Inserm

Autoantibodies neutralizing type I IFNs underlie ~5% of herpes simplex encephalitis in adults.

Inborn errors of type I interferon (IFN-I) immunity account for ∼7-8% of herpes simplex encephalitis (HSE) cases in young children, but the pathogenesis of HSE in adults is largely unknown. We report that IFN-I autoantibodies (auto-Abs) in serum/plasma samples drawn before, durin...

Determinants of failure of midazolam monotherapy during continuous deep sedation until death: evidence from a French cohort in a palliative care unit

Abstract Background Continuous deep sedation until death (CDSUD) is a legally regulated practice in France relying primarily on midazolam as first-line therapy. However, additional sedative agents are frequently required, and determinants of failure of midazolam monotherapy remai...

A family of small proteins links c-di-GMP riboswitch signaling with sporulation in Clostridioides difficile

Abstract Cyclic diguanosine monophosphate (c-di-GMP) is a second messenger that coordinates lifestyle transitions, virulence, and developmental processes in bacteria. In Clostridioides difficile , elevated c-di-GMP levels inhibit sporulation, but the underlying mechanism remained...

Ultrafast Micrometric Laser Structuring of Polymer Surfaces for Highly Organized Skeletal Muscle Tissue Modeling

ABSTRACT Engineered surface topographies have proven to be an efficient method to replicate in vitro the architecture of highly organized tissues by controlling the spatial arrangement of cells. In this work, we studied the ability to guide muscle cell development using femtoseco...

Protocol for integrative transcriptomic/metabolomic analysis: A case study on factors influencing the oyster-POMS disease

Deciphering the molecular mechanisms underlying complex biological interactions requires comprehensive approaches that capture these interactions across multiple regulatory and functional levels. Here, we present a protocol applied to the host-pathogen-environment interactions un...

Toward personalized exergaming: a machine learning-based decision-support approach to cognitive-motor training for long-term care residents with cognitive impairments

Abstract Background Major Neurocognitive Disorder (MND) is characterized by progressive impairments across multiple cognitive domains, leading to reduced autonomy, diminished quality of life, and frequent transition to long-term care facilities. Cognitive-motor exergames, which c...

A DNA methylation–based risk score improves prognostic stratification in myelodysplastic neoplasms

Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and variable risk of progression to acute myeloid leukemia (AML). Although mutational data are already implemented into the most recent MDS risk models, (i.e...

Rule‐Based Versus Generative Extraction of Psychological Symptoms From Forensic Medical Certificates: A Feasibility Study in the French ORFeAD Network

ABSTRACT Forensic medical certificates for victims of interpersonal violence describe psychological symptoms in unstructured prose, rarely explicit and requiring inference. To assess the feasibility of two extraction pipelines—rule‐based and a locally served generative large lang...

Transarterial embolization in musculoskeletal care: an indication-stratified narrative review

Abstract Background Transarterial embolization (TAE) is increasingly used across a broad spectrum of musculoskeletal conditions, ranging from established hemostatic and tumor-related indications to emerging pain-directed procedures for degenerative joint disease and chronic infla...

Wild-type and mutated ß-catenin differently repress RND3/RHOE expression in hepatocellular carcinoma

Tumor development and progression are mainly driven by oncogenic mutations but are also regulated by physical factors. Through its structural and transcriptional functions, ß-catenin is a key factor that acts on both aspects to promote liver tumorigenesis, leading to hepatocellul...

Pain Management in Older Adults: An Interprofessional Training Approach Assessed by Script Concordance Tests

ABSTRACT Background Optimal perioperative pain management in older adults challenges anesthesiologists due to increased drug sensitivity, altered pharmacokinetics, and limitations of pain assessment tools in cognitively impaired patients. This study evaluated whether a single 60‐...

Tools for providing information to patients about high-tech medical resources for treatment of cancer

BACKGROUND AND PURPOSE: High-tech medical resources play an increasingly important role in cancer diagnosis and treatment. However, accessing information about these technologies remains challenging due to their complexity and a lack of clear information pathways to obtain reliab...

Adenyl cyclase 6 is an evolutionary conserved chief regulator of peripheral nerve development and timely myelination in vertebrates

Myelination of large caliber axons by Schwann cells and clustering of ion channels at the nodes of Ranvier enables electrical impulses to propagate rapidly along axons in the peripheral nervous system (PNS). Although several in vitro studies have reported a role for the cyclic ad...

Unsupervised deep generative models for anomaly detection in neuroimaging: A systematic scoping review

Unsupervised anomaly detection (UAD) based on deep generative modelling has been increasingly investigated for identifying pathological brain abnormalities without requiring voxel-level annotations. By learning the distribution of healthy anatomy and generating pseudo-healthy rec...

Relapsed/refractory WAldenström macroglobulinemia patients treated by VEnetoclax with or without anti-CD20 antibody: WAVE a retrospective study of the French CLL/WM group (FILO)

Abstract Recently venetoclax (Ven) monotherapy showed promising efficacy for relapsed/refractory (R/R) Waldenström macroglobulinemia (WM), a population with significant medical unmet need. We report the efficacy and safety of Ven associated or not with anti-CD20 therapy, in a rea...

Platelet GPVI drives fibrotic lung remodeling

Platelets are a major reservoir of bioactive mediators, including growth factors such as transforming growth factor β1 (TGF-β1), that regulate vascular repair and tissue remodeling. Beyond these classical functions, platelets also participate in inflammatory hemostasis through ac...

Should We Still Care About the Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS) Transition? Evidence From a Systematic Review and Meta-Analysis

Objective Transition from Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS) represents a vulnerable period for transitional age youth (TAY), with high risk of disengagement and unmet needs. Evidence on effective transition models remains l...

Emotional Responses (Intensity/Valence) Fulfill RDoC Criteria but Remain Excluded From Diagnostic Classifications of Mood Disorders

OBJECTIVES: Categorical classifications of depression, such as DSM-5 and ICD, are limited by high clinical heterogeneity, arbitrary diagnostic thresholds, and weak links to underlying pathophysiology. In line with the Research Domain Criteria (RDoC) framework, this article propos...

Per- and polyfluoroalkyl substances in occupational settings: a review

Per- and polyfluoroalkyl substances (PFAS) are a large family of synthetic, persistent chemicals that are used extensively in various consumer products and industrial applications, yet there is currently no specific regulations in occupational settings. Here review the toxicity a...

Medication use during pregnancy in Europe and North America: a systematic review

To describe the mean number of medications used as well as the prevalence of medication use throughout pregnancy in Europe and North America, with a focus on use by trimester, type of medication, and use of harmful medications. A systematic review was performed searching MEDLINE,...