Imperial College London

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

GFN1-xTB-AssistedMachine Learning for ElectronicStructure Screening of Metal–Organic Frameworks

Abstract Metal–organic frameworks (MOFs) are versatile materials with tunable crystal structures, morphologies, and chemistries, offering diverse physical and chemical properties. Although typically electrically insulating, specific combinations of organic and inorganic component...

Insecticide resistance profile and efficacy of next-generation LLINs against pyrethroid-resistant Anopheles gambiae s.l. in M’bé, central Côte d’Ivoire

Long-lasting insecticidal nets (LLIN) combining pyrethroids with synergists or partner insecticides represent the next-generation tools for controlling malaria transmitted by resistant vectors. Because of their differing modes of action, their deployment in a given area would req...

Benefits and challenges of a Patient & Public Involvement (PPI) peer researcher

Involving a patient and public involvement (PPI) peer researcher with lived experience in clinical research is a relatively new concept and to our knowledge, has not been described in adult cardiac surgery. The integration of a PPI peer researcher with a lived experience of a sur...

Multimodal graph-based classification of esophageal motility disorders

PURPOSE: Diagnosing esophageal motility disorders, including dysphagia, pose significant challenges due to the complexity of high-resolution impedance manometry (HRIM) data and variability in clinical interpretation. Thiswork explores the feasibility of a multimodal machine learn...

Mapping System Vulnerabilities in Anaesthesia Safety: A Role‐Based Inquiry in Response to Fatal Fungal Meningitis Outbreaks in Mexico

ABSTRACT Objectives Unsafe anaesthesia practices in Mexico have contributed to repeated outbreaks of fatal fungal meningitis, exposing broader health system vulnerabilities. This study aimed to analyse how structural weaknesses in perioperative care, spanning governance, workforc...

Identification of a key water molecule involved in the macrophage migration inhibitory factor‐catalyzed tautomerization of para ‐hydroxyphenylpyruvate using neutron crystallography

Neutron crystallography was used to determine a 2.5-Å resolution all-atom structure of macrophage migration inhibitory factor (MIF) interacting with 3-(4-hydroxyphenyl)-pyruvate (HPP). MIF is a pro-inflammatory, pro-tumorigenic protein that may be an attractive therapeutic target...

Developing Low-Carbon Concrete from Recycled Wind Turbine Blades: Fresh and Short-Term Properties

Abstract This study investigates the fresh and short-term properties of supplementary cementitious materials (SCMs) derived from retired wind turbine blades, specifically glass fiber–reinforced polymer (GFRP) and GFRP after thermal degradation treatment (GF550), with fly ash (FA)...

Glacier surges on James Ross Island, Antarctica, and their relationship with climate

Abstract. Although the Antarctic Peninsula has a similar climate to that of other regions hosting surge-type glaciers, only one glacier surge has been previously observed in this region. We examined ice surface velocity, elevation and terminus position changes of Antarctic Penins...

Diffusion in deforming semi-permeable media: a Monte Carlo random walk approach

Abstract Diffusion processes in deforming media with semi-permeable barriers are fundamental to understanding many biological and physical systems. The presence of semi-permeable barriers causes temporal and spatial departures from normal diffusion. We present an analytic express...

Phenomic Medicine and Metabolic Disease Trajectories: Measuring and Modelling the Health to Disease Continuum

Abstract Phenomic medicine is an emerging field that involves measurement and modelling of multidimensional phenotypic data to provide a systems-level framework to understand how health and disease evolve over time and inform decision making in a clinical context . Unlike genomic...

Modelling the effects of travel time use on mode choice and the value of travel time savings: tackling self-selection and endogeneity bias

Preferences for travel-based activities may lead individuals to choose travel modes that best accommodate activity needs. In theory, “passengerised” modes, such as public transport and automated vehicles (AVs), could become the preferred travel options, as they enable a wider ran...

The mirrored burden and accountable handovers in cancer survivorship: co‑designing a post‑treatment transition standard

Post-treatment transitions after active cancer care often lack clear ownership, timelines and closure rules, shifting coordination work onto survivors and staff. We aimed to identify how these failures arise and to co-design a handover standard for post-treatment survivorship car...

Ligase enzymes for the synthesis of peptide therapeutics

Peptides are widely used as therapeutics and in many other important applications. However, current chemical synthesis of peptides is highly step- and atom-inefficient, requiring deleterious reagents and solvents, which creates harmful waste. Alternative methods for more sustaina...

Spatiotemporal patterns of ambient NO2 and NO pollution in Kigali Rwanda

Abstract Kigali, like many cities in sub-Saharan Africa, faces rapid urban growth alongside the need to manage air pollution and protect public health. Despite its policy efforts, systematic data on nitrogen oxides (NO x : NO 2 and NO), key indicators of combustion-related pollut...

Determinantal Diophantine Linear Algebra: Foundations and Lorentz--Fermat Factorization

We propose \emph{determinantal Diophantine linear algebra} as a systematic framework for integer and rational solutions of prescribed-determinant equations inside affine linear families of matrices. A datum consists of an integral affine matrix pencil\[ \mathcal A(\mathbf x)=A_0+...

Determinantal Diophantine Linear Algebra: Foundations and Lorentz--Fermat Factorization

We propose \emph{determinantal Diophantine linear algebra} as a systematic framework for integer and rational solutions of prescribed-determinant equations inside affine linear families of matrices. A datum consists of an integral affine matrix pencil\[ \mathcal A(\mathbf x)=A_0+...

EFECT enables reliable and reproducible stochastic simulations across disciplines

Stochastic simulations underpin computational research in fields from systems biology and epidemiology to finance and physics-informed machine learning, yet their reproducibility is hard to quantify because each run yields different outcomes. Existing practices to improve computa...

The Zooplankton International Geospatial dataset: A global repository of spatiotemporal freshwater zooplankton community composition data from lakes and reservoirs to support ecological research

Abstract Zooplankton transfer substantial energy in aquatic food webs and are used as indicators of environmental change. Syntheses of zooplankton community dynamics globally require datasets that span a wide range of environmental gradients; however, these datasets are limited d...

Global trade-offs between consumption, carbon prices and equity

As the remaining carbon budget continues to dwindle, economic growth strains efforts to limit global warming to 1.5 °C. Reducing unnecessary production and consumption in high-income regions and among the wealthy, and organising production more around human needs and human well-b...