Capital Medical University

FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors

Fibroblast growth factor receptor 3 ( FGFR3 ) is one of the most frequently altered genes in bladder cancer, primarily through activating mutations that drive oncogenesis and are enriched in luminal tumors. However, the underlying gene regulatory network (GRN) remains poorly char...

Brain rare metastatic tumors: a clinicopathological analysis of 14 cases

As one of the most common types of malignant brain tumors, brain metastases are associated with poor clinical outcomes. Lung cancer, breast cancer, colorectal cancer, and renal cell carcinoma are the most frequent primary tumors causing brain metastases. This study explores the c...

Factors associated with venous thromboembolism in ICU patients with sepsis: A retrospective analysis using the MIMIC-IV database

This study used the MIMIC-IV v3.1 database to examine factors associated with venous thromboembolism (VTE) in adult ICU patients with sepsis, excluding those with prior VTE or ICU stays under 48 h. Among 14,784 eligible patients, 1,038 (7.0%) developed VTE during their ICU stay....