Inserm

Methods for assessing the acquisition of pharmaceutical care skills among students and pharmacists: a scoping review

Abstract Introduction Competency-based education is central to preparing health professionals for complex, patient-centered practice. In clinical pharmacy, assessing medication-related care competencies remains challenging due to a lack of standardized frameworks adaptable to dig...

Pro-apoptotic polymers for neutrophil-induced inflammation modulation: from screening to therapeutic potential

Human polymorphonuclear neutrophils (PMNs) are pivotal in the initiation and resolution of inflammation, playing an essential role in maintaining tissue homeostasis and facilitating repair. This study investigates how polymers influence PMNs apoptosis, a favourable step for the r...

A cross-species atlas platform for comparative neuroscience in teleost fish

Abstract Uncovering general principles connecting neural circuits to behaviour requires comparative brain analyses across species. To advance these efforts, we developed a standardised workflow and a unified brain atlas platform for the quantitative comparison of neural structure...

Early systemic intervention for vitiligo: A prospective bicentric interventional study

BACKGROUND: Vitiligo is a complex autoimmune skin disease characterized by loss of melanocytes resulting in the appearance of white skin patches. Recent advances in treatment have improved patient outcomes, but the process of repigmentation is prolonged and often incomplete. OBJE...

Measuring children’s HRQoL via self-reports and parent proxy-reports in the French Enabee 2022 study: an evaluation of the psychometric properties of both versions of the French KINDL-R questionnaire

Child well-being policies require quality data that takes children’s perspectives into account, recorded through appropriate, accurate and reliable measurement instruments. This study evaluated the psychometric properties of two versions of the KINDL-R questionnaire used in the 2...

Occurrence and Genomic Characterization of Listeria monocytogenes ST121 in Animal-Derived Food Samples from Bejaïa, Algeria

Listeria monocytogenesis an important foodborne pathogen that can cause severe invasive disease in vulnerable populations. This study assessed the occurrence of L. monocytogenes in animal-derived foods collected in Bejaïa, Algeria, and characterized recovered isolates using whole...

Symptomatic primary aortic mural thrombus: Findings after 6 months of oral anticoagulation

Background: Primary aortic mural thrombus (PAMT) is defined by an aortic thrombus in the absence of underlying aortic disease. Management relies on anticoagulation, with or without surgery, but optimal treatment duration remains uncertain. We evaluated clinical and radiological o...

Are older adults in China living longer happy years? A cohort-based multistate analysis, 2002–2018

Abstract China’s rapid population ageing raises the question of whether added years of life are also happy years. Using data from the Chinese Longitudinal Healthy Longevity Survey (2002–2018), we applied a cohort-based multistate life table method to estimate partial-cohort happy...

Life-sustaining treatment preferences at end of life: a comparison between ICU and non-ICU hospital professionals

We compared personal end-of-life preferences for life-sustaining treatments (LST) between intensive care unit (ICU) caregivers and other hospital professionals. In a cross-sectional survey of 743 French hospital professionals (ICU caregivers, n = 195; non-ICU caregivers, n = 349;...

Assessing dengue knowledge, attitudes and preventive practices in France and Italy: A cross-sectional study using participatory surveillance cohorts

The dengue virus, transmitted by Aedes mosquitoes, causes an estimated 100–390 million infections annually worldwide. With no treatment available, mitigation and prevention involve reducing mosquito breeding and limiting feeding opportunities. Due to changing climate conditions,...

The elongation of Mest transcript into MestXL sustains, but does not initiate, the maternal allele bias of its convergent gene Copg2 during neurogenesis

Abstract Precise gene dosage control is critical for cellular identity and development, particularly for imprinted genes, where dosage imbalances are linked to neurodevelopmental disorders. The Mest/Copg2 imprinted locus exemplifies this fine-tuned regulation: while Mest is const...

Probiotics and Risk of Death, Necrotizing Enterocolitis, and Sepsis in Very Preterm Infants

Importance Probiotics are reported to benefit preterm infants, but population-based clinical evidence is limited. In 2020, the Swedish Neonatal Society issued a national recommendation to supplement very preterm infants (28 weeks 0 days’ to 31 weeks 6 days’ gestation) with probio...

An inertial‐based spiral device for separating rare tumor cells from liquid biopsies

Abstract Early detection of primary tumors and metastatic processes increases the success of anti‐tumor therapies and favors good prognoses. Within the current range of methods available to detect the presence of tumors, liquid biopsy is receiving particular attention as it is a...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Revisiting the role of lymphatics in Crohn's disease.

BACKGROUND: Early pathological observations consistently highlighted the involvement of the intestinal lymphatic system in Crohn's disease (CD), although this remains underappreciated in current conceptual models of disease pathogenesis. This narrative review synthesizes evidence...

Mechanical Thrombectomy Versus Medical Management for Large Ischemic Core Stroke Identified before Inter‐Hospital Transfer: A Post Hoc Analysis of the LASTE Trial

Objective This study assessed the efficacy of thrombectomy in acute ischemic stroke because of large‐vessel occlusion (AIS‐LVO) initially admitted to primary stroke centers (PSC) and subsequently transferred to a comprehensive stroke center (CSC), with a large ischemic core ident...

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoi...

Organoids and Spheroids for the Design and the Evaluation of Therapeutic Strategies

The design and the evaluation of effective therapeutic modalities have long relied on experimental models that only partially reproduce human physiology [...]

Toward More Predictable Musculoskeletal Embolization: A Translational Evaluation of Imipenem–Cilastatin Performance and Safety in a Porcine Model of Tendon Neovascularization

Background: There is a need to provide a translational evaluation of imipenem–cilastatin as an innovative musculoskeletal embolic agent by assessing its embolization efficacy, physicochemical behavior, and safety profile in a porcine model of intratendinous neovascularization. Ma...

The Chornobyl Dogs: Why Scientific Evaluation Must Accompany Population Management

Nearly four decades after the 1986 reactor explosion, several hundred semi-feral dogs persist within the Chornobyl Exclusion Zone. Genomic work has characterised their population structure and shown that radiation-induced mutation does not, on current evidence, drive the differen...