Capital Medical University

Association of the C-reactive protein-triglyceride glucose index with incident hypertension across glycemic status: a longitudinal cohort study

The C-reactive protein-triglyceride glucose index (CTI) is a composite indicator that integrates systemic inflammation, lipid metabolism, and glucose metabolism. Previous studies have reported an association between CTI and incident hypertension, but evidence across different gly...

Active commuting and biological aging: Cross-sectional evidence from the UK Biobank

Objective To investigate whether commuting mode is associated with biological aging, including KDM 's Biological Age Acceleration (KDM-BAA), PhenoAge Acceleration (PhenoAA) and leukocyte telomere length (LTL) based on the UK Biobank (UKB). Methods We performed a cross-sectional s...

School-based hygiene intervention to prevent Helicobacter Pylori infection among children (SHIP HOPE): a cluster-randomized controlled trial

Helicobacter pylori ( H. pylori ) is a major cause of gastric cancer and is typically acquired during childhood. Preventing infection in uninfected children is a promising strategy; however, the effectiveness of hygiene-based interventions remains uncertain. This study aimed to d...

Effects of high-frequency rTMS targeting the primary motor cortex on pain, function, and brain network connectivity in patients with chronic nonspecific low back pain: an exploratory fNIRS analysis of a randomized sham-controlled trial

This study evaluated the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on pain and functional outcomes in patients with chronic nonspecific low back pain (NSLBP) and explored intervention-related changes in resting-state brain functional connectivi...

sTREM2 and GFAP mediated the association of cerebrospinal fluid GLP-1R with tau pathology in alzheimer’s disease

Glucagon-like peptide-1 receptor (GLP-1R) is involved in metabolic regulation and has also been implicated in neuroprotection and the modulation of neuroinflammatory processes in the central nervous system. GLP-1R has therefore emerged as a potential therapeutic target for Alzhei...

Proteasome subunit-based biomarker panel for early diagnosis of acute respiratory distress syndrome and therapeutic targeting of PSMB8 in a mouse model

Acute respiratory distress syndrome (ARDS) remains a leading cause of mortality in intensive care units worldwide. Timely diagnosis and targeted treatment are critical for significantly improving patient outcomes. Plasma proteomics from 196 patients with ARDS, 100 non-ARDS pulmon...

From endovascular therapy to perivascular therapy: A new concept and perspective

The cardiovascular system relies on an organ-spanning vascular network not only for transport but also for systemic homeostatic control. Surrounding the vessel wall is a complex perivascular microenvironment, including the vasa vasorum, autonomic and sensory nerves, perivascular...

The safety and efficacy of different anti-tuberculosis regimens containing Lzd for RR/MDR/Pre-XDR-TB patients in China

China remains a high-burden country for rifampicin-resistant tuberculosis. The treatment of drug-resistant tuberculosis is expensive, with many adverse drug reactions and greater difficulty to cure. Searching for appropriate treatment regimens is urgent. A retrospective study was...

Continuous glycemic phenotype derived from latent class mixed models predicts 28-day mortality after traumatic brain injury: a two-cohort study

Abstract Acute stress hyperglycemia is common after traumatic brain injury (TBI) and is associated with adverse outcomes. However, the prognostic value of longitudinal glucose trajectories during the early ICU stay remains poorly characterized, and whether post-TBI glycemic dynam...

The “Five in One” integrated precise prevention and control system for pollen allergic diseases in Northern China: A narrative review with global perspective

Allergic diseases driven by airborne pollen are a growing public health burden in Northern China, where spring tree pollens and summer–autumn weed pollens are major triggers of allergic rhinitis, asthma, conjunctivitis, atopic dermatitis, and anaphylaxis. Internationally, managem...

Etiological characteristics and genotypes of Mycoplasma pneumoniae infection in children in Baoding from 2022 to 2024

ABSTRACT To investigate the epidemiology associated with genetic types and macrolide resistance of Mycoplasma pneumoniae (MP) in children during and post-COVID-19 in Baoding. A retrospective analysis was conducted on 13,534 children and adolescents (≤18 years old) with community-...

Texture similarity network uncover schizophrenia subtypes with unique molecular signatures

Abstract Schizophrenia manifests complex heterogeneity across multiple dimensions, posing major challenges for precise diagnosis and treatment. Developing objective biomarkers to stratify patients into stable subtypes is essential for heterogeneity resolving and precision medicin...

Sleep quality is associated with gut microbiome signatures of hyperuricemia in Chinese elderly adults: a community-based case–control study

Hyperuricemia (HUA) has become a global health issue due to its rapidly increasing prevalence. Growing evidence from population and animal studies suggests that gut microbial dysbiosis and lifestyle changes are involved in serum uric acid metabolism. However, most existing studie...

Application of Shear Wave Elastography in Assessing Peripheral Neuropathy in Parkinson’s Disease

Background/Objectives: Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, and its comorbid peripheral neuropathy (PN) severely worsens patient prognosis. The diagnostic gold standard, nerve electrophysiological examination, has critical limitations, including inv...

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and a...

Cerebellar cortical amyloid deposition biases 18F-Florbetapir PET quantification with whole cerebellum as reference region

To investigate whether cerebellar cortical amyloid-beta (Aβ) deposition biases 18F-Florbetapir Aβ PET quantification when the whole cerebellum (WC) is used as the reference region, and to identify a stable reference region for quantification. Additionally, to establish an optimal...

Multicenter evaluation of Coyote FlashDetect LyocartE multiplex assays for six respiratory pathogens: a comparative analysis with Sansure and Cepheid assays

ABSTRACT Respiratory diseases caused by common respiratory pathogens, such as influenza A/B (Flu A/B), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), respiratory syncytial virus (RSV), adenovirus (ADV), and Mycoplasma pneumoniae (MP), share many of the same symptom...

EXPRESS: Diagnostic Accuracy of Noninvasive Translesional Pressure Ratio Based on Magnetic Resonance Imaging for Intracranial Atherosclerotic Stenosis: A Validation Study

The anatomic stenosis severity of intracranial atherosclerotic stenosis (ICAS) does not reliably reflect lesion-specific hemodynamic impairment, and invasive pressure-wire assessment is technically challenging in the cerebral circulation. This study aimed to develop and validate...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Early Risk Stratification and Time-to-Cure Analysis in Patients with Residual Hemifacial Spasm After Microvascular Decompression

Background/Objectives: Microvascular decompression (MVD) is an effective treatment for hemifacial spasm (HFS), but some patients have residual spasms after surgery. Some later achieve delayed cure, whereas others have persistent HFS, making reoperation planning difficult. This st...