Chinese Academy of Sciences

Metal–Organic Framework MIL-101 Induces Macrophage Ferroptosis through Depriving Cystine Uptake and Overloading Labile Iron Pool

Abstract The wide applications of metal–organic frameworks (MOFs) in environmental remediation and biomedicine inevitably lead to their entry into the environment and human body, exerting unexpected risks. Recent studies have primarily focused on the cytotoxicity testing of MOFs;...

Retinal Microvascular Abnormalities, White Matter Injury, and Cognitive Impairment in Carotid Stenosis or Occlusion

Background Severe carotid artery stenosis or occlusion (CASO) is associated with white matter injury and cognitive impairment, but markers of accompanying microvascular dysfunction remain incompletely characterized. We investigated the relationships among retinal microvascular ab...

Spatiotemporal Patterns and Driving Factors of Water Self-Purification Capacity in the Source Area of the Western Route of the South-to-North Water Diversion

The water self-purification capacity in the source area of the Western Route of the South-to-North Water Diversion Project of China was investigated. This research aimed to promote the coordinated development of water source protection and water diversion benefits. Based on water...

Machine Learning-Assisted Key Toxicant Identification from Mass Spectra: A Case Study of AhR Agonists in Polypropylene Face Masks

Abstract Identifying key toxicants that drive biological effects in complex samples remains a major challenge for environmental analytical chemistry. Here, we developed an AhR-oriented machine-learning model, EIMSFrag-AhR, to predict AhR agonistic activity directly from GC-EI-MS...

Automated Construction of Geospatial Analysis Workflows: Recursive Solving of Elementary Modeling Questions Adaptive to Workflow Construction Contexts

ABSTRACT Geospatial analysis workflows are widely used to address complex geographic problems, but their construction is challenging due to dynamic contextual factors like the characteristics of the study area, geo‐models, and datasets during construction process. Current automat...

Proteoform-Resolved Interaction Mapping of Target Protein Complexes in Living Cells via Tracelessly Releasable Cross-Linking

Abstract Proteoform-resolved interaction analysis is critical for understanding the functional diversity of multiple proteoforms from the same gene and their complexes. However, current technologies are still limited in resolving in vivo interactions at the proteoform level. In v...

Numerical analysis of the fluid flow and heat exchange characteristics in a low-temperature and high-permeability reservoir of a heat storage and heating system

It is a promising energy strategy to utilize a shallow, low-temperature geothermal reservoir for seasonal heat storage and heating, with the potential to meet winter heating needs in decentralized rural buildings. The fluid flow and heat exchange in the reservoir govern the therm...

Integrated Multimodal Fusion Network and Multispectral Sensing Photoelectrochemical Platform for Sweat Glucose Monitoring

Abstract Sweat glucose detection offers the advantages of being painless, noninvasive, and suitable for continuous monitoring, showing broad application prospects in diabetes management. However, a single sweat glucose detection method cannot meet the requirements of multiscenari...

Persistent Mn 3+ Sites on Reduced MnO Enable Efficient Syngas Conversion

ABSTRACT Mn‐based materials are widely used for syngas conversion, where MnO is generally regarded as the catalytically active phase under reducing conditions. Yet catalysts derived from different Mn oxide precursors often exhibit markedly different performances despite evolving...

Birch-Type-Reduced Carbazole Anions Enable Redox-Adaptive Super-Reducing Photocatalysis

Abstract Photocatalytic activation of inert chemical bonds is constrained by the redox potential of the catalyst. Here, we report a redox-adaptive photocatalytic strategy in which an electron-rich carbazole photocatalyst, CBZ6, functions as a molecular redox transformer through t...

Trajectory-SAM: Object Trajectory-Guided Segmentation for Remote Sensing Videos

The rapid proliferation of high-resolution remote sensing video (RSV) has made object segmentation an increasingly critical yet challenging task. Existing methods face two fundamental limitations in this domain: (1) the intrinsic complexity of RSVs arising from diminutive object...

A two-stage cascaded prediction framework for urban inundation depth using a dual-branch CNN-ConvLSTM network

Study region Shenzhen, China, is a densely urbanized subtropical megacity characterized by extensive impervious surfaces, rapid runoff responses, and frequent rainfall-induced inundation. Study focus To address the underestimation of urban inundation depth driven by severe zero-i...

Graphene-Like-Armored Nanosheet Assemblies toward Fast and Stable High-Mass-Loading Sodium Storage

Abstract Sodium-ion batteries represent promising energy storage devices, yet their deployment is severely hampered by sluggish ion-transport kinetics and unstable electrode–electrolyte interfacial chemistry that deteriorate rate capability and cycling lifespan, particularly unde...

Unusual Switch of Cell Death Mode by Docosahexaenoic Acid (DHA) via Enhancing Endoplasmic Reticulum Peroxidation Induced by Lipophilic Iron Complex

Although ferroptosis is a programmed iron-dependent cell death, many lipophilic iron complexes fail to induce ferroptosis through iron overload. The underlying mechanisms remain unclear. Here we found that a typical lipophilic iron complex 8-hydroxyquinoline (8HQ)-Fe(III) (1: 1,...

A helix-loop-helix gene orchestrates male fate in common carp

Fish show exceptional diversity in sex-determination mechanisms, making them a powerful system for studying how these pathways evolve. However, no definitive master sex-determining gene has yet been identified in Cyprinidae, a widely distributed and species-rich fish family. Here...

Engineered nickel foam dual-function electrode optimised electron transfer and biohydrogen evolution in single chambers microbial electrolysis cells

The widespread deployment of microbial electrolysis cells (MECs) for sustainable H 2 production is critically hindered by the reliance on costly platinum-based electrodes. Herein, we develop a ferric oxyhydroxide-intercalated cobalt phosphide composite supported on nickel foam (F...

Carex ensiformis (C. subg. Siderosticta), a new species from southern China based on morphological and molecular evidence

BACKGROUND: Carex subg. Siderosticta is one of the six subgenera recognized in the recently revised infrageneric classification of Carex based on phylogenetic studies. It represents the earliest-diverging lineage within Carex and it is sister to all remaining species in the genus...

A novel energy evolution-based method for brittleness evaluation of shale considering the deformation and failure process

Accurate evaluation of shale brittleness is critical for optimizing hydraulic fracturing design and predicting well productivity in shale gas development. Current brittleness indices often fail to comprehensively characterize rock brittleness throughout the deformation and failur...

An Agent Framework for Land Resource Monitoring and Analysis

This paper proposes an agent framework for land resource monitoring and analysis. The framework organizes and encapsulates domain knowledge and operational workflows into standardized skill units, enabling the agent to perform task planning, execution, and reflection under skill-...

LLMDPA: pre-execution privacy auditing of DP-SGD via evidence-constrained semantic analysis

Abstract Privacy auditing has emerged as a critical component for safeguarding data privacy in machine learning models. Existing empirical auditing methods heavily rely on model runtime states or post-deployment interfaces, resulting in substantial time costs and limited source-l...