Inserm

Handwriting Isochrony in Autistic and Non-Autistic Children

Handwriting difficulties are frequently reported in autistic children and may interfere with academic performance. However, whether fundamental motor principles such as isochrony are preserved in autism remains largely unexplored. To address this question, fifty-five autistic and...

Determinants of screening participation of disadvantaged populations in France: a qualitative study

Background People from deprived backgrounds and people with disability have generally limited access to health screening. This study aimed to identify the factors influencing access to recommended screenings for these disadvantaged groups, to inform development of tailored screen...

Beyond counting errors: clinical pathway-specific preanalytical risk profiles in surgical pathology

To determine whether clinical referral pathways exhibit distinct preanalytical risk profiles that could complement conventional laboratory-wide quality assessment in surgical pathology. We conducted a retrospective observational study of prospectively recorded preanalytical non-c...

Environmental cues shape mucosal enteric glia networks independent of lamina propria innervation

Abstract Mucosal enteric glia are implicated in different aspects of gut function but the determinants of their occupancy of the lamina propria remain obscure. Analyzing mucosal enteric glia during intestinal inflammation and in mouse models differing for diet and gut microbiota,...

The impact of chemotherapy-induced menopause on quality of life 30 months following treatment among young women with non-metastatic breast cancer: results from the prospective multicentre MENOCOR clinical trial

Breast cancer is the most common cancer among women in France and worldwide, with about one quarter of cases occurring before 50 years old. These younger women often present more aggressive tumours, requiring intensive treatments. However, chemotherapy frequently causes ovarian t...

Cross-protection of wildtype and vaccine-derived chikungunya virus antibodies against chikungunya and Mayaro viruses in mice

Abstract The live-attenuated vaccine IXCHIQ against chikungunya virus (CHIKV) was approved in 2023, with its efficacy evaluated using human neutralizing antibody titers as surrogate effectiveness criterion. Previous in vivo studies assessed its efficacy at high CHIKV-specific ant...

Routing to the seizure in postoperative human glioma cortex: spatio-temporal uncoupling between slow and fast extracellular neuronal activities

Abstract Background Diffuse gliomas are frequently associated with epilepsy, particularly in low-grade variants. Seizures are key events to be considered in glioma management, including during surgery. Optimizing resection of epileptic areas may affect not only postoperative epil...

Optimizing Portal Venous Phase Acquisition Quality of Contrast-Enhanced CT in Oncology

Background: Portal venous phase (PVP) contrast-enhanced CT is a cornerstone for response assessment in early-phase oncology trials, yet contrast-enhancement phase timing remains insufficiently monitored across sites. We assessed PVP timing using a validated artificial intelligenc...

What a highly monitored chikungunya epidemic reveals about preparedness for Europe and beyond

The 2024–25 chikungunya epidemic in Reunion Island illustrates the challenge of translating early warning into timely public-health action during fast-moving arboviral outbreaks. Despite advanced surveillance, the epidemic accelerated rapidly and placed substantial pressure on pr...

Assessing a local vaccination initiative: Eight years of “Immuniser Lyon” in France

“Immuniser Lyon” (IL) is a French city-level initiative launched in 2015 to promote vaccination through coordinated, locally tailored actions. The objective of this study is to describe and compare temporal trends in vaccine coverage for HPV and influenza in the Rhône area versus...

Drug allergy de-labelling with a direct oral challenge in outpatient hospital visits

Abstract Although direct oral challenge has been adopted by numerous clinicians worldwide in the context of drug hypersensitivity, drug allergy de-labelling remains largely confined to inpatient or outpatient hospital-based care,mostly for penicillins. In this study, we aim to pe...

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Can machine learning be used to quantify blood loss based on hemodynamic data? Experimental study of controlled hemorrhagic shock in anesthetized piglets

Background Hemorrhagic compensatory physiological mechanisms may initially lead to an underestimation of the severity of a hemorrhage, for which quantification of blood lost volume is difficult. The objective of our study was to assess the suitability of machine learning (ML) to...

Assessing Behavioral and Environmental Facets of Obesity Unobtrusively Utilizing Digital Tools: Introducing the BETTER4U Indicators

ABSTRACT Understanding obesity involves evaluating numerous contributing factors. Collecting the necessary data for this can impose a significant burden on both research participants during clinical studies and real‐life deployments of digital tools aiding obesity management. The...

The petal identity gene PhDEF has a major binding and regulatory action in the epidermis

ABSTRACT In flowering plants, floral organ identity is specified by the combinatorial action of homeotic genes. While the role of these genes in the early specification of organ identity is well established, their late function throughout floral organ development and in specific...

Paraneoplastic podocytopathies with nephrotic syndrome in solid cancers with C-Maf Inducing Protein expression

Abstract Background The main features of minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) associated with solid cancer (paraneoplastic podocytopathy with nephrotic syndrome, PPNS) remain poorly described. Methods In this French retrospective study, we fo...

Revisiting Identification Thresholds of Specific Learning Disorders ( SLD ) in Gifted Children ( GC ). A Comparison of Three Groups: Twice‐Exceptional ( TE ) Children, GC Without SLD and Non‐ GC With SLD

ABSTRACT This study investigates assessment of Specific Learning Disorders (SLD) in Twice‐Exceptional (TE) children, gifted children (GC) who also present SLD, in oral and written language domains. Applying the standard threshold for identification (< 7th percentile) to GC often...

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Longitudinal Modeling of Cardiometabolic Dysfunction in Patients With Type 2 Diabetes Using Item Response Theory

ABSTRACT Cardiometabolic dysfunction in patients with type 2 diabetes (T2D) is reflected by multiple risk factors and cannot be fully characterized by any single biomarker. Item response theory (IRT) provides a framework for integrating observed risk factors into latent measures...

Gene-rich fungus gnat germline-restricted chromosomes are largely transcriptionally quiescent

Germline-restricted chromosomes (GRCs) constitute a unique class of chromosomes confined to germ cells. Arising in multiple evolutionarily distant lineages, GRCs have been identified in three insect families (non-biting midges, gall midges, and fungus gnats), each within the orde...