Capital Medical University

Spinopelvic alignment changes after unilateral total knee arthroplasty associated with functional recovery

Abstract Background The biomechanical interaction between knee pathology and spine–pelvis alignment in advanced knee osteoarthritis (KOA) has received increasing attention. This study evaluated short-term changes in spinopelvic alignment after unilateral total knee arthroplasty (...

EXPRESS: Diagnostic Accuracy of Noninvasive Translesional Pressure Ratio Based on Magnetic Resonance Imaging for Intracranial Atherosclerotic Stenosis: A Validation Study

The anatomic stenosis severity of intracranial atherosclerotic stenosis (ICAS) does not reliably reflect lesion-specific hemodynamic impairment, and invasive pressure-wire assessment is technically challenging in the cerebral circulation. This study aimed to develop and validate...

Severe Legionella pneumophila pneumonia complicated by rhabdomyolysis and myocarditis: a case report

Legionella pneumophila is an important cause of severe community-acquired pneumonia and may be accompanied by extrapulmonary abnormalities. Hyponatremia and hepatic biochemical abnormalities are recognized clinical clues, whereas rhabdomyolysis and myocarditis are uncommon compli...

Development and validation of an interpretable prognostic model for in-hospital GCS-based neurological recovery after intracerebral hemorrhage in young and middle-aged adults: a multicenter retrospective cohort study

Prognostic tools for intracerebral hemorrhage (ICH) are largely derived from older or mixed-age cohorts and rarely incorporate lifestyle factors, limiting their relevance to young and middle-aged adults. We aimed to develop and externally evaluate an interpretable model for unfav...

Adjunctive posterior tibial tendon transfer during supramalleolar osteotomy for varus ankle osteoarthritis: a matched cohort study

The role of adjunctive posterior tibial tendon (PTT) transfer in supramalleolar osteotomy (SMO) for varus ankle osteoarthritis remains unclear. This study aimed to compare clinical and radiographic outcomes between SMO with adjunctive PTT transfer and isolated SMO, with particula...

Survival of patients with advanced non-small cell lung cancer harboring different ROS1 fusion subtypes: a real-world study

Abstract Background c-ros oncogene 1 (ROS1) rearrangement is a rare yet significant genetic abnormality in non-small cell lung cancer. However, real-world treatment data for Non-Small Cell Lung Cancer (NSCLC) patients with different ROS1 fusion subtypes remain limited. Methods Me...

Water hardness and all-cause and cause-specific mortality: evidence from a prospective cohort study

The health implications of domestic water hardness remain controversial, with limited prospective evidence on cause-specific mortality. We investigated associations of calcium carbonate (CaCO 3 ), calcium (Ca), and magnesium (Mg) concentrations with all-cause and cause-specific m...

Left ventricular end-diastolic diameter to body surface area ratio as a continuous risk marker in left ventricular non-compaction with a dilated phenotype: a multicenter cross-sectional study

Dilated cardiomyopathy (DCM) is a risk factor for poor outcomes in patients with left ventricular non-compaction (LVNC). This study aims to identify key factors associated with the DCM phenotype in LVNC and develop a risk stratification model. This multicenter cross-sectional stu...

Developing a health values framework for patients with cardiovascular-kidney-metabolic syndrome: a qualitative exploration through the lens of social determinants of health

Abstract Background Despite global calls for the advancement of patient-centered care, care planning often remains poorly aligned with patients’ lived social contexts and core values. This study aimed to understand what matters most to patients with cardiovascular-kidney-metaboli...

Unveiling the Diagnostic Value and Potential Therapeutic Targets of Phenylalanine Metabolism in Pancreatic Cancer via Integrated Multi‐Omics and Machine Learning

ABSTRACT Pancreatic cancer (PC) presents a significant global health challenge because of its high mortality rate, highlighting the urgent requirement for effective early diagnostic and therapeutic strategies. This study examined the function of phenylalanine metabolism in PC and...

Clinical Value of an LDH–CA125–NLR Panel for Diagnosis, Platinum Resistance, and Prognostic Assessment in Epithelial Ovarian Cancer

(1) Background/Objective: Routine blood tests may provide useful information at different stages of epithelial ovarian cancer (EOC) management. This study evaluated continuous lactate dehydrogenase (LDH), carbohydrate antigen 125 (CA125), and neutrophil-to-lymphocyte ratio (NLR)...

Association Between Brain Natriuretic Peptide and Intradialytic Hypotension in Hemodialysis Patients: A Retrospective Study

Background: Intradialytic hypotension (IDH) is a common complication of hemodialysis (HD) and is associated with an increased risk of poor prognosis. This study investigated the factors associated with IDH in HD patients and explored the value of brain natriuretic peptide (BNP) i...

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

5C psychological antecedents of vaccine hesitancy toward maternal RSV vaccines and infant monoclonal antibodies among pregnant and postpartum women and their partners in China: A multicenter, dyadic survey design, cross-sectional study

We assessed vaccine hesitancy toward two novel respiratory syncytial virus (RSV) immunization strategies, maternal vaccines and infant monoclonal antibodies (mAbs), among 4422 couples across eight Chinese provinces, via a multicenter cross-sectional survey with convenience sampli...

Development and internal validation of a model predicting four year cardiovascular kidney metabolic syndrome stage progression

Abstract To develop a model for predicting cardiovascular-kidney-metabolic (CKM) syndrome stage progression in middle-aged and older Chinese adults and to evaluate the incremental predictive value of routinely available clinical variables beyond baseline CKM stage. This study use...

Analysis of hematologic toxicity profiles following CAR-T cell therapy: a retrospective cohort study

Abstract Background Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of relapsed/refractory (R/R) B-cell malignancies, most notably large B-cell lymphoma. However, hematologic toxicity—recently formalized as immune effector cell-associated hematotoxici...

Extracardiac CKM phenotypes and early cardiorenal-systemic mortality risk after acute myocardial infarction

Abstract Background Acute myocardial infarction (AMI) represents established cardiovascular disease within the cardiovascular-kidney-metabolic (CKM) continuum, yet outcomes after the acute event vary widely. We examined whether extracardiac metabolic, renal, inflammatory, and nut...

Olig2 downregulation mitigates early neurological deficits by modulating mitochondrial dynamics in neonatal hypoxic-ischemic brain injury

OBJECTIVE: Mitochondrial dysfunction and apoptosis are key pathological events in neonatal hypoxic-ischemic brain damage (HIBD). Oligodendrocyte transcription factor 2 (Olig2) is upregulated during the early phase of hypoxic-ischemic brain injury. This study aimed to investigate...

Role of Pulmonary Microbiota Dysbiosis-Mediated Epithelial–Mesenchymal Transition in Silicosis Fibrosis

Abstract Silicosis is a life-threatening occupational disease characterized by irreversible pulmonary fibrosis. While lung microbiota dysbiosis is implicated in its pathogenesis, the molecular mechanisms linking microbial alterations to fibrotic progression remain incompletely un...

Dynamic Echocardiographic Trajectory Phenotypes During Veno‐Arterial Extracorporeal Membrane Oxygenation and Their Association With In‐Hospital Mortality: A Multicenter Cohort Study

BACKGROUND: Current risk stratification for veno-arterial extracorporeal membrane oxygenation relies on static assessments, ignoring dynamic cardiac evolution. We aimed to identify longitudinal echocardiographic trajectory phenotypes and evaluate their association with in-hospita...