Inserm

Medication use during pregnancy in Europe and North America: a systematic review

To describe the mean number of medications used as well as the prevalence of medication use throughout pregnancy in Europe and North America, with a focus on use by trimester, type of medication, and use of harmful medications. A systematic review was performed searching MEDLINE,...

Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study

BACKGROUND: Mogamulizumab, an anti-CCR4 monoclonal antibody used in advanced mycosis fungoides (MF) and Sezary syndrome (SS), also depletes regulatory T cells, potentially leading to immune-related adverse events (irAEs). Unlike mogamulizumab-associated rash (MAR), other irAEs re...

End-of-induction circulating tumor DNA outperforms conventional cellular MRD for predicting early progression in follicular lymphoma: an ancillary study of the RELEVANCE randomized trial

In this ancillary study of the RELEVANCE phase III trial (NCT01650701), we performed the first direct intra-patient comparison of circulating tumor DNA (ctDNA)-based versus cellular t( BCL2 / JH ) translocation-based MRD at end of induction (EOI) in 278 patients with advanced FL,...

Infection of urban rodents by SARS-CoV-2 in COVID-19 healthcare facilities in Brazzaville, Republic of the Congo

BACKGROUND: Considering the global increase of COVID-19 cases in the healthcare facilities between 2020 and 2021, and the widespread presence of pest rodents in Brazzaville, we conducted this study at the end of the pandemic peak to assess the potential for urban rodents to be in...

A Novel Striated Membrane Contact Site in Vestibular Hair Cells

The mammalian vestibular system has two types of sensory receptor hair cells (HCs), each with different neurotransmission mechanisms. Type II HCs use ribbon synapses to transmit neurotransmitters like glutamate to bouton terminals of afferent neurons. Type I HCs are nearly engulf...

Microbial metabolite p-cresol associates with constipation in adults with high-functioning autism spectrum disorder and induces constipation-like symptoms in mice

Abstract Gastrointestinal (GI) symptoms are prevalent in Autism Spectrum Disorder (ASD), yet their biological correlates remain poorly understood, notably in adults. The microbiota-derived metabolite p- cresol is reported to be elevated in the urine and stool of ASD patients, but...

Building-block synthesis as a determinant of antibiotic persistence

Reduced antibiotic target activity is a major driver of antibiotic treatment failure. While this has mostly been linked to the presence of low-energy bacteria, a recent study by Taher and colleagues suggests that reduced building-block synthesis can also promote antibiotic surviv...

Development and evaluation of a quality assessment tool for equality, diversity, and inclusion (QUALITY-EDI) within healthcare research

Implementing equality, diversity, and inclusion (EDI) in healthcare research is critical to ensuring findings are translatable and provide the greatest benefit to patients who need it most. A quality assessment scoring tool (QUALITY-EDI) was developed to evaluate the conduct of E...

SENIOR ‐ IPI : An easily applicable prognostic index for first‐line large B‐cell lymphomas patients >80 years treated with curative intent

Summary Using LYmphoma Study Association clinical trials combining 438 first‐line large B‐cell lymphomas (LBCL) patients >80 years old, we defined SENIOR‐IPI, an easily applicable prognostic index for this elderly population treated with an anti‐CD20‐miniCHOP (cyclophosphamide, d...

Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency

We provide a comprehensive phenotypic characterization of loss-of-function (LoF) variants in WDFY3 based on the largest cohort reported to date (n = 32). Our findings define a monogenic disorder marked by neuropsychiatric features (including autism and ADHD), mild to moderate neu...

Characterisation of the Novel HLA‐C*03:04:123 Allele by Sequencing‐Based Typing

ABSTRACT HLA‐C*03:04:123 differs from HLA‐C*03:04:01:02 by a single synonymous change in Exon 2.

BRET-Based Mitochondrial Subcompartment Localization Biosensors Reveal the Impact of Pesticides and Food Additives on Mitochondrial Protein Localization

Abstract The last decade has witnessed a marked increase in interest in mitochondria, whose dysfunction leads to the development of multiple diseases. Mitochondria are unique as they are highly compartmentalized organelles that are composed of two closely apposed membranes. Here,...

Impact of a Specialized Care Pathway for ICU Patients With Disorders of Consciousness: Observational Insights From an Expert Center

ABSTRACT Background Management of lasting disorders of consciousness (DoC) is complex and sometimes requires referral of patients to an expert team. We aimed to evaluate the impact of such specialized expert assessment through the description of a single‐center experience. Method...

Intensity and instability of affective and cognitive states in borderline personality disorder compared to remitted mood disorders and population-based controls: an Ecological Momentary Assessment study

Abstract Background Ecological Momentary Assessment (EMA) is one of the methods of choice for the evaluation of affective dynamics. Several studies have been conducted on the subject focusing on borderline personality disorder (BPD). However, most have only compared BPD to health...

Early insights into predicted efficacy of Ebola monoclonal antibodies for the 2026 Bundibugyo virus disease outbreak

The 2026 Bundibugyo virus disease (BVD) outbreak in the DRC and Uganda raises urgent questions about the efficacy of existing Ebola virus (EBOV) monoclonal antibodies (mAbs) against Bundibugyo virus (BDBV). Here, we perform genomic and structural analyses of 44 BDBV sequences, in...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

Palliative and end-of-life care on the battlefield: a scoping review

Abstract Background Modern conflicts have brought about a paradigm shift in military medicine. In Prolonged Field Care, recommendations have so far focused on damage control and care aimed at ensuring survival. But, particularly in large scale combat operation, not all patients w...

Deidentified data and analysis code for "LLM-assisted assessment item writing in medical education: a randomized pilot trial

This repository contains analysis code underlying the psychometric analyses of a randomized pilot study comparing LLM-assisted and conventional medical assessment item writing. It includes item-level psychometric outcomes, faculty-level aggregated outcomes used for exact permutat...

Large-scale electrophysiological signatures of Williams syndrome: evidence from oscillatory power and brain fluidity

Evidence suggests that Williams syndrome (WS) may be associated with atypical cortical oscillatory activity and large-scale structural and functional anomalies. However, links between whole-brain electrophysiological measures and cognitive performance in WS remain scarce. This st...