Imperial College London

Age-Specific Ultrasound Reference Data for the Laterolateral Rectal Diameter in Healthy Children

Background: Transabdominal ultrasonographic measurement of rectal diameter is increasingly used as a non-invasive adjunct for assessing rectal distension and fecal loading in children. However, interpretation is limited by the lack of age-stratified reference data in pediatric po...

Digital health capacity building across health workforce and education sector in the WHO European region

Abstract Disparities in digital capacity building across countries highlight the need for global upskilling. This study examined digital health capacity building across policy, workforce, and pre-service education domains across 53 countries of the WHO Europe Region. This was a c...

Linearization-Based Feedback Stabilization of McKean−Vlasov PDEs

Abstract. We develop a feedback control framework for stabilizing the McKean–Vlasov PDE on the torus. Our goal is to steer the dynamics toward a prescribed stationary distribution or accelerate convergence to it using a time-dependent control potential. We reformulate the control...

Dynamics of human cardiogenesis and its disruption in trisomy 21

Abstract Developmental dynamics involve the specification of diverse cell types and their spatial organization into multicellular niches 1 . Here we combine single-cell and spatial multiomics to define 21 distinct tissue niches in the developing heart, which we use to develop a c...

AI-assisted discovery of an ABCA1/ABCG1 activator for restoring mitophagy and mitigating Alzheimer’s pathology

Abstract Defective mitophagy is a key pathological risk of Alzheimer’s disease (AD), yet available pharmacological agents capable of restoring mitophagy remain clinically limited, largely due to the lack of tools for drug screening and target identification. To address this, we i...

Combat Injury, Limb Loss, Traumatic Brain Injury, and Psychosocial Outcomes Among Military Personnel

Importance Given the burden and rising number of injuries from recent conflict zones such as Ukraine and the Middle East, understanding the long-term health outcomes of those with physical traumatic injuries is critical. Objective To investigate psychosocial outcomes among UK mil...

Adults with congenital heart disease: the growing impact of acquired cardiovascular risk factors on late mortality.

BACKGROUND AND AIMS: With improved survival, adults with congenital heart disease (ACHD) increasingly face acquired cardiovascular risk factors; however, their impact on late mortality remains incompletely defined. This study aimed to evaluate the contribution of acquired cardiov...

Multi-omics analyses reveal key immunological and metabolic correlates of mortality in HIV-associated Pneumocystis pneumonia

Pneumocystis jirovecii pneumonia (PCP) remains a major cause of life-threatening respiratory failure in people with advanced HIV, yet the biological factors associated with mortality are incompletely understood. We performed integrated transcriptomic, proteomic, and metabolomic p...

Burden assessment tools in epilepsy caregiving: A scoping review

Background Informal caregivers of people with epilepsy (PWE) experience a substantial burden because of the chronic nature and unpredictability of seizures. Although several caregiver burden assessment tools are available to quantify this burden, little is known about which of th...

Radiomics machine learning models for lung cancer early diagnosis in heterogenous multicentre chest CT data: LIBRA study results

Abstract Objective We developed and validated radiomics models for lung cancer prediction in indeterminate pulmonary nodules that retain performance in heterogenous data from multiple centres. Materials and methods The retrospective Lung Imaging Biobank for Radiomics and AI (LIBR...

Exploring the relationship between gut microbiota and pan-cancer: a meta-analysis of Mendelian randomization studies

The relationship between the gut microbiota and cancer is of increasing interest, but remains incompletely understood. This study synthesized evidence from Mendelian randomization (MR) studies to assess the association between genetically predicted gut microbiota abundance and pa...

Cell-Based and Cell-Derived Therapies Delivered During Ex Vivo Machine Perfusion for Solid Organ Reconditioning Prior to Transplantation: A Systematic Review

Background/Objectives: Organ shortage is a major barrier to transplantation, leading to the emergence of marginal donor organs and extended criteria donor grafts and, alongside these, machine perfusion as a platform for reconditioning grafts to meet transplantation standards. Des...

Loop engineering and activity improvement of TEV protease by a phagemid-based selection system

Abactstr Loop engineering of enzymes remains challenging due to high flexibility and conformational complexity, posing a bottleneck for deep-learning-based design. Here, we constructed mutant libraries for three loops of TEV protease to assess combining directed evolution with de...

Orthotropic plate buckling method for the design of stainless steel structures manufactured by wire-arc directed energy deposition

Wire-arc directed energy deposition (DED-Arc) offers significant advantages for manufacturing stainless steel plates, but the inherent material anisotropy of DED-Arc stainless steel challenges the isotropic assumptions underlying current design standards (e.g., AISC 360, EN 1993-...

Universal performance improvements in CuSCN-based devices enabled by CuBr2 doping: Transistors, solar cells, and photodetectors

Copper(I) thiocyanate (CuSCN) has become one of the standard hole-transport layers (HTLs) for an ever-expanding range of device applications. However, solution-processed CuSCN films suffer from hole-trapping SCN − vacancies (V SCN ) and limited p-type conductivity. Herein, we sho...

How Brokers Enable Collective Identity Formation in Fragmented Industry Groups: The Case of Franciacorta Wineries

Abstract This study illuminates the role of brokers, that is, actors spanning inter‐organizational boundaries, in the process of collective identity formation in fragmented industry groups. Through an in‐depth longitudinal analysis of the Franciacorta wineries from the 1960s to t...

The impact of molecular transport in turbulent non-premixed NH3/H2/N2 jet flames at elevated pressures

The modelling of turbulent combustion of ammonia is particularly challenging due to the complex chemistry featuring an exceptionally wide range of primary chemical time-scales demanding accurate inclusion of turbulence–chemistry interactions. The latter are here treated using a t...

Glucagon‐Like Peptide‐1 Receptor Agonists in Pregnancy: Periconception Exposure and Perinatal Outcomes

ABSTRACT Objective An increasing number of women of childbearing age worldwide are using glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and are advised to use effective contraception during treatment. Nevertheless, maternity services are encountering increasing numbers of...

Protocolised analgosedation in mechanically ventilated adult patients: A scoping review

Purpose Our objectives were to assess structure and content of analgosedation protocols used for mechanically ventilated adult patients, including those receiving extracorporeal membrane oxygenation (ECMO), against current international sedation guidelines, and to explore reporte...

Factors associated with loneliness and social capital in a large volunteer sample of adults in England

Abstract Background Loneliness is a pressing public health concern with wide-ranging impacts on mental, physical and social wellbeing. Building on the Measuring Loneliness in England (INTERACT) Study which represents one of the largest volunteer-based studies of loneliness and so...