Inserm

Organoids and Spheroids for the Design and the Evaluation of Therapeutic Strategies

The design and the evaluation of effective therapeutic modalities have long relied on experimental models that only partially reproduce human physiology [...]

Atenolol or Bisoprolol after Myocardial Infarction without Recorded Heart Failure

BACKGROUND: Beta-blockers are a cornerstone of therapy following myocardial infarction. The effect of different β-blockers on the outcomes of patients without heart failure after myocardial infarction is not well-studied. METHODS: This observational cohort study used administrati...

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoi...

Mechanical Thrombectomy Versus Medical Management for Large Ischemic Core Stroke Identified before Inter‐Hospital Transfer: A Post Hoc Analysis of the LASTE Trial

Objective This study assessed the efficacy of thrombectomy in acute ischemic stroke because of large‐vessel occlusion (AIS‐LVO) initially admitted to primary stroke centers (PSC) and subsequently transferred to a comprehensive stroke center (CSC), with a large ischemic core ident...

A framework for outcome determination of nosocomial pneumonia treatment in ventilated critically ill patients

Abstract Background Treatment failure of hospital-acquired (HAP) and ventilator-associated pneumonia (VAP) is a common endpoint in clinical research, yet the absence of a reproducible definition hampers comparability across studies. We propose an operational framework for assessi...

Involving Patients in Pharmacoepidemiology Studies Conducted on Healthcare Administrative Database: Results of a Feasibility Study in France

BACKGROUND: Patient and public involvement in pharmacoepidemiology using healthcare administrative databases remains limited despite its potential to enhance research relevance and societal impact. We evaluated the feasibility and benefits of involving patients as research partne...

Unprecedented In Vivo MRI Resolution of Basal Ganglia at 11.7 T

This case report describes 11.7-T in vivo human brain magnetic resonance imaging (MRI) of the basal ganglia in 2 healthy volunteers.

Performance of pseudonymization methods applied to hospital documents in the context of health data warehouses

Introduction The development of health data warehouses (HDWs) in France raises concerns about personal data protection. Regulations require health research to use anonymized or pseudonymized data. This study evaluates a document pseudonymization tool developed by Assistance Publi...

Complement C3a receptor expression is associated with distinct immune microenvironmental profiles in clear cell renal cell carcinoma

The complement receptor C3aR has emerged as an important regulator of tumor–immune interactions in several solid cancers. However, its cellular distribution and relationship with the immune microenvironment in clear cell renal cell carcinoma (ccRCC) remain poorly understood. Here...

What can we learn on ALS pathophysiology from iPSC-derived motor neurons harbouring TARBDP mutations: a systematic review

The degenerating motor neurons of amyotrophic lateral sclerosis (ALS) patients are characterized by the accumulation of cytoplasmic aggregates, specifically enriched in ubiquitinated TDP-43. Expressed mainly in the nucleus and partially in the cytoplasm to execute its role in RNA...

Partial Mock‐Up–Guided Rehabilitation of Severe Tooth Wear: A Clinical Technique

ABSTRACT Objective This article describes a staged temporary occlusal protocol for selected patients with severe tooth wear and altered mandibular closure, illustrated through a clinical case. Clinical Considerations Advanced tooth wear may be associated with a protrusive mandibu...

Lifetime exposure to atypical working hours among healthcare professionals compared with the workforce in other sectors: Nationwide cohort study

Background Despite well-documented health risks, cumulative exposure to atypical working hours (AWH) over a career remains poorly quantified, especially among healthcare workers. Objectives This study aimed to compare career-long AWH exposure among healthcare professionals and ot...

Pathophysiological insights into ACO2-related inherited disorders through combined functional and multi-omic analyses of ACO2 patient-derived fibroblasts

ACO2 encodes the mitochondrial aconitase, involved in the second step of the tricarboxylic acid cycle. ACO2 variants cause isolated dominant or recessive optic atrophy, characterized by the degeneration of the optic nerves and leading to vision loss with high clinical heterogenei...

Optimizing the Ocular Surface Before, During, and After Glaucoma Surgery: A Narrative Review

This narrative review synthesizes the published literature on ocular surface disease (OSD) and glaucoma filtration surgery to develop practical, evidence-informed clinical and surgical recommendations for optimizing ocular surface management before, during, and after surgery. The...

Re-schooling as a major outcome of « therapeutic and schooling » programs for adolescents with obesity

Background School absenteeism is a frequent but underrecognized consequence of adolescent obesity, with long-term implications for social and professional integration. Objectives To assess changes in school attendance among adolescents with complex obesity before and after partic...

Dietary prevention of undernutrition reduces intestinal inflammation associated with an anti-inflammatory profile of gut microbiota in a preclinical model

Patients with inflammatory bowel diseases (IBD) have a high-risk for undernutrition. Undernutrition is associated with higher complications such as an increased mortality rate, a higher disease activity and an impaired quality of life in IBD patients. The aim of this study was to...

Co-design of a wheelchair-mounted robotic arm for functional autonomy: a Cybathlon case study in user-driven assistive robotics

Abstract Background Wheelchair-mounted robotic arms may support functional autonomy for individuals with upper-limb disabilities, but their long-term usability remains limited by the difficulty of matching high-dimensional robotic control to heterogeneous motor capabilities, dail...

Summary of Research: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer

This is a summary of a research article reporting the findings of the HER2CLIMB-05 trial (NCT05132582), a randomized, double-blind, placebo-controlled, international, phase III trial. The HER2CLIMB-05 trial was conducted to compare the efficacy and safety of adding tucatinib vers...

Anti-thymocyte globulin triggers TNF-dependent cell death in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) accounts for one of the most aggressive hematological tumors associated with poor prognosis, notably for relapsed and refractory patients. Hence, an unmet medical need persists for T-ALL patients who fail to durably respond to conventio...

Low intensity transcranial electrical stimulation for schizophrenia: a triple-blind, randomized, sham-controlled multicenter trial (STIM’Zo)

Persistent symptoms in schizophrenia remain a major therapeutic challenge. Noninvasive electrical stimulation such as transcranial random noise stimulation (tRNS) may alleviate auditory hallucinations and negative symptoms, although existing evidence is limited to case reports an...