Capital Medical University

The morphology of optic disc and the thickness of retinal nerve fiber layer in a population of 9-year-old children in North China

Optic disc morphology and retinal nerve fiber layer (RNFL) thickness have been widely studied in populations with refractive error. This study aims to measure and analyze optic disc parameters and RNFL thickness in different regions of the optic disc in 9-year-old schoolchildren....

Impact of combined medial and lateral bone marrow lesions on clinical outcomes after medial unicompartmental knee arthroplasty

Aims Although the influence of medial bone marrow lesions (BMLs) on outcomes after medial unicompartmental knee arthroplasty (UKA) has been studied, the impact of concomitant lateral compartmental BMLs remains unclear. This study aims to determine whether the lateral BMLs, in add...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Standardized selective clipping for persistent immediate bleeding after cold snare polypectomy of small colorectal polyps: a prospective cohort study

Background and study aims: Delayed bleeding after cold snare polypectomy of 4–9 mm nonpedunculated colorectal polyps is rare, but persistent immediate bleeding is relatively common and lacks a standardized management framework. We prospectively evaluated 30-day outcomes of a stan...

The probability of state transition of five diabetic complications and their influencing factors based on multi-state markov models: evidence from a Chinese cohort study

Diabetes-related complications remain a leading cause of disability and mortality among individuals with diabetes and substantially impair patients’ health-related quality of life. In this study, we employed a multi-state Markov model (MSM) to characterize transition probabilitie...

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

WHO CNS5 mandates integrated histo-molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low- and lower-middle-income countries (LICs/LMICs), limiting implementation of molecularly in...

Balancing privacy and performance: the impact of facial defacing on AI in medical imaging

Background Recent NIH Data Management and Sharing (DMS) policy updates and NIH controlled-access data security requirements have increased attention to facial anonymization and controlled-access handling of shared head imaging data. This is particularly relevant for datasets subm...

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Abstract Ischemic stroke (IS) is one of the primary causes of global mortality and permanent neurological disability, and its clinical treatment is severely constrained by the intricate ischemic pathological cascade and the impermeable blood‐brain barrier (BBB). Cerebral ischemia...

Efficacy and Safety Analysis of Single‐Port Robotic Assisted Cholecystectomy Using a Novel Surgical Platform: A Bicentre, Single‐Arm, Prospective Phase II Clinical Study

ABSTRACT Background Single‐port robotic cholecystectomy offers minimally invasive benefits. This trial evaluated the feasibility and safety of a novel system, MicroPort SA‐1000. Methods In this dual centre, single‐arm, prospective study, eligible patients underwent single‐port ro...

Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study

Abstract Background Plasma 25-hydroxyvitamin D [25(OH)D] deficiency and elevated homocysteine (Hcy) levels are both well-established risk factors for cardiovascular disease (CVD). However, the relationship between 25(OH)D and Hcy remains unclear. To explore the association betwee...

Data Security and Data Governance: From Siloed Implementation to Integrated Assurance

Abstract The current approach to managing medical data separates security and governance into two distinct domains. This commentary argues that data security is a prerequisite for unlocking the value of data, and that data governance can enhance data quality and increase its valu...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Association of Statin Use With Short- and Long-Term Mortality in Critically Ill Patients With Aortic Stenosis: A Retrospective Cohort Study

Background Statins have not been shown to modify valvular disease progression in relatively stable aortic stenosis populations, but their prognostic relevance during critical illness remains unclear. Methods We conducted a retrospective cohort study using the MIMIC-IV database. A...

Beyond Carbapenemases: Chromosomal Resistance Mechanisms and Carbapenemase Type Determine Susceptibility to Novel β-Lactam/β-Lactamase Inhibitor Combinations and Cefiderocol in Carbapenem-Resistant Pseudomonas aeruginosa from China

Background: β-lactam/β-lactamase inhibitor combinations (BL/BLIs) and siderophore cephalosporin serve as critical polymyxin alternatives for carbapenem-resistant Pseudomonas aeruginosa (CRPA). However, systematic multicenter clinical data from China and the resistance mechanisms...

Development, validation, and visualization of a CT-based predictive model for pedicle screw loosening risk after posterior lumbar fusion

This study aimed to develop and validate a visualization-based predictive model for evaluating the risk of pedicle screw loosening (PSL) following posterior lumbar interbody fusion (PLIF) in patients with lumbar degenerative conditions. A total of 466 consecutive patients undergo...

Transcriptional Profiling of Growth Hormone–Secreting Pituitary Adenoma Stem‐Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications

ABSTRACT Growth hormone–secreting pituitary adenoma (GHPA) can cause excessive growth hormone production, which can lead to clinical symptoms such as acromegaly. Tumor stem cells (TSCs) are postulated to play a significant role in the development of GHPA. We performed RNA sequenc...

A Genotype–Phenotype Analysis of Four Chinese Children Carrying Distinct Pathogenic Variants in the CTCF Gene

Objective: The objective of this study was to analyze the clinical phenotypes and genetic variant characteristics of four unrelated Chinese children carrying pathogenic variants in the CTCF gene and to explore the genotype–phenotype heterogeneity of autosomal dominant intellectua...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

Discrimination of the National Early Warning Score versus the 2018 Chinese Emergency Triage Standard for in-hospital mortality in emergency department patients with confirmed high-risk cardiovascular and aortic emergencies: a single-centre retrospective cohort study

Abstract Background The National Early Warning Score (NEWS) is a physiological severity score, whereas the 2018 Chinese Emergency Triage Standard is a categorical triage system used to assign treatment priority. Both use information available at first emergency department (ED) as...