Attenuates High-Fat Diet-Induced Obesity in Mice by Remodeling Gut Microbiota and Metabolic Homeostasis

Obesity is a chronic metabolic disorder closely associated with dyslipidemia, insulin resistance, low-grade inflammation, and gut microbiota dysbiosis. Mulberry leaves are rich in bioactive proteins, but whether mulberry leaf albumin-type protein can improve diet-induced obesity...

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, activated by cytosolic mitochondrial DNA (mtDNA), has been increasingly implicated in UC. Through p...

Intravenous Administration of Stromal Vascular Fraction Attenuates Early Busulfan-Induced Testicular Injury in Rats: An Alternative Cell-Based Approach for Spermatogenic Impairment

Stromal vascular fraction (SVF), an uncultured adipose-derived cell population, exerts regenerative effects primarily through paracrine mechanisms. While local intratesticular injection of SVF alleviates busulfan-induced testicular injury, the intravenous route remains unexplored...

Targeted Restoration of Mitophagy Reinvigorates Aged Hematopoietic Stem Cells

Aims: Aging-related functional decline in hematopoietic stem cells (HSCs) is closely associated with mitochondrial dysfunction and impaired mitophagy. This study aimed to investigate whether targeted restoration of mitophagy via the myeloid cell leukemia 1 (MCL-1)/light chain 3A...

Single-cell atlas of reproductive endocrine organs reveals transcriptomic responses to type 1 diabetes mellitus in nonhuman primates

Abstract Type 1 diabetes mellitus characterized by insulin deficiency and hyperglycemia is associated with female subfertility. However, how hyperglycemia affects the hypothalamic-pituitary-ovarian-uterine axis remains poorly understood. In this study, we performed single-cell tr...

Effects of customer participation on employee service innovation: the multi-level moderating role of ambidextrous leadership

Purpose Service innovation (SI) is critical for tourism enterprises to sustain competitive advantage. However, tourism firms are characterized by high levels of Customer participation (CP), which may both foster and hinder SI. Drawing on the Job Demands-Resources model, this rese...

Enhancing the Survivability of Flexibly Connected Modular Floating Structures Using a Novel Submerged Floating Mooring System

The survivability of modular floating structures operating in harsh marine environments is critical to their safe and reliable deployment. To enhance the survivability of a flexibly connected modular floating platform under extreme sea conditions, a novel submerged floating moori...

Nonmetallic plasmonic Al-doped W18O49 drives pure CO production from formic acid dehydration

As a vital industrial feedstock, carbon monoxide (CO) is widely employed in pharmaceutical, electronic and fine chemical synthesis, yet its efficient production in high purity remains challenging. Here we report a solar-driven route to high-purity CO from formic acid using a nonm...