Inserm

Low-level of mitochondrial DNA alterations during direct-acting antiviral treatment in leukocytes of people who inject drugs living with HCV

Direct-acting antivirals (DAAs) have revolutionized hepatitis C virus (HCV) treatment, offering high cure rates and favorable safety profiles. However, concerns remain regarding their long-term mitochondrial safety, particularly among vulnerable populations such as people who inj...

PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12

Abstract Phosphoinositide 3-kinases (PI3Ks) are major regulators of cell growth, proliferation and signalling, constituting key therapeutic targets in cancer, inflammation, and other diseases. Individual class I PI3K isoforms control key cellular functions, imposing the need to g...

Increased CSF PKR activation in Alzheimer’s disease is associated with APOE4 genotype

Abstract Objective Protein kinase R (PKR) is a stress-activated kinase implicated in translational control, neuroinflammation, and neurodegeneration. Although increased PKR activation was reported in Alzheimer’s disease (AD), prior studies relied on semi-quantitative methods. Thi...

A multiregional serosurvey of RNA virus-reactive antibodies in bats and rodents reveals the enzootic presence of flavi- and paramyxoviruses in African Pteropodidae

Bats and rodents have been identified as reservoir hosts of diverse RNA viruses that pose potential risks to humans. However, overall virus prevalence in wildlife and underlying factors determining the zoonotic potential of reservoir-borne viruses remain poorly characterized. Vir...

Evolution of organ failures in allogeneic hematopoietic cell transplantation recipients admitted to the intensive care unit

The prognosis of allogeneic hematopoietic cell transplantation (HCT) recipients admitted to the intensive care unit (ICU) has been historically poor and a time-limited ICU trial may be considered in these patients with uncertain outcomes. How the evolution of organ failures over...

Reach and engagement in the ECAIL trial targeting socially disadvantaged families across the COVID-19 pandemic and cost-of-living crisis: A mixed-methods implementation study

Background The ECAIL trial, launched in 2017, was designed to evaluate a multicomponent intervention for childhood obesity prevention among hard-to-reach families. At a maternity hospital in Lille, France, healthcare providers screened pregnant women experiencing social vulnerabi...

Post-Nap Sleep Inertia in Narcolepsy Type 1 and Idiopathic Hypersomnia

Abstract Study objectives To compare post-nap sleep inertia between patients with idiopathic hypersomnia (IH) and narcolepsy type 1 (NT1) by assessing changes in subjective sleepiness and objective performance. Methods In 128 drug-free patients (50 IH, 78 NT1), standardized overn...

Autoimmune and inflammatory diseases associated with T-cell clonal expansion

Autoimmune and inflammatory diseases (AID) result from a breakdown of immune tolerance, often driven by T-cell dysregulation and sometimes associated with clonal T-cell expansion. While T-cell large granular lymphocyte leukemia (LGL-L) is a well-defined clonal disorder commonly a...

MOSAIC: Intra-tumoral heterogeneity characterization through large-scale spatial and cell-resolved multi-omics profiling

Understanding the tumor microenvironment has the potential to significantly advance precision oncology, but this effort has been hampered by the scarcity of consistent large data sets. Here, we introduce MOSAIC (Multi-Omics Spatial Atlas in Cancer), a multi-center clinical omics...

Digital solutions for tackling mental health in cancer patients and their families: The ALTHEA project

Despite advances in cancer treatment, the growing global cancer burden underscores the need for comprehensive and supportive care to address the needs of patients and their families. However, access to psycho-oncological support remains often limited across healthcare systems. Th...

Self-assembled nucleolipid G-quadruplexes act as multitarget decoys for oncogene suppression in pancreatic cancer

Abstract KRAS mutations drive multiple cancers and represent an important therapeutic target, together with other oncogenic regulators such as MYC , KIT , and BCL2 that are critically involved in pancreatic cancer. Here we describe a novel therapeutic strategy based on stable nuc...

How brain pulsations drive solute transport in the cranial subarachnoid space: insights from a toy model

Abstract Cerebrospinal fluid (CSF) circulates around and through the brain, supporting neural homeostasis by regulating the extracellular chemical environment. Yet, the physical mechanisms governing CSF-driven solute transport remain poorly understood, limiting the design of diag...

A cytidine deaminase biodegrader sensitises multiple cancer types to deoxycytidine analogue-based chemotherapies

Abstract Deoxycytidine (dC) analogues are widely used to treat solid tumours and blood cancers. However, their clinical efficacy is often limited by resistance mediated by cytidine deaminase (CDA), which converts these drugs into inactive metabolites. Existing CDA inhibitors have...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Health utilities in individuals with alpha-1 antitrypsin deficiency with and without COPD from the EARCO registry

Background Data on health utilities in Alpha-1 antitrypsin deficiency (AATD) are scarce. This study aimed to evaluate health-related quality of life (HRQoL) using the EQ-5D in a cohort of AATD Pi*ZZ individuals from the European AATD Research Collaboration (EARCO) registry and to...

Monitoring symptoms and performance in rehabilitation: Can we detect COPD exacerbation?

Background In patients with COPD, exacerbations mark disease progression, with significant reduction in quality of life and impact on mortality. Early detection is crucial to mitigate their consequences. The aim of this study was to investigate whether monitoring symptoms and exe...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Sensitive reverse transcription-digital droplet PCR-based discrimination of hepatitis delta virus RNAs reveals differential effects of interferon-α on viral RNA species

Hepatitis delta virus (HDV) replication relies on the production of distinct viral RNA species, including genomic (HDV-G), antigenomic (HDV-AG) and mRNAs (HDV mRNAs), which differ in abundance and function. However, the lack of sensitive and quantitative approaches allowing their...

European joint programme HBM4EU - Bridging science and policy: experiences and lessons learned from the key partners in the scientific steering of the initiative

The European Joint Programme HBM4EU was established to address politically relevant questions on chemical risks to public health through a targeted human biomonitoring research programme. Running from 2017 to 2022, it was co-financed by the EU's Horizon 2020 Research and Innovati...

Escherichia coli ST131 isolates are rare in human meningitis but belong to a distinct O25b-fimH22 clade B lineage shared with avian pathogenic Escherichia coli

Escherichia coli ST131 is a globally disseminated extraintestinal lineage best known for its resistance-driven expansion, yet it is rarely reported as a cause of neonatal meningitis. Whether specific ST131 sublineages retain neuroinvasive potential remains poorly understood. We a...