Central South University

Cross-population genome-wide meta-analysis identifies pancreatic cancer susceptibility loci and etiologic pathways

Abstract Background Pancreatic cancer is a fatal malignancy influenced by genetic, metabolic, and lifestyle factors. We aimed to identify susceptibility loci and clarify associated genes, biological pathways, and potential etiologic factors. Methods We performed a cross-populatio...

Lack of isomorphic embedding from Lorentz function spaces into Lorentz operator ideals

In the present paper, we study the existence of isomorphic embeddings from Lorentz function spaces 𝐿 𝑝 1 , 𝑞 1 into Lorentz ideals 𝒞 𝑝 2 , 𝑞 2 in 𝐵 ⁡ ( 𝐻 ) . In particular, we show that, for 𝑝 , 𝑞 ∈ ( 0 , ∞ ) , the quasi-Banach function space 𝐿 𝑝 , 𝑞 ⁡ ( 0 , 1 ) isomorphically em...

Computationally guided hapten design enables a colloidal gold immunochromatographic assay for rapid citalopram detection in water and dietary supplements

Citalopram, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has emerged as an environmental and food contaminant owing to its extensive consumption and incomplete removal during wastewater treatment, posing potential risks to aquatic ecosystems and human health...

Multi-Constraint Screening-Guided IN718 Addition for Crack Suppression and Improved Mechanical Properties of Laser-Directed Energy-Deposited IN738LC

IN738LC is a γ′-strengthened superalloy for hot-section components up to 900 °C, but its high Al + Ti content makes it susceptible to cracking during laser-directed energy deposition (LDED). Adding IN718 suppresses cracking but degrades the intrinsic γ′ fraction and the calculate...

Flash Femtosecond Laser Heating-Driven High-Entropy Alloy Anchored Graphene for Anti-Icing/Deicing

Abstract High-entropy alloy nanoparticles (HEA-NPs) offer opportunities for multifunctional thermal conversion because of their multielement composition, tunable electronic structures, and metallic transport characteristics. However, their coupled photothermal–electrothermal beha...

Neural–tumor interactions: bidirectional regulatory mechanisms and nervous system-targeted tumor therapeutic strategies

Neural-tumor crosstalk has emerged as a critical frontier in tumor microenvironment research. Central to this field is the dynamic, bidirectional regulatory network between the nervous system and tumor cells that orchestrates malignant progression. This review focuses on tumors a...

Household food insecurity, dietary intake and anaemia among pregnant women in Lilongwe, Malawi: a mixed-methods cross-sectional study with mediation analysis

Anaemia during pregnancy is a public health concern, yet the relationship between household food insecurity, dietary intake and anaemia among pregnant women remains underexplored. This cross-sectional study investigated these associations in 612 second-trimester pregnant women at...

Heterogeneity in cancer: molecular mechanisms and therapeutic strategies

Cancer heterogeneity drives therapeutic failure, resistance, and relapse and encompasses variation across genetic, cellular, tissue, organ, and systemic scales. Existing frameworks define malignant capabilities and tumor–microenvironment interactions but less explicitly address h...

Local Pressure Response and Load Redistribution Characteristics of Bridge Pier Groups Under Debris-Flow Impact

Bridge piers in debris-flow channels are commonly assessed as isolated members, although an upstream pier may modify the loading applied to downstream piers. This study investigated local pressure responses in tandem twin-pier and equilateral triangular three-pier arrangements us...

Estrogen receptor alpha variants differentially influence proliferation and inflammatory responses in in vitro models of lupus inflammation

Abstract Background Systemic lupus erythematosus (SLE) is an autoimmune disease with female predominance that involves multiple factors, including sex chromosomes, sex hormones, and sex hormone receptor isoforms/variants, such as estrogen receptor alpha (ERα). The mechanisms of n...

Higher inter-rater agreement but more low-risk judgments: the influence of rater experience on RoB 2 assessments

It remains unclear whether risk-of-bias judgments made using the revised Cochrane risk-of-bias tool for randomized trials (RoB 2) by less experienced raters, even after standard training, systematically differ from those made by experienced raters. Our study recruited 12 inexperi...

Cerium-Modified Diatom Biosilica for Lithium-Ion Anodes

Abstract Diatom frustules offer hierarchically porous biosilica templates for sustainable electrode design; however, their low electrical conductivity and limited electrochemically accessible sites constrain lithium-storage performance. In this study, a two-stage cultivation stra...

CLRFI: A multimodal tracking via contrast learning and region feature interaction

RGB-Thermal (RGB-T) target tracking algorithms aim to achieve robust all-weather tracking by leveraging the complementary properties of multiple modalities. Previous methods often fuse RGB and TIR search area features directly, which can introduce redundant background noise and l...

TRACE-FND: A Constrained Evidence-Agent Workflow with Trainable Graph Adjudication for Multimodal Fake-News Detection

Multimodal misinformation often preserves individually plausible text and images while manipulating their relation, provenance, timing, or omitted context. Existing detectors mainly learn fused correlations or verify normalized claims, leaving temporal validity, source reliabilit...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

SIGMA-AD: spatio-temporal integrated graph Mamba architecture for multivariate time-series anomaly detection

Abstract Unsupervised multivariate time-series anomaly detection seeks to detect rare abnormal events in correlated sensor streams when dense anomaly labels are unavailable. Although Transformer-based methods have strengthened long-range representation learning, many still depend...

Vacuum‐Induced Surface Reconstruction of Mn–Ce Oxides for Low‐Temperature Coupled Redox Catalysis

ABSTRACT Low‐temperature redox catalysis over mixed oxides is typically optimized by tuning bulk composition, yet the decisive chemistry occurs at the surface and subsurface interface. Here, we show that this interface can be deliberately reconstructed to enhance Mn–Ce oxide cata...

Climate change exposure and firm value in China: evidence consistent with a discount-rate interpretation

This paper examines the relationship between firm-level climate change exposure and firm value in China. Using A-share listed firms from 2002 to 2020 and a disclosure-based measure of perceived climate change exposure, we find a significant negative association between climate ch...

Consensus Control for Multi‐Agent Systems With Input and Position Constraints

ABSTRACT This paper aims to achieve consensus for multi‐agent systems subject to convex position constraints and nonconvex input constraints. The main challenge arises from the coupling between position and input constraints, where the control input needs to be designed to preser...

Revealing drying-induced crack networks and hydrological pathways in loess using image recognition and continuous X-ray CT

In semi-arid loess landscapes, desiccation cracks significantly affect evaporation, rainfall infiltration, preferential flow, and shallow slope instability. However, existing research largely focuses on crack morphology, lacking insight into continuous three-dimensional crack evo...