Central South University

Complications and revisions of inlay versus onlay design for reverse shoulder arthroplasty: a meta analysis and systematic review

Reverse total shoulder arthroplasty (RTSA) is the standard treatment for rotator cuff tear arthropathy; humeral stems are classified as inlay or onlay, but their comparative risks of complications and revision remain unclear. This systematic review evaluates these outcomes to inf...

MultiRankDTA: A Hybrid Ranking Framework for Robust and Generalizable Drug-Target Affinity Prediction

Abstract Predicting drug-target affinity (DTA) is essential for screening candidate compounds in early-stage drug discovery. However, most existing computational methods formulate DTA prediction as a regression task, leading to an objective mismatch with the practical need to ran...

A multi-dimensional cloud-model-based fuzzy evaluation method for grading nonlinear tunnel large deformation

Abstract Tunnel large deformation is governed by coupled effects of rock mass strength, groundwater, and discontinuity conditions. In practice, blurred grade boundaries and inconsistent indicator definitions often undermine the stability and interpretability of conventional thres...

Non-prescription supportive care interventions for anticancer therapy-induced oral mucositis: protocol for a systematic review and meta-analysis

Abstract Background Oral mucositis (OM) is a common and debilitating complication of anticancer therapies, frequently resulting in pain, nutritional impairment, and potential treatment interruption. While several pharmacologic and device-based interventions have been evaluated, l...

Dynamic modulation of pressure waveforms on slurry penetration in swirl pulsating grouting: performance evaluation and fluid-mechanical mechanisms

Although dynamic pressure grouting mitigates particle clogging, the mechanisms of different pressure waveforms on slurry penetration remain elusive. This study proposes a swirl pulsating pressure grouting (SPPG) technique and establishes a three-dimensional transient two-phase fl...

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

ABSTRACT Aberrant macrophage polarization is one of the key mechanisms underlying chronic obstructive pulmonary disease (COPD), but the underlying processes have not yet been fully elucidated. Lactylation is a novel lactate‐derived post‐translational modification and is relativel...

Timing Matters, Scarring Endures: Parental Marital Status Trajectories and Adolescent Deviant Behaviour

ABSTRACT Under the second demographic transition, the increasing number of children from divorced families may present a range of social challenges. Examining the association between parents' marital trajectories and adolescent deviant behaviour therefore carries significant soci...

Evolution of redox reactivity and mechanical strength of disc-granulated CaMn0.375Ti0.5Fe0.125O3-δ perovskite oxygen carriers during chemical looping combustion

Mechanical strength decay and attrition of oxygen carriers during long-term redox cycling remain key obstacles to the industrialization of chemical looping combustion (CLC). In this work, spherical CaMn 0.375 Ti 0.5 Fe 0.125 O 3-δ perovskite oxygen carrier particles (400–800 μm)...

Disrupted copper homeostasis promotes osteopontin-mediated hepatocyte–stellate cell crosstalk in Wilson disease

Wilson disease is a prototypical disorder of copper metabolism in which hepatic copper overload drives progressive liver injury and fibrosis, yet the molecular mechanisms linking copper accumulation to fibrogenesis remain poorly defined. Here, we identify osteopontin (OPN) as a c...

Collagen-targeted extracellular vesicles from exercised progenitors restore cardiac microcirculation via endothelial AMPK-eNOS-NO axis reactivation

Endothelial dysfunction, driven by impairment of the AMPK-eNOS-NO signaling axis, is a primary defect in diabetic cardiomyopathy (DCM). Extracellular vesicles (EVs) are key mediators of intercellular communication. EVs from exercised conditions possess enhanced bioactivity, but t...

Selective lepidolite–quartz flotation using an environmentally benign collector dodecylbenzenesulfonate isopropanolamine activated by Ca2+

Efficient separation of quartz from low-grade lepidolite ores by flotation remains difficult because the two minerals share similar surface chemistry. In the present work, dodecylbenzenesulfonate isopropanolamine (LAS) was introduced as an environmentally benign collector, with C...

FC-Transformer multiple features fusion for predicting porosity and ILSS in CFRP autoclave processing

Curing pressure plays a critical role in controlling void evolution and improving the manufacturing quality of carbon fiber-reinforced polymer (CFRP) composites during autoclave processing. To gain deeper insight into this pressure–void relationship, a theoretical void-growth equ...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

Artificial Intelligence and Climate Risk Shocks

ABSTRACT Artificial intelligence (AI) has been widely applied across various fields and has demonstrated effectiveness to some extent. However, some scholars have raised concerns about its ethical implications and potential rebound effects, particularly in the context of climate...

Succinate Ameliorates Sepsis‐Associated Acute Kidney Injury by Mediating Inflammation via GPR91

Succinate is a key metabolic intermediate in the tricarboxylic acid (TCA) cycle, which participates in energy metabolism. It accumulates under various pathological conditions and exerts regulatory effects through binding to its specific receptor GPR91. However, its specific funct...

Phase-tailored hydrometallurgy for sustainable valorization of hazardous beryllium-bearing slag

As the primary industrial route for beryllium (Be) production, the magnesiothermic reduction of BeF 2 generates toxic, Be-laden reduction slag, posing severe ecological risks and wasting critical strategic resources. To overcome the prohibitive costs and incomplete recovery of co...

Decoupled probabilistic modeling method for seismic-induced track irregularity on CRTS Ⅲ track-bridge system: Prediction and uncertainty quantification

Seismic-induced track irregularity (STI) is the key factor affecting train safety in high-speed railway bridges. Due to its high-dimensional spatial characteristics, direct prediction of STI may reduce modeling efficiency and prediction accuracy. More importantly, few existing mo...

MHD-Driven natural convection and heat transfer enhancement in hybrid nanofluid-filled sinusoidal porous enclosure

Natural convection in nanofluids is an important process of thermal transport enhancement in the absence of external energy sources, and it makes it extremely preferred in terms of advanced thermal management. In the current research a detailed numerical research is conducted to...

Disentangling the Effects of Organic Spacer Fluorination on Lattice Stability Using an Identical 2D Perovskite Template Framework for Stable Photodetection

Abstract Metal halide perovskite single crystals have emerged as promising optoelectronic materials, yet their long-term stability remains limited by severe ion migration arising from insufficient lattice stabilization. Although fluorination is widely employed to enhance stabilit...

Cross-population genome-wide meta-analysis identifies pancreatic cancer susceptibility loci and etiologic pathways

Abstract Background Pancreatic cancer is a fatal malignancy influenced by genetic, metabolic, and lifestyle factors. We aimed to identify susceptibility loci and clarify associated genes, biological pathways, and potential etiologic factors. Methods We performed a cross-populatio...