Capital Medical University

Long-term clinical and radiographic outcomes of interlaminar coflex dynamic stabilization versus posterior lumbar interbody fusion for lumbar spinal stenosis: a comparative study with minimum 15-year follow-up

This study aimed to evaluate the clinical and radiographic outcomes of inter-laminar Coflex dynamic stabilization compared with posterior lumbar interbody fusion (PLIF) for the treatment of lumbar spinal stenosis (LSS) over a long-term follow-up period exceeding 15 years. A retro...

Discrimination of the National Early Warning Score versus the 2018 Chinese Emergency Triage Standard for in-hospital mortality in emergency department patients with confirmed high-risk cardiovascular and aortic emergencies: a single-centre retrospective cohort study

Abstract Background The National Early Warning Score (NEWS) is a physiological severity score, whereas the 2018 Chinese Emergency Triage Standard is a categorical triage system used to assign treatment priority. Both use information available at first emergency department (ED) as...

Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications

Small extracellular vesicles (sEVs) are functional carriers of biomolecules from host cells, making them highly suitable for early disease diagnosis and monitoring disease progression. However, the purification of sEVs from plasma is complicated by the presence of high levels of...

Protocol for the ACTIVE trial: a multicentre, open-label, cluster-randomized controlled trial of a quality improvement programme for older adults with hip fracture in resource-limited hospitals in China

Aims The primary aim of the Action on Hip Fracture Management Quality Improvement (ACTIVE) trial is to evaluate whether a context-tailored quality improvement programme improves health-related quality of life at 120 days after hospital admission, among adults aged 65 years or old...

Spatiotemporal Dynamics and Cellular States of Neuroinflammation in Amyotrophic Lateral Sclerosis: Implications for Stage‑Specific Therapeutics

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex and heterogeneous pathogenesis. Accumulating preclinical and clinical evidence indicates that neuroinflammation is an important modulator of ALS pathophysiology, involving activation of resident cen...

Economic and social modulations of innate decision-making in mice exposed to visual threats

When confronted by predators, animals make innate decisions with rapid reaction times—a trait shaped by natural selection to maximize survival. However, rapid reactions are effective only when grounded in accurate judgments and appropriate choices, which often require cognitive c...

Physiological comparison of high-flow oxygen via endotracheal tube and T-piece strategies during spontaneous breathing trials: a randomized crossover study

<title>Abstract</title> Background The optimal spontaneous breathing trial (SBT) strategy remains uncertain because commonly used approaches involve distinct physiological trade-offs. Pressure support ventilation (PSV) may underestimate the respiratory load after extubation, wher...

Genetic predictive links between oropharyngeal microecology and obstructive sleep apnea syndrome: expanding the perspective of etiology

Background Obstructive sleep apnea syndrome (OSAS), a global public health concern, is linked to oropharyngeal microbiota, but observational studies cannot confirm their causal association.Objective To explore the potential causal relationship between oropharyngeal microecology a...

Gut–Brain–Skin Axis: From Mechanistic Insights to Translational Applications in Neurocosmetics

The gut–brain–skin axis is a proposed integrative framework describing interactions among the gastrointestinal tract, skin, and nervous system through neural, endocrine, immune, and microbial processes. Accumulating evidence has redefined the skin as a sophisticated neuro-immune-...

Body Composition–Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation

Traditional measures such as BMI do not fully capture obesity-related metabolic risks. Here, we examined DXA-derived body composition patterns in children (n = 11,238) using the discriminative dimensionality reduction tree algorithm, which was validated in an independent cohort (...

Uncertainty-inspired open-set model for identifying infantile fundus abnormalities

Accurate and safe identification of infantile fundus abnormalities is critical for large-scale screening, yet remains challenging because of heterogeneous disease presentations and overconfident predictions by conventional artificial intelligence (AI) models. In this study, we ai...

A retrospective comparative study of chronic subdural hematoma in patients with or without decreased level of consciousness

Abstract Background In this retrospective cross-sectional study, we aimed to investigate the effects of preoperative decreased level of consciousness (DOC) on 6-month outcome and the risk factors that compromised the consciousness at admission in patients with chronic subdural he...

CURB-65 score for predicting deep vein thrombosis in severe community-acquired pneumonia: a cohort study

Patients with severe community-acquired pneumonia (SCAP) are at significantly increased risk for venous thromboembolism (VTE). Traditional VTE risk assessment tools like the Caprini and Padua prediction scores are often underutilized in acute care settings due to their complexity...

Impact of sex disparities on laparoscopic adrenalectomy outcomes: a coarsened exact matching study

It is unclear how sex disparities affect surgical outcomes following retroperitoneal laparoscopic adrenalectomy (RLA). Therefore, we studied whether gender could affect RLA outcomes perioperatively. A retrospective study was performed involving consecutive cases underwent unilate...

Preclinical evidence of neuroprotective effects of endocannabinoids and related lipid molecules in ischemic stroke: a systematic review and meta-analysis of animal studies

Background Ischemic stroke is an acute cerebrovascular disorder caused by interruption of cerebral blood supply, frequently resulting in severe neurological deficits. However, effective therapeutic strategies remain limited. Recent studies have demonstrated that endocannabinoids...

Aqueous Humor Proteomics Reveals the Molecular Basis for Differential Treatment Responses in nAMD and pmCNV

Purpose: Choroidal neovascularization (CNV) causes vision loss in neovascular age-related macular degeneration (nAMD) and pathologic myopia-related CNV (pmCNV). Despite shared clinical features, they respond differently to treatment. This study compared aqueous humor (AH) proteom...

Vision-Language Model as a ‘Zero-Shot’ Assistant for Evaluating Condylar Osseous Changes in Cone-beam Computed Tomography

INTRODUCTION AND AIMS: Interpreting condylar osseous changes on CBCT is challenging for general practitioners. This study evaluated the 'zero-shot' diagnostic performance and utility of Vision-Language Models (VLMs) as AI assistants for detecting condylar abnormalities. METHODS:...

Early Changes in Composite Insulin-Resistance Indices After Adjunctive Probiotic Treatment in Olanzapine-Treated Schizophrenia: A Longitudinal Secondary Analysis

Objective Olanzapine is effective for schizophrenia but commonly causes metabolic dysregulation. This study examined whether adjunctive probiotic treatment was associated with short-term changes in composite insulin-resistance-related indices during olanzapine therapy. Methods Th...

Serum brain-derived neurotrophic factor is associated with diabetic complications and glycemic control in type 2 diabetes: an exploratory analysis of the ADNI cohort

To investigate the association between serum brain-derived neurotrophic factor (BDNF) levels and the clinical profile as well as complications in patients with type 2 diabetes mellitus (T2DM). A total of 185 participants were enrolled, including 35 healthy controls, 111 T2DM pati...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...