Cornell University

Comparison of Plasma Protein Fractions and Electrophoretograms in Non‐Laying and Egg‐Laying Domestic Chickens

BACKGROUND: Protein electrophoresis (EPH) is a valuable diagnostic tool in veterinary medicine, particularly in non-mammalian species where albumin measurement has historically been considered inaccurate by routine biochemistry analyzers. Physiologic processes such as egg-laying...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...

Post-Craniotomy Headache: Current Concepts and Emerging Procedural Therapies

Post-craniotomy headache (PCH) is a common complication following neurosurgery, yet there remains limited consensus regarding the mechanism, classification, and optimal management. This review summarizes the current literature and highlights recent trends in procedural therapies....

Remote Sensing and Machine Learning for Monitoring Soil Nitrogen Dynamics and Crop Nitrogen Status in Field Conditions

Efficient nitrogen (N) management is essential for sustaining crop productivity while minimizing environmental impacts associated with nitrogen losses. However, the high spatial and temporal variability of soil nitrogen dynamics and crop nitrogen status makes field-scale monitori...

Highly localized droplet clustering in shallow cumulus clouds

The size and spatial clustering of water droplets in warm clouds influence cloud evolution and radiation properties and thus are of fundamental importance for the Earth’s energy balance and water cycle. Some proposed mechanisms for droplet growth and precipitation initiation in w...

What Does It Mean to Be Black? Experimental Evidence on the Situational Deployment of Racial Schemas

How do Black Americans construct narratives about the meaning and boundaries of Blackness in America today? We leverage an original, nationally representative survey experiment among U.S.-born Black Americans ( n = 3,100) to examine (1) justifications used to validate or reject a...

Hypertension Management in Pregnancy and Postpartum

Abstract Hypertensive disorders of pregnancy affect approximately 9% of pregnancies in the United States and are a leading cause of maternal morbidity and mortality. For nephrologists, these conditions sit at a critical intersection: chronic kidney disease is among the strongest...

Mechanical Profiling by AFM Enables Real-Time Readoutof Endothelial Cell State

Abstract Atomic force microscopy (AFM) provides quantitative capabilities for mapping the mechanical properties of living cells with nanometer resolution, yet its potential for monitoring a range of cell mechanical states remains largely underexplored. Here, we employed AFM to ma...

Generation and Enhancement of Persistent Nanoscale Magnetization in All‐Dielectric Metasurfaces by Optically Injected and Localized Free Carriers

Time-varying dielectric metasurfaces that support sharp optical resonances with nontrivial electromagnetic field distributions constitute a unique platform for realizing temporal interfaces for metasurface-guided waves (MGWs). Rapidly changing metasurface resonance enables freque...

Hospice Care in the Era of AI : Hospices' Views on Data‐Driven Tools to Support Live Discharge Decisions

BACKGROUND: Live discharge occurs for 20% of hospice enrollees, resulting in loss of support and disruptive care transitions, with higher risk for patients with Alzheimer's disease and related dementias (ADRD). Little is understood about how data-driven clinical decision support...

Computational analysis of a high-density electrode to scale the electric field geometry and intensity for neurostimulation

High-density grid electrodes can be configured to spatially scale the neurostimulation fields and enable the control of depth, intensity, and stimulation vectoring. In this study, we computationally analyze a high-density cluster electrode (HDCE) technology to measure its scalabi...

The cGAS/STING pathway in cancer: translating innate DNA sensing into therapeutic potential

The cGAS/STING pathway is a central innate immune DNA-sensing system that links aberrant DNA species to innate immune and stress-response transcriptional programs and has emerged as a key regulator of tumor-immune interactions. In cancer, pathway outputs are shaped by interconnec...

Comparisons of Novel Risk Stratification Models to the Current cT1a/b Staging in Incidental Prostate Cancer

OBJECTIVE: Incidental prostate cancer (PCa) patients are currently stratified to either cT1a vs. cT1b stage, depending on tumor volume (< 5% vs. > 5%) in the resected tissue. We tested for other models that could improve cancer-specific survival (CSS) predictions. METHODS: Incide...

JNK and p53 cause human and mouse β cell death during excessive unfolded protein response

Endoplasmic reticulum (ER) stress contributes to β cell death in both Type 1 and Type 2 diabetes (T1D and T2D). However, the molecular mechanisms driving β cell death during ER stress remain insufficiently defined, limiting development of protective therapies. GRP78, an ER chaper...

Multi-scale evapotranspiration and evaporative stress as indicators of vegetation health and drought response – an application in central Missouri, USA

Satellite estimates of evapotranspiration (ET) based on thermal infrared retrievals of land-surface temperature enable monitoring of vegetation water use and health/stress at sub-field to global scales. The information content of these products varies with pixel size, reflecting...

Spatially defined IGF1R-STMN1 axis delineates a metastatic cell state in osteosarcoma

Abstract Metastatic osteosarcoma (OS) remains the leading cause of disease-related mortality, yet effective therapies are still lacking. Here, we integrated single-cell RNA sequencing, spatial transcriptomics, and functional assays to investigate signaling dependencies in OS meta...

Four years on: following the pathway to real world impact of engineering research

Here we present five short case studies in which key authors of papers originally published in Communications Engineering in 2022 describe the impact of their work four years on. These reflections provide a glimpse of what the papers meant for the key researchers involved, their...