Central South University

Carbon Black Nanoparticle–PP Fiber Interfacial Engineering for Piezoresistive Self-Sensing Cementitious Nanocomposites

Carbon black (CB) nanoparticles (~20 nm) offer high specific surface area and conductivity for self-sensing cementitious composites, but strong interparticle van der Waals forces drive agglomeration in alkaline pore solutions, limiting sensing reliability. This study introduces a...

Using physiologically based pharmacokinetic modelling to optimize repaglinide and irbesartan dosing in Chinese population with SLCO1B1 polymorphism

Aim The first aim of this study was to develop physiologically based pharmacokinetic (PBPK) models for irbesartan (IRB) and repaglinide (REP) and then apply the REP/IRB PBPK model to describe the drug–drug interaction (DDI) of REP and IRB in the population with SLCO1B1 c.521 T &g...

Integrated population-based evidence, network toxicology, single-cell profiling, and in vitro studies elucidate mechanisms connecting PAHs to stroke

Environmental exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with cardiovascular disease, yet the specific metabolites and cell-type-resolved mechanisms underlying stroke risk remain poorly defined. Here, we applied an integrated multilevel framework comb...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Exercise-containing multimodal prehabilitation on functional outcome of patients with hepatobiliary and pancreatic cancer after surgery: a meta-analysis

Hepatobiliary and pancreatic (HBP) cancers often require complex surgeries that lead to functional decline and poor quality of life (QoL). Exercise-containing multimodal prehabilitation has gained attention as a potential strategy to enhance perioperative outcomes. This meta-anal...

Association between heart rate, metoprolol use, and clinical outcomes in patients with heart failure and chronic obstructive pulmonary disease

Elevated heart rate is a recognized prognostic marker in heart failure (HF), and beta‑blockers are recommended to control heart rate. However, real-world data on discharge heart rate, beta-blocker dosing, and their prognostic associations in patients with concomitant HF and chron...

Lignin migration-driven construction of reed fibers with phosphate-rich interphases and their application in flame-retardant PLA composites

Natural fiber reinforced polylactic acid (NF/PLA) composites are attractive sustainable materials, yet their broader engineering use is limited by weak interphase load transfer and rapid, dripping combustion. A lignin migration driven interphase phosphorylation strategy was propo...

Reversible Oxygen Redoxin High Voltage for Lithium-RichLayered Oxides

Abstract Lithium-rich layered oxides, characterized by Li ions in the transition-metal layers, can significantly increase battery energy density through the introduction of oxygen redox. However, these cathodes often suffer from substantial voltage hysteresis, leading to a consid...

Latent profile analysis of postpartum depression symptoms and its associations with weight stigma and eating behaviors among postpartum women in China

Abstract Background Postpartum depression (PPD) represents a significant maternal health challenge with diverse symptom manifestations. Traditional analytical approaches that treat postpartum women as a homogeneous group may obscure distinct symptom patterns, limiting the develop...

The Structure and Individual Patterns of Emotional and Behavioral Problems in Preschool Children With Autism Spectrum Disorder: Evidence From Network and Cluster Analyses

ABSTRACT This study explored the interactions between emotional and behavioral symptoms in preschool children with autism spectrum disorder (ASD) and identified potential clinical subtypes based on these interrelationships. A total of 1886 preschool children with ASD and 285 age‐...

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K /Akt/ mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Clostridioides difficile infection (CDI) remains a major cause of antibiotic-associated colitis and is characterized by excessive intestinal inflammation, epithelial barrier disruption and impaired mucosal repair. Although sodium butyrate (NaB), a microbiota-derived short-chain f...

PineSegNet: A Deep Learning Method for Fine-Grained Wood-Leaf Segmentation of Masson Pine Point Clouds

Masson pine (Pinus massoniana) is a core timber species in the subtropical regions of Southern China, and the precise monitoring of its growth status and phenotypic characteristics is crucial for forest resource management. To address the segmentation challenges caused by intertw...

Photoacoustic viscoelasticity imaging of thin-cap fibroatheromas: Implications for detecting vulnerable plaques

Viscoelasticity is a key mechanical property for assessing the vulnerability of atherosclerotic plaques. In this Letter, we propose photoacoustic viscoelasticity imaging (PAVEI) to provide morphological information on necrotic-core fibroatheromas together with correlative viscoel...

Competency frameworks for primary care rehabilitation professionals: a scoping review of global practices and implications for developing countries

PURPOSE: Integrated rehabilitation eases chronic mobility dependence, yet competency frameworks struggle to be implemented in resource-limited regions. To map global competency frameworks for primary care rehabilitation professionals and identify specific implications for workfor...

Multifunctional Diluent Enables High‐Voltage and Flame‐Retardant Potassium‐Ion Batteries

ABSTRACT Potassium‐ion batteries (PIBs) emerge as a highly promising candidate system in large‐scale energy storage, owing to their abundant resources, low cost, and potentially high operating voltage. However, the current development of PIBs still faces core bottlenecks such as...

Dehydration-induced CN- defects enable adaptive water regulation in Prussian blue cathodes for high-performance sodium-ion batteries

Abstract Prussian blue analogues have emerged as a promising cathode material owing to their open‑framework structure and high theoretical capacities; however, the presence and dynamic evolution of crystalline water severely constrain their electrochemical performance. Despite ex...

Spectral-habitat analysis and perfusion fingerprinting on contrast-enhanced ultrasound for characterizing tumor perfusion in breast lesions

To develop a short-time Fourier transform (STFT)-based perfusion fingerprinting method combined with spectral-habitat analysis for characterizing pixel-wise perfusion heterogeneity on contrast-enhanced ultrasound (CEUS) and to evaluate its ability to differentiate benign and mali...

Unlocking the Potential of Sparingly Soluble LiNO 3 in Carbonate Electrolytes With Pyridine as a Carrier Cosolvent for 450 Wh Kg −1 High‐Voltage Lithium Metal Batteries

ABSTRACT LiNO 3 is a highly effective electrolyte additive for ether‐based lithium metal batteries, but its extremely poor solubility in carbonate electrolytes has long restricted its application in high‐voltage high‐energy‐density systems. In this study, we develop a pyridine ca...

TNF-α-responsive YAP1 promotes CCL20 expression in colorectal inflammation and cancer

Colitis-associated colorectal cancer (CAC) exemplifies how chronic intestinal inflammation can be converted into sustained epithelial programs and a permissive tumor microenvironment, yet the molecular linkage between inflammatory cytokine cues and chemokine outputs remains incom...

Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer

Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...