Research works

Association of the triglyceride-glucose index with prostate cancer risk and prognosis: a systematic review and meta-analysis

The triglyceride-glucose (TyG) index has emerged as a convenient and reliable surrogate marker for insulin resistance (IR) and has been linked to an increased risk of several malignancies. However, its association with prostate cancer (PCa) risk remains uncertain. We therefore co...

Analysis of Pharmacist Interventions during Remote Accompaniment to Physician’s Home Visits in a Medically Underserved Area: A Comparative Study with Conventional In-Person Practice

Participation of pharmacists during physicians’ home visits is effective in home healthcare. However, substantial practical barriers exist in regions where medical resources are unevenly distributed. This study sought to clarify the effectiveness and limitations of a hybrid onlin...

Exosomal microRNAs in tumor–heart crosstalk: nanobiological mechanisms and therapeutic implications

Exosomes are nanosized extracellular vesicles (30–200 nm) that function as natural nanocarriers for intercellular communication by transporting biological macromolecules, particularly microRNAs (miRNAs). These small, non-coding RNA macromolecules regulate gene expression post-tra...

Reliability and validity of the modified chinese version of new Cleveland clinic colorectal cancer quality of life questionnaire

The New Cleveland Clinic Colorectal Cancer Quality of Life Questionnaire (CCF-CaQL) was developed to assess postoperative quality of life (QoL) in patients with colorectal cancer (CRC). Since its introduction, it has been validated in several countries. This study aimed to evalua...

Genome-wide characterization of the SnRK gene family in jujube (Ziziphus jujuba Mill.) reveals that ZjSnRK7 and ZjSnRK9 may contribute to salt stress tolerance

During the plant life cycle, biotic and abiotic stresses critically influence survival and development. Sucrose non-fermenting 1-related protein kinases (SnRKs)-a conserved class of key signaling regulators-play a central role in stress response mechanisms shaped by long-term pla...

How long can suction drains be safely retained after surgery for musculoskeletal malignant tumors?

In orthopaedic surgery, prolonged suction drainage has been associated with an increased risk of infection, and drain removal within 24 h is generally recommended. However, whether this recommendation applies to musculoskeletal tumor surgery, which is often more invasive and asso...

Comparative evaluation of decision tree and random forest models for multi-class water quality classification of the Yamuna river

Monitoring the quality of water in rivers is important for environmental sustainability. This study presents a comparison of Decision Tree (DT) and Random Forest (RF) classifiers for multi-class classification of the water quality of the Yamuna River on the basis of temperature,...

Hybrid dynamic feature convolution with transformer fusion model for the detection of intrusion during manufacturing process

Intrusion detection is essential in contemporary manufacturing systems. These are vulnerable to various cyber threats due to the integration of cyber-physical systems and continuous data exchange. Traditional intrusion detection systems include statistical models and standard mac...

How reliable is percutaneous transforaminal endoscopic discectomy during the learning curve? A comparison of outcomes with microsurgical discectomy experiences

We aimed to share our early experience with percutaneous transforaminal endoscopic discectomy (PTED) during the initial phase of the learning curve and to compare its clinical and perioperative outcomes with microsurgical discectomy (MD) in selected patients with symptomatic lumb...

Magnetic fields and agro-industrial by-products as sustainable approaches to enhance carotenoid and lipid production by Rhodotorula mucilaginosa

This study aimed to evaluate magnetic fields (MF) and agro-industrial media as sustainable approaches to produce carotenoids and lipids by Rhodotorula mucilaginosa. Cultivations were carried out in shaken flasks with previously optimized agro-industrial media with sugarcane molas...

Dental caries among 12-year-old adolescents in shanghai: a cross-sectional study on prevalence, severity, and associated risk factors

This study aimed to assess the prevalence, severity, and associated factors of dental caries in permanent teeth among 12-year-old adolescents in Shanghai, China. A cross-sectional study was conducted in 2021 among 1,305 adolescents from six randomly selected districts. Clinical e...

An Action-masking and Self-labeling-based Learning Method for Block Sequencing and Bay Assignment Optimization in Shipbuilding Panel Lines

The block sequencing and bay assignment problem in a shipbuilding panel line is a complex combinatorial scheduling problem in which upstream serial processes and downstream parallel bay processes are coupled under multiple operational constraints. In practical panel-line planning...

Robust State Estimation via Dual-threshold NIS-based Kalman-FIR Switching

This study proposes a robust state estimation framework for discrete-time linear time-invariant systems using a statistically grounded switching mechanism between the Kalman filter (KF) and the optimal finite impulse response (OFIR) filter. While the KF provides minimum-variance...

Latent subtypes and gender differences in the comorbidity of depression and sleep disturbances among adolescents: insights from network analysis and latent profile analysis

This study aimed to explore potential subtypes, influencing factors, and gender differences in the associations between adolescent depression and sleep disorders. A cross-sectional study was conducted among adolescents utilizing the Center for Epidemiologic Studies Depression Sca...

A Novel Methodology for Temporal Analysis of Consumer Wearable Sleep Data: Feasibility and Application to Early Cognitive Impairment

While sleep disturbances are recognized as early markers of Alzheimer's disease (AD), the practical application of gold-standard polysomnography (PSG) for long-term monitoring is limited. This study aims to establish a novel methodological framework for the time-series analysis o...

Comparative phytotoxicity of PFOS and its substitute OBS in mulberry and implications for a mulberry-silkworm exposure system

Perfluorooctane sulfonic acid (PFOS) is a persistent perfluoroalkyl substance known to exert adverse effects on soil and terrestrial ecosystems. However, the toxicological risks of its substitutes, particularly sodium p-perfluorinated nonenoxybenzene sulfonate (OBS), and their im...

Suspected donor-vessel ischemia in a collateral-dependent right coronary artery occlusion presenting as a de Winter-like pattern with inferior ST-segment elevation: a case report

The de Winter electrocardiographic pattern is a recognized equivalent of ST-segment elevation myocardial infarction and is most commonly associated with acute left anterior descending artery ischemia. Its coexistence with overt ST-segment elevation in another territory is uncommo...

Concurrent chemoradiotherapy for metastatic vulvar extramammary Paget’s disease involving supraclavicular nodes: a case report

Extramammary Paget's disease (EMPD) is a rare adenocarcinoma with a poor prognosis when invasive.Here, we report an exceptionally rare case of invasive vulvar EMPD in a 70-year-old woman who presented with extensive lymphadenopathy involving the inguinal, pelvic, para-aortic, and...

Effects of monensin residues on microbial community and the attenuation of antibiotic resistance genes during chicken manure composting

Monensin is a polyether ionophore antibiotic widely used to prevent coccidiosis and inhibit Gram-positive bacteria. Composting is widely regarded as an effective strategy for reducing the abundance of antibiotic resistance genes (ARGs) in manure. However, the long half-life of mo...

Mode of diagnosis of metastatic breast cancer recurrence and survival: a retrospective study

Randomized studies failed to show a survival benefit for screening asymptomatic breast cancer (BC) survivors for metastases, however, their relevance to the era of modern systemic therapies is unknown. Socioeconomic status (SES) may confound the association between mode of diagno...