Central South University

Expression of LDHA, Pan-Kla Level and H3K18la associates with clinical progression of laryngeal squamous cell carcinoma

Laryngeal squamous cell carcinoma (LSCC) represents one of the major subtypes of head and neck squamous cell carcinoma (HNSC), imposing substantial health burdens and necessitates comprehensive clinical interventions. Lactylation, a newly discovered protein post-translational mod...

Graphene‐Engineered Rear Interfaces Enable Efficient Flexible CZTSSe Solar Cells on Metal Foils

ABSTRACT Flexible kesterite (S,Se) (CZTSSe) solar cells on metal foils are attractive for lightweight and conformable photovoltaic applications, yet their efficiencies remain significantly lower than those of rigid devices due to severe foil‐induced rear‐interface losses during h...

Effectiveness of sexual health interventions in reducing risky sexual behaviors among people living with HIV: a network meta-analysis and systematic review

Abstract Objectives To assess and rank the effectiveness of different sexual health interventions designed to address risky sexual behaviors in PLWH. Methods We systematically searched studies published between Jan. 2010 and Dec. 2024. Randomized controlled trails (RCTs) were inc...

Beyond Tool Rationality: Contextualizing AR Picture Book Acceptance in Parent–Child Shared Reading

Augmented reality (AR) picture books are increasingly used in family learning and parent–child shared reading, but their adoption within families remains underexplored. Based on 439 valid responses from Chinese families, structural equation modeling examined adoption determinants...

BFMambaNet: Boundary-Frequency-Guided Global Semantic Mamba Network for Fine-Grained Camellia oleifera Leaf Disease Segmentation

Camellia oleifera leaf disease segmentation under natural field conditions is important for precision plant protection but remains challenging because lesions often show small target areas, blurred boundaries, uneven illumination, complex backgrounds, and coexisting symptoms. To...

Iron ore pellet firing temperature prediction and abnormality diagnosis based on interpretable machine learning

Accurate control of firing temperature is essential for quality, efficiency and energy consumption in iron ore pellet production. Traditional methods that rely on measured temperatures are limited by sparse measurement points, time lag and signal fluctuations. This study proposes...

Spatially organized regulated cell death-immune coupling in solid tumors: integrating spatial omics with actionable regulated cell death biology

The therapeutic efficacy of immune checkpoint blockade is frequently compromised by the profound spatial heterogeneity of solid tumors, where distinct ecological niches are associated with different patterns of immune engagement. Spatial omics has substantially refined our unders...

A cfDNA fragmentomics-based liquid biopsy assay for early detection of oral cancer

Abstract Background Early detection of oral cancer improves outcomes, but remains limited by the invasiveness and low sensitivity of current screening methods. Methods This study included 342 participants (200 in the training and 142 in the validation cohorts). Plasma cfDNA under...

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

ABSTRACT Epstein‐Barr virus (EBV) is a key oncogenic driver of nasopharyngeal carcinoma (NPC) and is closely associated with cisplatin resistance, but its roles in metabolic reprogramming and chemoresistance remain unclear. This study aimed to investigate the role of EBV in polya...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

Neuroprotection in the early window: a randomized controlled trial of butylphthalide initiation within 3 hours in acute ischemic stroke

Neuroprotective agents have shown promise in preclinical studies but failed to demonstrate efficacy in clinical trials, potentially due to delayed treatment initiation. The optimal therapeutic window for neuroprotection in acute ischemic stroke (AIS) remains undefined. We aimed t...

Unsteady aerodynamics and underbody flow characteristics of high-speed trains with bogie covers at 400 km/h

Although high-speed train (HST) bogie covers effectively reduce aerodynamic drag, they raise safety concerns due to lift-induced oscillations caused by unsteady underbody flow. This study investigates the effects of various bogie covering structures on aerodynamic load pulsations...

Perception and coping with aging among middle-aged women: a qualitative study

Middle-aged women face distinct physiological, psychological, and social challenges during the transition from adulthood to later life. However, their perceptions of aging and the strategies they employ to cope with this process remain insufficiently understood. This qualitative...

Reconciling strong coordination and anion-reinforced solvation structure enables nonflammable electrolytes for potassium-ion batteries

Nonflammable electrolytes are pivotal for improving the safety of potassium-ion batteries. However, their broad adoption has been hindered by the inadequate electrode compatibility of conventional nonflammable electrolytes, which typically result from strong solvation and excessi...

Programming Ion‐Engineered Interphase for Practical Zinc Batteries Through Exogenous Cation‐Anion Synergy Chemistry

ABSTRACT A stable anode‐electrolyte interface is vital for battery cycling. Translating the successful anion‐derived interphase paradigm from Li‐ion to aqueous Zn‐ion batteries (ZIBs) is hindered by narrow electrochemical windows and chaotic interfacial reactions. Here we overcom...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

STING‑regulated Ca²⁺–TGF‑β axis drives airway remodeling and lung function decline in asthma: a multi‑omics mechanistic study

The progressive lung function decline in severe asthma is poorly explained by traditional inflammation‑centered paradigms. Calcium (Ca²⁺) dysregulation and transforming growth factor‑β (TGF‑β) signaling have been implicated, but the molecular link between them and their upstream...

Ferroelectric domain engineering for tunable catalysis

Ferroelectric materials, distinguished by their unique spontaneous and electrically switchable polarization, have emerged as a transformative platform for dynamically regulating various catalytic processes. The rational design and engineering of ferroelectric domain configuration...

Programming Ion‐Engineered Interphase for Practical Zinc Batteries Through Exogenous Cation‐Anion Synergy Chemistry

ABSTRACT A stable anode‐electrolyte interface is vital for battery cycling. Translating the successful anion‐derived interphase paradigm from Li‐ion to aqueous Zn‐ion batteries (ZIBs) is hindered by narrow electrochemical windows and chaotic interfacial reactions. Here we overcom...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...