Inserm

Non-invasive multiparametric characterization of essential thrombocythemia, premyelofibrosis, and overt myelofibrosis

Among myeloproliferative neoplasms (MPN), prefibrotic myelofibrosis (preMF) was defined as a distinct entity from essential thrombocythemia (ET) and primary overt myelofibrosis (PMF) since the 2016 revision of the World Health Organization (WHO) classification, while precise char...

Renal Resistive Index Responsiveness to a Mean Arterial Pressure Test As a Guide for Mean Arterial Pressure Target in the Early Phase of Septic Shock: A Physiological Study

OBJECTIVES: Guidelines recommend targeting a mean arterial pressure (MAP) greater than or equal to 65 mm Hg in septic shock. Although experts advocate for individualized targets, no validated bedside tool exists. An increased renal resistive index (RRI) is associated with acute k...

Effectiveness of health mediation to promote organised cancer screening among underserved and under-screened populations in Marseille, France: findings from a repeated cross-sectional survey

Abstract Background Since 2022, the “13 en Santé” health mediation program has been implemented in Marseille, France, to reduce social health inequalities, in socioeconomically disadvantage neighbourhoods, with a particular emphasis on promoting participation in population-based...

Microglial maturation across human and mouse as a reference for interpreting large-animal models of perinatal brain injury

Abstract Microglia play dynamic roles in the developing brain and are central mediators of injury responses in perinatal brain injury. In mice, microglial gene regulatory and transcriptional programes reveal progression through early, pre-mature and mature stages. In contrast, mi...

Carbapenemase-producing Klebsiella oxytoca complex in France (2017–2023): Molecular epidemiology integrated with virulence and biofilm phenotypes

OBJECTIVES: This study analysed a large French collection of carbapenemase-producing Klebsiella oxytoca complex (KoC) isolates (2017-2023) to map species and carbapenemase distributions and identify emerging lineages. We further investigated virulence traits to understand the epi...

Melanocortin Receptor Signaling Modulates Anti-Obesity and Glucose Tolerance Effects of Hafnia alvei 4597 Probiotic Strain in Mice

The present study aimed to elucidate whether the metabolic effects of the probiotic bacterium Hafnia alvei 4597 depend on melanocortin receptor (MCR) signaling. The response to a 3-week intragastric treatment with the H. alvei bacterial suspension or total protein extract was com...

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...

FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors

Fibroblast growth factor receptor 3 ( FGFR3 ) is one of the most frequently altered genes in bladder cancer, primarily through activating mutations that drive oncogenesis and are enriched in luminal tumors. However, the underlying gene regulatory network (GRN) remains poorly char...

Nested contextual change and the temporal compression of episodic memory

Abstract How does the structure of events influence the when and the where of life experiences in comparison to the what? We developed a novel virtual reality (VR) environment to understand how the quantity of information within nested structures influence participants’ memory fo...

Pancreatic panniculitis as the sole manifestation of pancreatic ductal adenocarcinoma: a case report

Pancreatic panniculitis is a rare form of lobular panniculitis characterized by subcutaneous fat necrosis occurring at cutaneous sites distant from the pancreas. It is most often associated with pancreatitis, while pancreatic malignancies — dominated by acinar cell carcinoma — re...

Adipose tissue and myosteatosis measured by artificial intelligence as a predictor of overall survival in bladder cancer

Body composition may influence outcomes in muscle-invasive bladder cancer (MIBC), but its prognostic role remains unclear. In particular, the impact of adipose tissue distribution and muscle quality beyond BMI has been insufficiently studied. This study aimed to evaluate whether...

Genetic screening identifies WNT5A/RYK as a determinant of extracellular vesicle fate

Extracellular vesicles (EVs) are natural mediators of intercellular communication through the transfer of cytoplasmic material from donor to recipient cells. The molecular mechanisms governing EV uptake and cargo delivery in recipient cells remain largely elusive. To address this...

Behavioral changes preceded by subthalamic nucleus activity alterations in a progressive macaque model of Parkinson’s disease

Abstract Parkinson’s disease (PD) is diagnosed after motor symptoms appear, although non-motor symptoms emerge years earlier. Following years of pharmacological treatment, high-frequency stimulation (HFS) of the subthalamic nucleus (STN), a key hub in goal-directed behaviors, can...

Alcohol and tobacco in cancer: A unified framework of interaction across carcinogenic pathways and cancer types

Background Alcohol and tobacco are among the leading preventable causes of cancer worldwide and frequently co-occur. While both are well-established independent carcinogens, their combined effects remain insufficiently characterized and inconsistently interpreted across cancer ty...