Capital Medical University

Changes in frailty and incident circadian syndrome in middle-aged and older adults: a nationwide prospective cohort study

Circadian syndrome (CircS) is more predictive than metabolic syndrome (MetS). However, few studies have examined its risk factor. This study aims to investigate whether the static state or dynamic change of frailty is correlated with incident CircS in Chinese adults. Data were ob...

Stapokibart efficacy by asthma status in chronic rhinosinusitis with nasal polyps: a post hoc analysis of the CROWNS-2 trial

Background: Asthma is a common comorbidity in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Stapokibart, a novel anti-interleukin-4 receptor alpha monoclonal antibody, demonstrated efficacy and safety in patients with CRSwNP in a phase 3 trial (NCT05436275). Ob...

Multisite Extraocular Dryness is Associated with Symptomatic Dry Eye and Tear-Film Instability Among Adults Without Severe Meibomian Gland Loss

PURPOSE: To evaluate whether a greater number of self-reported extraocular dryness sites is associated with Ocular Surface Disease Index (OSDI)-defined symptomatic dry eye and non-invasive tear break-up time (NIBUT)-defined tear-film instability among community-dwelling adults wi...

Development of an explainable machine learning model for predicting six-month consciousness recovery in patients with prolonged disorders of consciousness

With advances in emergency care systems, the number of patients with prolonged disorders of consciousness (pDoC) has markedly increased. To optimize the allocation of healthcare resources and mitigate risks, the early and accurate identification of recovery potential in pDoC is e...

WHR and adverse health outcomes: a prospective study on cancer incidence, all-cause and cancer-specific mortality

Obesity is a significant global public health issue, traditionally linked to adverse health outcomes. However, the “obesity paradox” suggests that in certain populations, obesity may be associated with better prognosis. This study investigates the relationship between waist-to-hi...

Interdependencies among factors related to participation in smart home-based elderly care platforms in China: an exploratory social network analysis

Despite increasing policy investment in smart home-based elderly care platforms, participation among older adults and care institutions remains limited. Existing studies have primarily examined participation-related factors from either the demand or supply side, but have paid lim...

Association of sarcopenia and longitudinal changes in sarcopenia status with all-cause mortality in individuals with cardiovascular-kidney-metabolic syndrome

We investigated the associations of sarcopenia, handgrip strength (HGS), appendicular skeletal muscle mass index (ASMI), and longitudinal changes in sarcopenia status with all-cause mortality among middle-aged and older adults aged ≥ 50 years with cardiovascular-kidney-metabolic...

Assessing quality in minimally invasive D2 lymphadenectomy: from technical difficulty to AI-enabled audit

Minimally invasive D2 lymphadenectomy for gastric cancer is technically demanding, and its quality varies across patients, surgeons, platforms, and institutions. Conventional endpoints, including lymph node yield, margin status, operative time, blood loss, postoperative morbidity...

Depressive Symptoms Trajectories Across the Transition to Cardiovascular Disease in Middle-Aged and Older Adults: A Multicohort Study

Abstract Aims The long-term depressive symptoms trajectories across the transition to diagnosed cardiovascular disease (CVD) remain poorly characterized. We aimed to investigate trajectories of depressive symptoms before and after incident CVD in multinational aging populations....

Does Age Moderate Metabolic and Hormonal Adaptations to Resistance Training in Overweight Female Athletes? A Study Protocol for a Prospective, Age-Stratified Randomized Controlled Trial

Background: A recently completed 12-week randomized controlled trial (RCT) of resistance training (RT) in overweight female university athletes in China found, in exploratory regression analysis, that age — not baseline BMI — significantly predicted the magnitude of insulin-sensi...

Does Age Moderate Metabolic and Hormonal Adaptations to Resistance Training in Overweight Female Athletes? A Study Protocol for a Prospective, Age-Stratified Randomized Controlled Trial

Background: A recently completed 12-week randomized controlled trial (RCT) of resistance training (RT) in overweight female university athletes in China found, in exploratory regression analysis, that age — not baseline BMI — significantly predicted the magnitude of insulin-sensi...

EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy

Purpose EIF1, an RNA-binding protein implicated in multiple diseases, remains poorly characterized in diabetic retinopathy (DR). This study therefore investigated EIF1 expression and function in an in vitro model of DR pathogenesis. Methods Human retinal pigment epithelial cells...

Rickettsia japonica strain YC21 from a fatal human case in China: comparative genomics and experimental characterization of infection phenotypes

Rickettsia japonica causes Japanese spotted fever (JSF), an emerging severe tick-borne disease in East Asia. We recently isolated strain YC21 from the first laboratory-confirmed fatal JSF case in China. This study aimed to characterize the genomic features and infection phenotype...

Comparative evaluation of selective media and key factors affecting isolation of V. cholerae and V. parahaemolyticus

Abstract Thiosulfate citrate bile salts sucrose (TCBS) agar is a widely used selective medium for the presumptive isolation of Vibrio spp, playing an essential role in food safety and public health surveillance. However, variations among commercial formulations may significantly...

Nintedanib in the prevention of radiation-induced lung injury in patients with unresectable stage II-III NSCLC: A protocol for a randomized, multicenter, control group study

Background Radiation-induced lung injury (RILI) is a common and dose-limiting complication in patients with non-small cell lung cancer (NSCLC) receiving radiotherapy, especially in combination with chemotherapy and/or immunotherapy. RILI encompasses acute radiation pneumonitis (R...

Ticagrelor-Aspirin With Thrombolysis by Infarct Patterns in Moderate Ischemic Stroke: TAPIS Subgroup Analysis

BACKGROUND: Whether diffusion‑weighted imaging infarction patterns influence the efficacy and safety of early oral ticagrelor‑aspirin with intravenous thrombolysis in moderate acute ischemic stroke is uncertain. We assessed treatment effects by infarction pattern in this thrombol...

Terahertz-based prognostic framework for glioma: from spectral features to patient-level prognostic assessment

In glioma, accurate prediction of recurrence and survival is essential for clinical decision-making and individualized management. However, current prognostic tools do not fully capture outcome heterogeneity, and convenient approaches for early postoperative prognostic evaluation...

Handgrip strength and/or Timed Up and Go Test are associated with functional independence and psychological well-being in older women

Abstract Background Handgrip strength (HGS) and Timed Up and Go (TUG) tests are established measures of physical capacity and widely utilized in geriatric assessments. We aimed to assess their independent and combined association with activity of daily living (ADL) and psychologi...

Targeting p38α promotes Parkin-mediated mitophagy to attenuate severe acute pancreatitis via suppressing the mtDNA/cGAS-STING signaling pathway

Abstract Severe acute pancreatitis (SAP) is a life-threatening acute inflammatory disorder characterized by systemic inflammation and high mortality, for which specific targeted therapeutic strategies are still severely lacking in clinical practice. Mitochondrial dysfunction and...

A fully automated deep learning pipeline system for carotid plaque segmentation and vulnerability classification on multi-contrast MRI: a multicenter study

Abstract Background Carotid vulnerable plaque rupture is a major cause of ischemic stroke. However, accurate identification of high-risk plaques using medical images heavily relies on radiologists’ expertise. This study aimed to develop an artificial intelligence (AI) system for...