Capital Medical University

Bisphenol F induces intestinal epithelial injury through hsa_circ_0003655-mediated dual-axis disruption of cytoplasmic and organellar calcium homeostasis

As a primary substitute for bisphenol A (BPA), the potential threats of environmental exposure to bisphenol F (BPF) on intestinal health have raised significant concerns. However, the underlying regulatory mechanisms involving circular RNA (circRNA) remain unclear. Utilizing whol...

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

ABSTRACT STING agonists (e.g., cGAMP), which function as immunotherapeutic agents activating the stimulator of interferon genes (STING) pathway, hold promise for treating pediatric solid tumors including neuroblastoma. However, their clinical translation is hindered by limitation...

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

ABSTRACT Ductal carcinoma in situ (DCIS) is a non‐invasive precursor of invasive ductal carcinoma (IDC), yet the biological mechanisms underlying the transition from DCIS to IDC remain incompletely understood. Here, we integrate spatial transcriptomics, single‐cell RNA sequencing...

Neighborhood interaction at age 65 and subsequent initiation and cessation of social participation in Japanese older adults: the NISSIN Project

Whether neighborhood interaction is differently associated with initiation and cessation of social participation in early old age remains unclear. We analyzed 1,688 Japanese adults surveyed at ages 65 and 70. Initiation and cessation were examined separately using modified Poisso...

circRNADisease v3.0: an updated resource for high-quality, experimentally supported circRNA-disease associations.

Systematic integration of circular RNA (circRNA)-disease associations is essential for elucidating the roles of circRNAs in disease pathogenesis and evaluating their potential as biomarkers and therapeutic targets. circRNADisease was established as a manually curated database of...

Urine metabolomics reveals key pathways supporting neuronal regeneration and consciousness recovery in disorders of consciousness

Disorders of consciousness (DoC) are debilitating conditions resulting from severe brain injury, requiring not only structural preservation but also active neuronal regeneration for recovery. These regenerative processes are metabolically demanding and can be tracked through syst...

Early unilateral VZV-associated acute retinal necrosis misdiagnosed as iridocyclitis: a case report

Abstract Purpose To report a case of early unilateral VZV-associated acute retinal necrosis (ARN) which was initially misdiagnosed as iridocyclitis and progressed to retinal detachment. Case presentation A 41-year-old female patient presented with two weeks of blurry vision in th...

Development and validation of a machine learning model integrating clinical and structural brain morphometric features for predicting postherpetic neuralgia: a multicenter cohort study with retrospective development and prospective external validation in China

Postherpetic neuralgia (PHN) is a common and difficult-to-treat complication of herpes zoster (HZ). Early identification of patients at high risk may facilitate risk stratification and individualized intervention. This study aimed to integrate clinical variables with three-dimens...

Optimal exercise dose in adults with chronic low back pain disorders: systematic review with dose-response network meta-analysis

Objective To quantify exercise dose-response relationships and estimate the optimal dose in adults with chronic low back pain disorders (CLBDs). Design Systematic review with random-effects model-based (non-linear) dose-response network meta-analysis. Risk of bias was assessed wi...

First-In-Human PET Imaging of Synaptic Vesicle Glycoprotein 2A with [18F]BIBD-181: Automation, Biodistribution, Dosimetry, and Preliminary Application in Epilepsy

Abstract We report the first-in-human evaluation of [18F]BIBD-181, a novel SV2A tracer designed with a fluoropropyl side chain to enable mild, automated radiosynthesis. A fully automated cGMP-compliant production process was developed on a commercial synthesizer, yielding the tra...

Protocol for measuring above-threshold ionization spectra driven by few-cycle laser pulses in frustrated tunneling ionization regime

Above-threshold ionization (ATI) spectra in the frustrated tunneling ionization (FTI) regime demonstrate control of bound-state populations via the carrier-envelope phase (CEP). Here, we present a protocol for acquiring ATI spectra from argon gas driven by few-cycle laser pulses....

Beyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer’s disease

Alzheimer’s disease is widely conceptualized as a biological continuum initiated by amyloid-β (Aβ) accumulation, followed by tau aggregation and neurodegeneration. Although the ATN framework is commonly used to define disease stages, its static biomarker categories may not fully...

Dynamic urinary proteomic signatures reveal key molecular pathways and biomarkers in pediatric obstructive sleep apnea

This study aimed to determine whether paired pre-sleep and morning urinary proteomic profiling, expressed as the morning-to-bedtime protein ratio, can identify severity-associated molecular signatures and candidate biomarkers in pediatric obstructive sleep apnea (OSA). A total of...

A computational framework for 3D statistical shape modeling of adult Chinese, Indian, and Malay craniofacial structures from CT imaging

Background and objective Three-dimensional statistical shape modeling provides a computational method to quantify anatomical variation from medical imaging. This study aimed to construct statistical shape models of adult Asian craniofacial structures using computed tomography dat...

Osteoclastogenesis with FN1-associated cell differentiation, immune communication, and ECM remodeling in male SAMP6 mice

Early diagnosis and precise treatment of senile osteoporosis remain challenging. Herein, we apply a multi-omics strategy, integrating scRNA-seq and proteomics in the male 5-month-old senescence-accelerated mouse prone 6 (SAMP6) spontaneous aging model, to study early bone loss. T...

The enhanced importance of CD4+ T cell based monitoring of microbial flora in patients with HIV

Individuals infected with human immunodeficiency virus (HIV) frequently display diminished CD4 + T Cell levels, heightening susceptibility to diverse infections and imposing substantial burdens alongside life-threatening risks. This study aimed to compare lung microbial communiti...

Effect of thoracic paravertebral block with liposomal bupivacaine on quality of recovery after video-assisted thoracic surgery: a randomized controlled trial

Abstract Background The effect of thoracic paravertebral block with liposomal bupivacaine on recovery after video-assisted thoracic surgery remains uncertain. Methods This single-centre, double-blind, randomized controlled trial enrolled ninety adults aged 18 to 65 years who were...

APEX1 deficiency impairs oocytes quality by disrupting mitophagy and activating ferroptosis in diminished ovarian reserve

Diminished ovarian reserve (DOR) is pathological condition characterized by reduced oocyte quantity and quality. Due to the complex etiology and limited therapeutic options, clarifying the underlying molecular mechanisms is critical. Oxidative stress has emerged as a pivotal cont...

Triglyceride–glucose body roundness index and risks of incident cardiovascular disease and cardiometabolic multimorbidity: evidence from prospective cohorts in China and England

Cardiovascular disease (CVD) and cardiometabolic multimorbidity (CMM) impose substantial health burdens. The triglyceride–glucose body roundness index (TyG-BRI) integrates metabolic dysfunction reflected by TyG with body-shape information reflected by BRI, but its associations wi...

Brentuximab vedotin combined with risk-adapted chemoimmunotherapy for Hodgkin’s lymphoma in Chinese children: a single-center, nonrandomized controlled study

Classic Hodgkin lymphoma (cHL) has high curability following chemotherapy combined with radiation treatments, but an excess of short-term and long-term treatment-related morbidities remain a concern. The challenge associated with cHL treatment lie in significantly reducing the lo...