Inserm

Deep learning reveals ecological decoupling and rate heterogeneity in Hymenoptera wing evolution

Quantifying biomorphological evolution and integrating phenotypic data into large-scale ecological and evolutionary studies are often limited by the scalability, subjectivity, and poor interpretability of existing methods. We introduce HAIKA (Hierarchical Attention-based Interpre...

Electrophysiologic Demyelinating Features Are Common in Vasculitic Neuropathy: A Cohort of Biopsy‐Confirmed Cases

ABSTRACT Introduction/Aims Electrophysiologic features suggestive of demyelination have been reported in vasculitic neuropathy, complicating the diagnostic process, but their frequency is unknown. We aimed to determine the prevalence of demyelinating features, including fulfillme...

Cerebral No‐Reflow after Thrombectomy: International Delphi Consensus on Definition and Imaging Assessment

BACKGROUND: The operational definition and imaging assessment of the no-reflow phenomenon, a potential contributor to poor clinical outcome despite successful thrombectomy, remains debated. We aimed to develop expert-based international consensus on the definition, assessment, an...

Recurrent PDGFRB-Mutations in the Epithelioid Variant of Fibrous Papules

Fibrous papule (FP) is a common benign dermal mesenchymal lesion presenting as a solitary, dome-shaped papule mostly located on the nose. The morphologic spectrum is broad, and a number of variants have been described, including hypercellular, clear cell, pigmented, pleomorphic,...

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

Association between the site of emergency care and patient-centered outcomes in patients with cancer: rationale and design of the French COVER cohort

Patients living with cancer now account for a substantial and growing share of emergency department (ED) visits and carry a high burden of hospitalization and in-hospital death. Their acute presentations are frequently multifactorial - driven by disease progression, treatment tox...

Unraveling Vulnerabilities and Pathways Responsible for AITL Malignancy to Improve Patients’ Treatment

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphoma characterized by poor clinical outcomes following conventional CHOP-based chemotherapy and the lack of effective disease-specific therapeutic options. The disease finds its origin in...

Prognostic performance of the systemic immune-inflammation index in hospitalized patients with COVID-19: a multicenter emergency department study

Abstract Introduction The systemic immune-inflammation index (SII) has been proposed as a simple prognostic biomarker in COVID-19, but its performance relative to routinely available inflammatory markers and its incremental value beyond clinical predictors remain uncertain. We ev...

Hackathon on predictive modelling in systems pharmacology: design, implementation, and outcomes

Background The growing availability of multi-omics data and machine learning methods creates both an opportunity and a challenge for the systems pharmacology community: the opportunity to model drug action at unprecedented mechanistic resolution, and the challenge of equipping a...

Guidelines for Decisions to Withhold or Withdraw Life-Sustaining Treatments (LST) in Adult ICU

OBJECTIVE: The French Society of Anaesthesia and Intensive Care Medicine (Société française d'anesthésie et de réanimation, SFAR) and the French Society of Physical Medicine and Rehabilitation (Société Française de Médecine Physique et de Réadaptation (SOFMER)) aimed at providing...

Serotype-independent inhibition of S. pneumoniae by SMiTE, a commensal-derived bacteriocin

ABSTRACT Streptococcus pneumoniae remains a leading cause of disease despite widespread vaccination, highlighting the need for serotype-independent strategies. We recently identified commensal streptococci that produce bacteriocins with anti-pneumococcal activity. Here, we evalua...

Natural History of Rare Tumor Risk Syndromes: A Scoping Review to Inform Cost-Effectiveness Models

Background Hereditary cancer syndromes account for approximately 10% of all cancers. Many of these, classified as rare tumor risk syndromes (RTRS), lack comprehensive data on natural history, lifetime cancer risk, and the long-term impact of surveillance. These evidence gaps limi...

Association Between a 3D ‐Printed Simulation Model and Self‐Assessed Confidence in Dental Trauma Management

ABSTRACT Introduction and Aim Simulation‐based learning using 3D‐printed models offers a promising approach to improve confidence in complex procedures. Dental trauma can lead to severe functional and esthetic consequences if not managed promptly and effectively. This study aimed...

Metformin reverses lymphatic mitochondrial dysfunction induced by 5-FU chemotherapy

Abstract In western countries, secondary lymphedema often occurs after cancer treatments. However, lymphedema appears months, sometimes years after treatment suggesting that it is not only a side effect of surgery and may be promoted in part by cancer treatments. In this study, w...

HCV incidence and prevalence trends among people who use drugs in France 2004 to 2023

Abstract Hepatitis C virus (HCV) remains a key public health challenge, particularly among people who use and inject drugs (PWUD, PWID). While direct-acting antivirals (DAA) have revolutionized HCV treatment, meeting the WHO’s 2030 elimination target requires accurate estimation...

Hypoxic Burden Is an Important Determinant of Height in Nonobese Children With Sleep‐Disordered Breathing

ABSTRACT The relationship between linear growth and obstructive sleep‐disordered breathing (SDB) has not been extensively studied. Hypoxic burden (HB) is a new metric that may better capture end‐organ damage in paediatric SDB compared to the traditional apnea‐hypopnea index (AHI)...

Opioid use, disability, and patient‐reported cognitive impairment in migraine: Multi‐country results from the Chronic Migraine Epidemiology and Outcomes—International Study

OBJECTIVE: To characterize the population who do and do not use opioids to treat migraine in the Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) Study. BACKGROUND: Opioids are not recommended for migraine treatment because of efficacy and safety limitations. ME...

Sepsis in the major burn patient

Abstract Background Sepsis in the context of major burn injury presents a significant challenge to clinicians. It affects a substantial proportion of patients with major burn injury and is the leading cause of death in those that survive to hospital. Due to the complex and profou...

CD8⁺ T Cell infiltration and spatial organization in cancer: mechanisms, barriers, and therapeutic strategies

Abstract The infiltration of tumors by CD8⁺ T lymphocytes is a critical determinant of antitumor immunity and response to immunotherapy. However, the presence of tumor-specific CD8⁺ T cells does not necessarily translate into effective tumor control, as multiple biological barrie...

MAC-explorer: bridging genome-based taxonomy and an identification tool for the Mycobacterium avium complex

The Mycobacterium avium complex (MAC) comprises genetically close nontuberculous mycobacteria responsible for human and animal infections worldwide. Increasing availability of whole-genome sequencing (WGS) data offers new opportunities for genomic surveillance and lineage trackin...