Chinese Academy of Sciences

Association of genetic risk, lifestyle, and their interaction with MRI-based brain aging

Individual brain aging is shaped by both genetic and environmental factors, yet their combined influence remains poorly understood. Using multimodal MRI, genomic data, and lifestyle measures from 46,843 participants in the UK Biobank, we developed and validated a multimodal brain...

Navigating resource constraints in the Yellow River Basin: Drivers and coupling dynamics of the Water-Land-Energy-Carbon nexus

Facing critical resource depletion in the Yellow River Basin, this study establishes a unified framework to analyze the coupled interactions of Water, Land, Energy, and Carbon (WLEC). We quantified WLEC resource distribution, assessed the spatiotemporal dynamics of coupling coord...

Asymmetric bloom lengthening drives high-latitude ocean chlorophyll accumulation imbalance

Terrestrial ecosystems maintain a stable time-allocation budget between growth and senescence, but whether this applies to the ocean remains unclear. Using fused satellite LiDAR and ocean-color data (2007–2022), we show that marine phenology is variable and asymmetric. In high la...

Interfacial Water‐Regulated High‐Entropy Intermetallic Catalysts for Selective Ethylene Glycol Upgrading and Self‐Powered Hydrogen Production

ABSTRACT Selective electrochemical upgrading of ethylene glycol (EG) to glycolic acid (GA) coupled with hydrogen evolution provides a promising pathway for chemical‐energy co‐production, yet remains challenged by CO poisoning, excessive C‐C bond cleavage, and uncontrolled oxygena...

Dynamics analysis, experimental validation and attitude control of a complete satellite with clearance joints considering solid lubrication

The attitude stability of high-precision satellites is significantly affected by the coupled effects of flexible appendages and joint clearances under thermal environments. However, the influence of solid lubrication coatings and experimental validation are rarely considered in e...

Stabilization of 3.5-valent vanadium electrolytes via thermodynamic phase-boundary mapping

Despite the potential of vanadium flow batteries (VFBs) for large-scale energy storage, their commercialization is still hindered by the poor thermal stability of VO 2 + in the positive electrolyte. Additives have improved the electrolyte to some extent, yet they are usually intr...

Intensification of near-inertial currents in the Atlantic Ocean over the past two decades

Near-inertial currents (NICs) play a key role in surface material redistribution and ocean mixing, yet their long-term variability remains poorly known. Using in situ current measurements from surface drifters, we provide observational evidence for a pronounced intensification of...

Trajectory-Constrained Feature Transformation Optimization Framework for Stable Tabular Data Reprogramming

Tabular data reprogramming is a cornerstone of Data-Centric AI, which seeks to mathematically reconfigure raw features into more expressive and model-efficient representations. This process has traditionally relied on extensive manual engineering. Further, recent automated featur...

Contrasting climatic controls on bimodal growth of Pinus elliottii plantations between northern and southern subtropical zones

Subtropical plantation forests play a crucial role in the global carbon cycle, yet intensifying global warming may exert profound impact on tree growth and forest carbon uptake. Pinus elliottii Engelm. is a widely planted and representative plantation species in subtropical regio...

Optimized Land–Water Management Expands Afforestation Potential Under Land and Human Water‐Use Constraints

ABSTRACT Afforestation is a low‐cost and high‐potential climate change mitigation strategy, but its feasibility remains highly uncertain because most existing assessments focus primarily on biophysical suitability and land resource constraints, while largely overlooking the criti...

DSCrisk: A dual-view and substructure aware based method for drug-drug interaction risk-level prediction enhanced by contrastive learning

Combination pharmacotherapy remains a fundamental strategy in contemporary clinical practice. However, the concurrent use of multiple drugs substantially increases the risk of harmful drug-drug interaction events (DDIEs). Developing reliable computational methods for DDIE detecti...

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

ABSTRACT Research on genetic variants affecting the gut microbiome and blood metabolites has mainly focused on single nucleotide variants (SNPs), leaving structural variants (SVs) largely unexplored. Here, we analyzed high‐coverage (∼42×) whole‐genome sequencing data from 2002 in...

UBE2K-FBXO11 complex activates Wnt signaling by stabilizing β-catenin through lysine 63-linked polyubiquitination

Abstract Β-catenin is regulated by phosphorylation and lysine (K)48-linked ubiquitination, which target it for proteasomal degradation. While the degradation machinery of β-catenin, including the destruction complex, has been extensively studied, regulators that stabilize β-caten...

Record‐High Birefringence Achieved by Linearly Extended π‑Conjugated Building Blocks in Metal‐Free Sulfate

ABSTRACT The advancement of birefringent materials is critical for next‐generation integrated photonics, yet conventional systems face intrinsic limitations in birefringence magnitude. Sulfate crystals offer a promising platform but have been hindered by their dependence on speci...

A buckling stagnant slab observed inside the mantle transition zone

Subducting lithosphere is a primary driver of plate tectonics. Seismic tomography shows that some slabs are stagnant in the mantle transition zone (MTZ), and it is debated why they do not continue directly across the MTZ base ( d 660). Here we demonstrate by seismic Receiver Func...

An Atomic-Scale Chemical Switch for Oxide Ferroelectricity

Abstract Interfacial chemistry offers new opportunities for designing ferroelectric materials, yet their coupling with intrinsic polarization remains largely unexplored. Here, we synthesize ferroelectric BiFeO3 nanoparticles with {100} facets covered by a Bi2FeO6-x Aurivillius-li...

Persistent Mn 3+ Sites on Reduced MnO Enable Efficient Syngas Conversion

ABSTRACT Mn‐based materials are widely used for syngas conversion, where MnO is generally regarded as the catalytically active phase under reducing conditions. Yet catalysts derived from different Mn oxide precursors often exhibit markedly different performances despite evolving...

Integrated Multimodal Fusion Network and Multispectral Sensing Photoelectrochemical Platform for Sweat Glucose Monitoring

Abstract Sweat glucose detection offers the advantages of being painless, noninvasive, and suitable for continuous monitoring, showing broad application prospects in diabetes management. However, a single sweat glucose detection method cannot meet the requirements of multiscenari...

MesoScreen: A Computational Platform Providing Unified Data for Liquid-Crystal Research

The development of advanced liquid-crystal (LC) materials requires reliable and standardized structure–property data, yet generating such data through molecular simulation remains time-consuming and technically demanding. Here, we present MesoScreen, an online computational platf...

Trajectory-SAM: Object Trajectory-Guided Segmentation for Remote Sensing Videos

The rapid proliferation of high-resolution remote sensing video (RSV) has made object segmentation an increasingly critical yet challenging task. Existing methods face two fundamental limitations in this domain: (1) the intrinsic complexity of RSVs arising from diminutive object...