Capital Medical University

Expert Consensus on Robot-Assisted Vascularized Bone Grafting for the Treatment of Early-Stage Osteonecrosis of the Femoral Head

Osteonecrosis of the femoral head (ONFH) remains a progressive clinical challenge that predominantly affects young and active adults between 20 and 50 years of age. Without timely and effective surgical intervention, natural disease progression leads to structural subchondral fra...

Bone-targeting engineered exosomes delivering teriparatide mRNA for the treatment of osteoporosis

Introduction Teriparatide (TPTD) is an established osteoanabolic agent for the treatment of osteoporosis; however, its short circulating half-life necessitates repeated administration, while limited skeletal selectivity may reduce delivery efficiency. To address these limitations...

Association and potential mechanisms between maternal amniotic fluid microbiota heterogeneity and fetal complex congenital heart disease

Numerous studies have found that dysbiosis of the microbiota is associated with cardiovascular diseases in humans and shows certain links to congenital heart disease (CHD) in children. However, direct evidence regarding whether maternal gut microbiota is related to fetal heart de...

QHHP Ameliorates MASH Through Modulation of a Cyp4a32–PPARγ–CD36‐Associated Lipotoxic Axis

Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive stage of metabolic dysfunction-associated fatty liver disease, for which effective pharmacological therapies remain limited. Qinggan Huatan Huoxue Prescription (QHHP) has been used clinically in the manageme...

Endoscopic Endonasal Approach to the Medial Aspect of the Temporomandibular Joint Region

ABSTRACT Background The temporomandibular joint (TMJ) region is the most superolateral aspect of exposure via an endonasal corridor, while studies regarding the endonasal approach to this specific region are lacking. This study aimed to provide a detailed step‐by‐step surgical te...

External validation and comparative performance of four risk scores for acute kidney injury in critically ill adults

Background Several parsimonious scores predict acute kidney injury (AKI), but their comparative performance in critically ill adults is uncertain. We hypothesized that the ICU-derived UCSD-Mayo score would show higher discrimination than three scores developed in broader acute-ca...

Commutability Assessment of Materials for Serum Copper Measurement Using the IFCC Difference-in-Bias and the CLSI EP30 Approaches

Background: Evidence on the commutability of material for serum copper when assessing multiple material categories and assay pairs remains limited. Methods: We evaluated 21 reference materials for serum copper across four routine colorimetric systems and an inductively coupled pl...

Sex-Specific Plasma Proteomic Alterations Underpin Distinct COVID-19 Progression and Post-COVID-19 Condition

Abstract Sex differences in COVID-19 and its sequelae remain poorly understood, which hinders targeted therapies. We performed plasma proteomic analyses of 69 hospitalized patients with COVID-19 and 30 healthy controls from a prospective Chinese cohort. The UK Biobank and Mount S...

Dynamic negative symptom networks following personalized iTBS in schizophrenia

Background Negative symptoms are clinically heterogeneous and may be represented as interacting symptom domains. Whether personalized intermittent theta-burst stimulation (iTBS) is associated with changes in contemporaneous or temporal associations among negative-symptom domains...

Protection of beta-blocker and 5-hydroxytryptamine 1A receptor agonist on myocardial ischemia injury in rats by regulating the NLRP3/Caspase-1/GSDMD pathway

Objective To explore the effects and related mechanisms of a β-blocker combined with a 5-hydroxytryptamine 1A receptor (5-HT1AR) agonist on MI injuries in rats. Methods TTC/Evans blue, H&E, Masson, and TUNEL staining were used to assess infarction area, pathological damage, fibro...

Phantom-based accuracy validation of multimodal ultrasound and C-arm cone-beam CT image fusion for spine navigation

C-arm cone-beam computed tomography (CBCT) provides three-dimensional bony anatomy for spine navigation, whereas tracked ultrasound can provide local radiation-free anatomical information. Accurate fusion remains challenging because of ultrasound artifacts, incomplete surface vis...

Comparative effectiveness of amlodipine versus nifedipine prescribed at discharge in patients with ischemic stroke or transient ischemic attack: A nationwide 5-year follow-up registry study

Background Amlodipine and nifedipine are the most commonly prescribed calcium channel blockers (CCB) for patients suffering from ischemic stroke or transient ischemic attack (TIA). Nevertheless, there is a scarcity of direct comparative evidence on their effectiveness. This study...

Biosynthetic DNA origami nanostructures: harnessing E. coli-phage systems as nanofactories

DNA origami nanostructures (DONs) serve as versatile nanocarriers with promising application potential, but high production cost and low yield limit their development. The biosynthetic approach based on the Escherichia coli ( E. coli )-phage system offers an effective route for t...

Time-Dependent Prognostic Value of the sCD25-to-Ferritin Ratio in Chronic Active Epstein–Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

INTRODUCTION: Chronic active Epstein-Barr virus infection (CAEBV) is an EBV-positive T/NK-cell lymphoproliferative disease characterized by persistent EBV infection in T or NK cells. CAEBV-HLH refers to hemophagocytic lymphohistiocytosis secondary to CAEBV. As important markers o...

Bone health trajectories following regimen optimization in male people living with HIV receiving TDF: a prospective, observational, cohort study

TDF exposure is associated with reduced bone mineral density (BMD) in people living with HIV (PLWH). Data remain limited evaluating changes in BMD and bone turnover markers (BTMs) after switching to tenofovir alafenamide (TAF), TDF/TAF-free regimens such as dolutegravir/lamivudin...

AGDE-Net: a lightweight attention-guided dual-encoder network for tumor core and peritumoral edema segmentation in adult glioma

Abstract Background Glioma is a malignant primary brain tumor arising from glial cells, often resulting in fatal outcomes without timely treatment. Accurate and reliable tumor segmentation is essential for clinical decision-making and therapeutic evaluation. This study aims to de...

Accurate β-Casein Allergen Quantification in Processed Foods via an Isotope-Labeled Full-Length Protein Internal Standard

Abstract Accurate quantification of cow’s milk allergens in processed foods by UPLC-MS/MS is challenged by enzymatic digestion variability and complex matrix effects. β-Casein, a major milk allergen, requires reliable quantification. Herein, we developed a novel method for quanti...

Chemical Stabilization and Retention-Predictive Modeling for Regiospecific Profiling of Labile Monoacylglycerols by UHPLC–HRMS

Abstract Regiospecific analysis of monoacylglycerols (MAGs) remains challenging because of their low endogenous abundance, the limited availability of regioisomeric standards, and rapid acyl migration between the sn-1 and sn-2 positions during sample handling. Here, we report an...

High-intensity transcranial alternating current stimulation improves sleep quality in patients with mild Alzheimer's disease: Findings from the TRANSFORM-AD study

Background High-intensity transcranial alternating current stimulation (Hi-tACS) has shown beneficial effects on cognitive function in Alzheimer's disease (AD). However, data on the effects of hi-tACS on sleep quality and emotional state in patients with AD are still limited. Obj...

Remote‐Controlled Genetic Circuits: Light, Ultrasound, and Magnetic Fields for Programmable Gene Regulation

Remote-controlled genetic circuits use externally applied physical signals to regulate gene expression and cellular functions with spatial and temporal precision. Light, ultrasound, and magnetic fields provide complementary advantages in controllability, tissue accessibility, and...