Capital Medical University

Retinal Microvascular Abnormalities, White Matter Injury, and Cognitive Impairment in Carotid Stenosis or Occlusion

Background Severe carotid artery stenosis or occlusion (CASO) is associated with white matter injury and cognitive impairment, but markers of accompanying microvascular dysfunction remain incompletely characterized. We investigated the relationships among retinal microvascular ab...

Development and validation of the Beliefs in Social Anxiety Scale (BIAS) for Chinese socially anxious adults and adolescents

BACKGROUND: Maladaptive social beliefs play a pivotal role in the development and maintenance of social anxiety; however, existing measures have limited cultural adaptability for Chinese populations. Therefore, this study developed and validated the Beliefs in Social Anxiety Scal...

Factors associated with primary care workers’ willingness for mental health services

Residents' mental health problems have become increasingly prevalent in recent years, accompanied by younger onset ages and rising incidence.Psychological distress among the elderly, emotional disorders in adolescents and mental stress in patients with chronic diseases 1 have gra...

Screening patterns for cognitive dysfunction and influencing factors analysis for referral and training rate: Experience from a health management center

Background Implementing cognition health screening, risk assessment, and early intervention for cognitive impairment-related diseases among appropriate demographics holds significant importance in China. Objective This study aims to present a cognition health management model and...

Elevated Blood Pressure Is Causally Associated With Larger Subcortical Gray Matter Structure Through Perivascular Clearance Routes

ABSTRACT Background This study aimed to investigate the association between elevated blood pressure (BP) and subcortical gray matter structures, and to elucidate the causality and underlying mechanisms. Methods This study enrolled 1012 participants from a multicenter, population‐...

Insomnia is associated with altered arachidonic acid–induced platelet aggregation and lower cholesterol independent of age in aspirin-treated unstable angina: a machine learning analysis

BACKGROUND: In aspirin-treated unstable angina (UA), heterogeneity in on-treatment arachidonic acid (AA)-induced platelet aggregation and cholesterol reduction contributes to residual ischemic risk. Insomnia is prevalent in coronary disease, yet its association with specific aspi...

PET-based evaluation of short-term amyloid-β clearance and predictive factors in real-world Alzheimer's disease patients treated with lecanemab

Background Alzheimer's disease (AD) is a common progressive neurodegenerative disorder. Lecanemab, an anti-amyloid-β (Aβ) monoclonal antibody, is approved for AD treatment, but real-world efficacy and optimal PET application strategies remain incompletely defined. Objective To in...

Accelerometer-measured moderate-to-vigorous physical activity patterns and mortality among individuals with venous thromboembolism: a prospective cohort study from the UK Biobank

Although the “weekend warrior” activity pattern has been associated with lower mortality in the general population, whether it is associated with long-term outcomes after venous thromboembolism (VTE) remains unclear. In this prospective analysis, we examined the association betwe...

Macrophage pyroptosis drives luminal senescence and club-cell reprogramming in 5α-reductase inhibitor-treated prostatic hyperplasia

Abstract Benign prostatic hyperplasia (BPH) is a common age-associated disease whose prevalence rises sharply with advancing age. Therapeutic responses to 5α-reductase inhibitors (5-ARIs) in BPH are heterogeneous and may ultimately culminate in the need for surgery; however, the...

Association of inflammatory biomarkers and pericoronary fat attenuation index with coronary functional ischemia in patients with metabolic dysfunction-associated fatty liver disease

Patients with metabolic dysfunction-associated fatty liver disease (MAFLD) and coronary heart disease (CHD) exhibit systemic and coronary inflammation. However, the value of integrating systemic inflammatory biomarkers and the pericoronary fat attenuation index (FAI) for identify...

Three-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma: a multicentre study

Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with ext...

Global epidemiological and genetic burden of rare neurological diseases in children

We assessed the global burden of rare childhood neurological diseases from 1990 to 2021 and projected trends to 2050 using Global Burden of Disease data, alongside an analysis of the genetic burden from ClinVar. Four neurological conditions were classified as rare childhood neuro...

Pathophysiological mechanisms and therapeutic strategies of hepatic ischemia–reperfusion injury

Abstract Hepatic ischemia–reperfusion injury commonly occurs in conditions such as trauma, shock, hepatectomy, and liver transplantation. In the absence of timely intervention, severe cases may progress to liver failure, significantly affecting patient prognosis and surgical outc...

Timing of transurethral laser enucleation of the prostate after transperineal prostate biopsy: a multicenter cohort study

The optimal timing of transurethral laser enucleation of the prostate after transperineal prostate biopsy (TPB) remains uncertain. This study evaluated whether the interval between TPB and subsequent transurethral laser enucleation influences perioperative outcomes and postoperat...

Literature review of myasthenia gravis complicated by myocardial damage

Background: Myasthenia gravis (MG) is a chronic autoimmune disorder predominantly driven by pathogenic autoantibodies directed against postsynaptic acetylcholine receptors, impairing neuromuscular transmission. Although cardiovascular complications remain relatively uncommon amon...

Association of depressive symptoms with retinal layer thickness: insights from the population-based Beijing eye study 2011

The aim of this study is to investigate the association between depressive symptoms and retinal layer thickness in a population-based adult Chinese cohort. This population-based, cross-sectional study included 2127 eyes of 2127 participants of Beijing Eye Study 2011, free of any...

Outpatient versus telephone follow-up and blood pressure control in China: a longitudinal study in primary care

As the population ages, long-term standardized management of hypertension has become a critical task for primary healthcare systems. Telephone follow-up is widely used as a supplementary approach to outpatient care; however, its long-term effectiveness in real-world settings rema...

Self-reported outcomes and associated factors among patients with cancer completing Mongolian mind-body interaction therapy: a cross-sectional study

Introduction Patients with malignant tumors face physical illness and psychological distress. Mongolian mind-body interaction therapy (MMBIT) is a group-based intervention combining modern psychology with traditional Mongolian medicine. As a complementary oncology approach, MMBIT...

Synergistic effects of cerebrovascular reactivity and gray matter volume on executive function in aging

Background Age-related impairments in cerebrovascular reactivity (CVR) and gray matter volume (GMV) both contribute to cognitive decline, yet their regional interplay and joint impact on cognition remain unclear. Objective To investigate how CVR and GMV are coupled and interact r...

Diagnostic efficiency of serum-based fourier transform infrared spectroscopy for brain tumors: a systematic review and meta-analysis

Fourier transform infrared (FTIR) spectroscopy has been widely explored as a non-invasive diagnostic tool in oncology. However, the overall diagnostic performance of serum-based FTIR spectroscopy for brain tumor detection has not been systematically evaluated. This meta-analysis...