Jinan University

Spatially Controlled Imaging of Proteases in Acidic Extracellular Milieu of Lesions Using DNA‐Peptide‐PNA Hybrid Probes

ABSTRACT In situ detection of proteases has been extensively exploited for diverse biomedical applications; however, spatially controlled amplified imaging of extracellular proteases at diseased sites remains a significant challenge. Here, we report the design of DNA‐peptide‐PNA...

Smart city policy and firm digitalization: evidence from MD&A disclosures

Purpose This study aims to examine whether smart city policies influence corporate digital transformation. Using China’s National Smart City Pilot Project as a quasi-natural experiment, we investigate if smart city designation affects firms’ digitalization levels as reflected in...

Stable High‐Rate Sodium Metal Batteries at Room and Low Temperature Enabled by Mixed Ion/Electron‐Conducting Interphase Engineering

Sodium metal batteries (SMBs) with high energy density showed great promise for various applications, but they are plagued by uneven and low‐reversibility sodium plating/stripping, particularly when fast‐charging capability at subzero temperatures is pursued. Here, we present a f...

Programmable RNA targeting with clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas7-11 in zebrafish embryos and mammalian cells

<title>Abstract</title> <bold>Background</bold> The CRISPR/Cas7-11 system is a recently characterized RNA editing tool that exhibits low toxicity, minimal off-target effects, and reduced collateral RNA cleavage compared with existing methods. Although zebrafish and human embryoni...

Crystalline Mate Assists Structural Elucidation and Offline LC‐SCXRD Analysis of Flavonoid Glycosides via Synergistic π–π Stacking and C–H···O Interactions

Single-crystal X-ray diffraction (SCXRD) is a key technique for the structural determination of organic molecules. However, natural flavonoid glycosides are difficult to crystallize due to their large volume, flexible glycosidic bonds, and limited solubility. Herein, a novel meth...

Reconfigurable multibeam engineering of Marangoni convection for programmable optofluidic steering

Optofluidic manipulation provides a powerful route for guiding micro- and nanoparticles, yet conventional light-induced flow systems often suffer from limited controllability, unstable flow patterns, and poor reconfigurability. Here, we demonstrate programmable optofluidic steeri...

Associations of early-life exposure to PM2.5 mass and its components with childhood anemia: A cross-sectional study in China, India, and Africa

Childhood anemia remains a major public health concern, but evidence regarding the associations of early-life exposure to PM 2.5 mass and its components with childhood anemia across regions remains limited. We conducted a cross-sectional study of 449,894 children under 5 years fr...

Uncertainty-inspired open-set model for identifying infantile fundus abnormalities

Accurate and safe identification of infantile fundus abnormalities is critical for large-scale screening, yet remains challenging because of heterogeneous disease presentations and overconfident predictions by conventional artificial intelligence (AI) models. In this study, we ai...

Role of Life’s Essential 8 in the association of night shift work with cardiovascular disease and mortality: a prospective cohort study of UK Biobank participants

Background: Night shift work is linked to higher risks of cardiovascular disease (CVD) and mortality, but mechanisms remain unclear. Lifestyle, captured by the American Heart Association's Life's Essential 8 (LE8), may act as a modifiable mediator. We aimed to examine the associa...

Identification of prognostic genes for hepatocellular carcinoma based on hepatocyte and ketone body metabolism using integrated bulk and single cell RNA sequencing

<title>Abstract</title> Background The precise role of ketone body (KB) metabolism and the underlying cellular mechanisms in hepatocellular carcinoma (HCC) remain unclear. This study aimed to identify and mechanistically explore KB metabolism-related prognostic genes in HCC. Meth...

Action chunking transformer-based imitation learning with dynamic programming optimization for low-cost robotic assembly tasks

Nowadays, many studies focus on using AI tools to improve the performance of manipulators in fields such as assembly. One popular approach is the Action Chunking Transformer (ACT), which enables robots to execute assembly tasks more efficiently. However, this method still faces c...

Artificial intelligence and liquidation: Reality, destiny and fantasy

Abstract Artificial intelligence (AI) is increasingly reshaping the administration of corporate liquidation. Beyond its established role in financial prediction and data analytics, AI is now assisting insolvency practitioners in identifying the onset of financial distress, managi...

Heart rate control by listening to light

The auditory-cardiac interplay enables sound perception to modulate cardiac rhythm and homeostasis. However, its underlying regulatory mechanism and therapeutic potential remain largely underexplored, due to fundamental limitations in acoustic stimulation precision. Here we prese...

Composite Hydrogel Loading Polysaccharides Derived from Coptis chinensis Franch. for Promoting Diabetic Wound Healing

Efficient treatment of diabetic wounds (DW) remains a major clinical challenge worldwide owing to vascular insufficiency, multiple bacterial infections, and overactivation of pro-inflammatory M1 macrophages caused by hyperglycemia. The development of novel pharmaceutical agents w...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

Single-fiber three-dimensional shape sensing via femtosecond laser inscribed orthogonal eccentric scatterers

Optical fiber sensors have emerged as a powerful platform for high-precision shape detection in soft robotics and minimally invasive medical devices. However, existing fiber-sensing architectures face a long-standing trade-off between device size and spatial resolution. This work...

Efficacy of anti-PD-1/PD-L1 plus chemotherapy in treatment-naïve advanced HER2-negative gastric adenocarcinoma among different PD-L1 intervals: an updated meta-analysis and reconstructed individual patient-level data analysis

Abstract Background Chemo-immunotherapy (CIT) has become the frontline therapy for advanced human epidermal growth factor receptor 2 (HER2)-negative gastric or gastro-esophageal junction adenocarcinoma (GEAC). However, emerging evidence suggests that clinical benefit is primarily...

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, activated by cytosolic mitochondrial DNA (mtDNA), has been increasingly implicated in UC. Through p...

Ultrafiltered Mulberry (Morus alba L.) Leaf Albumin-Type Protein Attenuates High-Fat Diet-Induced Obesity in Mice by Remodeling Gut Microbiota and Metabolic Homeostasis

Obesity is a chronic metabolic disorder closely associated with dyslipidemia, insulin resistance, low-grade inflammation, and gut microbiota dysbiosis. Mulberry leaves are rich in bioactive proteins, but whether mulberry leaf albumin-type protein can improve diet-induced obesity...

Intravenous Administration of Stromal Vascular Fraction Attenuates Early Busulfan-Induced Testicular Injury in Rats: An Alternative Cell-Based Approach for Spermatogenic Impairment

Stromal vascular fraction (SVF), an uncultured adipose-derived cell population, exerts regenerative effects primarily through paracrine mechanisms. While local intratesticular injection of SVF alleviates busulfan-induced testicular injury, the intravenous route remains unexplored...