Imperial College London

Momentum-based access and speed control for improved safety in heterogeneous road networks

The increasing variety of means of transportation, including light vehicles like e-scooters and e-bikes, together with the increasing weight of conventional vehicles due to electrification and consumer preferences for SUVs, are raising serious concerns regarding the safety of roa...

Comparing the readability of AI-generated and society-authored patient information leaflets in orthopaedics

Abstract Introduction Effective patient education is critical in orthopaedic care, influencing satisfaction, adherence, and outcomes. Artificial intelligence (AI), particularly large language models (LLMs), could offer the potential to improve patient information leaflets (PILs),...

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...

Eccentric compressive behaviour of horizontal circumferential joints in concrete wind turbine towers considering joint opening

Horizontal circumferential joints are critical load-transfer regions in the concrete segments of steel–concrete hybrid wind turbine towers. However, existing studies and design methods generally treat the annular concrete section as a continuous member and do not explicitly consi...

Latent paths in mode choice models: incorporating street-level environment features for active travel policy

There is growing empirical evidence that walking and cycling are influenced by street-level environment features such as greenness and traffic stress. To assess active travel policy, these features are increasingly incorporated into mode choice models through predictors that aggr...

Optimal canopy light-use strategy shapes global greenness dynamics

“Greenness” is a key indicator of the functional state of vegetation. However, the physiological processes behind seasonal patterns in greenness are diverse and incompletely understood, hindering the predictability of climate-driven shifts in global foliage phenology. Optimality...

Dissecting Anomalies in Conditional Asset Pricing

This paper introduces a novel methodology for analyzing anomalies in conditional asset pricing models with time-varying risk exposures and premia. Our approach extends the conventional two-pass methodology to include both ordinary and weighted least-squares estimation in a condit...

To stall-cell or not to stall-cell: Variational data assimilation of 3D mean flow past a stalled airfoil

The full-field reconstruction of three-dimensional (3D) turbulent flows from sparse experimental measurements remains a significant challenge, particularly for flows exhibiting complex 3D flow separation. In this work, we address this challenge for the case of stall cells - spanw...

Bayesian model discovery for reverse-engineering biochemical networks from data

Abstract The reverse engineering of gene regulatory networks based on gene expression data is a challenging inference task. A related problem in computational systems biology lies in identifying signalling networks that perform particular functions, such as adaptation. Indeed, fo...

Strong Lead‐Free Bioinspired Piezoceramics for Durable Energy Transducers

ABSTRACT Durable, high‐performance, and environmentally friendly lead‐free piezoceramics are essential for next‐generation sustainable energy transducers and electromechanical systems. However, piezoceramics are mechanically weak, which negatively impacts their working conditions...

Comparison of local, regional and general anaesthesia on surgical outcomes in arteriovenous fistula creation

Dialysis is essential for patients with end-stage renal disease and arteriovenous fistula (AVF) surgery creates access for high flow dialysis. This review examines the effects of local, regional and general anaesthesia on AVF outcomes, drawing on studies from 2014 to 2024. Region...

Factors for Success and Failure of Allergen Immunotherapy ( AIT ) Trial Design in the Light of Evidence‐Based Medicine: Current Aspects 2026

Allergen immunotherapy (AIT) has been acknowledged as the only disease-modifying treatment for respiratory diseases since its introduction in 1911. Although the efficacy and safety have convincingly been established in numerous randomized clinical trials (RCTs), the AIT study res...

Practices of community pharmacists towards COVID-19 treatment in Vietnam: a simulated client study

<title>Abstract</title> Background Recent reports have raised concerns about drug overuse and misuse in self-medication practices for COVID-19 treatment. This study was aimed to assess the availability and appropriateness of medication dispensing provided by community pharmacists...

Digital exclusion and health in older adults: a systematic review

Abstract Healthcare systems are turning increasingly digital. Digital exclusion restricts access to a wider range of health-related resources among older adults, which delays prevention and treatment, posing additional health challenges. The study aims to systematically review th...

How Microscale Flowand Vapor Transport Shape NewParticle Formation and Growth

Abstract Accurate simulation of atmospheric new particle formation (NPF) remains limited because large-scale models cannot resolve aerosol processes at fine spatial scales, while detailed microphysics models assume spatially homogeneous conditions. Here we use a high-resolution t...

Defining ‘psychedelic’

Humphry Osmond coined the term ‘psychedelic’ in 1956, conjoining ‘psyche’ for ‘soul’ and ‘delic’ for ‘to manifest’ or ‘illuminate’. Soul-illumination is a compound noun that describes a psychological state or process. Osmond intended for it to be a taxonomic noun—naming, not just...

Selective Neuronal Vulnerability to Alpha-Synuclein Pathology in Parkinson’s Disease: A Critical Review of Mechanistic Rationale and Biomarker Stratification

Background: Parkinson’s disease (PD) exhibits remarkable clinical heterogeneity, with substantial variability in motor progression, cognitive decline, and the development of non-motor manifestations. Although the propagation of pathological alpha-synuclein is considered a central...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Artificial Intelligence-Assisted Systematic Literature Reviews in Metabolic Phenotyping: A Methodological Framework and Validation Study

Abstract Systematic literature reviews are widely acknowledged to be at the top of most evidence hierarchies but are very time-consuming and labour-intensive. The advent of artificial intelligence (AI) offers possibilities to accelerate the review process. We propose a systematic...

Revisiting Obesity Definitions: Impact of the 2025 Lancet Commission Criteria on Obesity Prevalence Among People With MASLD

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.