Research works

Akkermansia muciniphila attenuates Brucella infection: TLR4−associated inflammatory regulation and gut microbiota remodeling

Akkermansia muciniphila ( A. muciniphila ) is a promising next-generation probiotic with well-established beneficial effects on metabolic disorders, inflammatory diseases, and host immunity. However, whether A. muciniphila protects against Brucella infection remains unknown. Here...

Scale-Dependent Dimensional Trapping: A Topologically Invariant Unified Framework for Galactic Dynamics, Quantum Leakage, and Cosmological Observables

We present Scale-Dependent Dimensional Trapping, a scale-invariant geometric framework that unifies galactic dynamics, quantum gravity attenuation, and cosmological observables without requiring non-baryonic dark matter, dark energy constants, or fine-tuned parameters. By establi...

A Case of Prophylactic Innominate Artery Transection Followed by Laryngotracheal Separation for Tracheal Stenosis Caused by Innominate Artery Compression and Severe Dysphagia

気管切開術後の合併症の中でも重篤かつ致命的なものとして気管腕頭動脈瘻が知られている。気管腕頭動脈瘻を確実に回避する方法として予防的腕頭動脈離断術があるが，明確な適応基準は確立されていない。今回われわれは腕頭動脈による気管狭窄および重度嚥下障害に対して予防的腕頭動脈離断術後に喉頭気...

Effectiveness and Challenges of Protocol-Based Pharmacotherapy Management for Postpartum Rubella Vaccination During the COVID-19 Pandemic

Rubella vaccination is recommended postpartum for women with low rubella antibody titers to prevent congenital rubella syndrome. At our hospital, we have introduced protocol-based pharmacotherapy management (PBPM) for postpartum rubella vaccination, with pharmacists actively invo...

High-intensity circuit training as a potential modulator of serum PFAS levels in women

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with potential physiological effects. Their accumulation in the body is well documented; however, the impact of high-intensity circuit training (HICT) on serum PFAS levels remains poorly understo...

Modulatory effects of branched-chain amino acid supplementation on neuroendocrine disturbances following traumatic brain injury in rats

Traumatic brain injury (TBI) is frequently accompanied by neuroendocrine disturbances involving the hypothalamic–pituitary–thyroid (HPT) axis and vitamin D–calcium–phosphorus homeostasis. Despite increasing interest in nutritional strategies after TBI, the effects of branched-cha...

Beyond the “Benign” Label: Toward Phenotype-Specific Risk Stratification in Apical Hypertrophic Cardiomyopathy

Apical hypertrophic cardiomyopathy (HCM) was first described nearly 5 decades ago by Yamaguchi and colleagues 1) in a Japanese cohort, characterized by giant T-wave inversion and the now-iconic "ace-of-spades" left ventricular morphology, and reported at the time with strikingly...

The deaf profession: Why near-misses do not travel in a hierarchical safety system

Near-miss reporting is widely promoted as a prerequisite for preventive organisational learning, yet many safety–critical organisations continue to learn primarily after harm has occurred. This qualitative study examines why near-miss information fails to travel and convert into...

Study on Image-based Life-saving Ring Launching Method for Multiple Surface Rescue Targets

In recent years, the need for surface life-saving has been gradually increasing as a response to accidents such as ship collisions in the marine environment. To solve this problem, there were approaches that launched life-saving rings or approached humans closely using rescue rob...

Optimization of Stropharia rugosoannulata extracts using artificial intelligence and response surface methodology and comparative evaluation of their biological activities

Stropharia rugosoannulata Farl. ex Murrill is an edible mushroom species recognized for its nutritional value and potential functional properties. In this study, extraction conditions were optimized to maximize the biological potential of its extracts. Ultrasonically assisted ext...

The effects of different types of micro/nano-plastics on the spread of antibiotic resistance genes in soil-lettuce systems

Micro/nanoplastics are ubiquitous and persistent in soils, serving as potential carriers for the dissemination of antibiotic resistance. This study introduced microplastics and nanoplastics of varying types and sizes into loess soil and black soil to investigate their impact on t...

Climate smart agriculture practices and its pathways to improving factor productivity of vegetables in Amhara Region, Ethiopia

Improving agricultural productivity under climate change and variability remains a significant public challenge in Ethiopia. Climate Smart Agriculture (CSA) practices have been recognized as one of the solutions to improving agricultural productivity and resilience capacity to cl...

Generative AI and the Reconfiguration of Symbolic Authority: Implications of a Psychoanalytic View

Large Language Models (LLMs) such as ChatGPT occupy a novel structural position within contemporary symbolic life. Rather than treating generative AI as a question of machine cognition or ethical governance alone, this article analyzes it as a transformation in the organization o...

Protocol of a randomized controlled trial evaluating telehealth delivery of the Brief Alcohol Screening and Intervention for College Students (BASICS) program

This study is a randomized controlled trial evaluating a telehealth version of the Brief Alcohol Screening and Intervention for College Students (BASICS) program as an equally efficacious alternative to the traditional in-person implementation. The study will recruit 600 college...

Melittin Attenuates Against Circadian Rhythm Disruption-Induced Hepatic Injury Through Antioxidant and Anti-Inflammatory Effects

Background Circadian rhythm disruption (CRD) is a risk factor for metabolic and hepatic disorders. This study aimed to investigate the potential hepatoprotective effects of melittin against liver injury induced by constant light exposure in a rat model. Materials and methods Twen...

A Case of Tracheal Stent Placement under Extracorporeal Membrane Oxygenation for Airway Stenosis Caused by Subcarinal Lymph Node Metastasis from Muscle-Invasive Bladder Cancer

症例は64歳，女性。泌尿器科にて筋層浸潤性膀胱癌の治療後で，当科で非結核性抗酸菌症にて通院中であった。経過中に湿性咳嗽と喘鳴があり，吸入ステロイド薬/長時間作用性β2刺激薬配合剤およびステロイド点滴投与を行った。しかし呼吸困難感が増強し胸部CTを撮影したところ，径30 mmの気管分岐部リンパ...

Correlation between clinical communication competence and transition shock among new nurses: a cross-sectional study

New nurses face severe transition shock when entering clinical practice. Clinical communication competence is one of the essential competencies for clinical nurses and is crucial to the quality of nursing care. However, this competence is affected by various factors, and relevant...

Metabolic-extracellular matrix crosstalk in hepatocellular carcinoma: mechanisms and targeted intervention

Bidirectional crosstalk between metabolic reprogramming and extracellular matrix (ECM) remodeling in hepatocellular carcinoma (HCC) constitutes an important metabolic–ECM regulatory network that contributes to HCC progression. Metabolic derangements disrupt ECM deposition, crossl...

Molar incisor hypomineralisation: a cross-sectional study of knowledge, clinical decision-making, and the influence of clinical experience in aesthetic and restorative dental practice

Molar incisor hypomineralisation (MIH) presents considerable diagnostic and restorative challenges in clinical practice due to its heterogeneous clinical presentation and compromised enamel structure. The present study aimed to evaluate MIH-related knowledge, confidence, and clin...

Prevalence and incidence of dementia with Lewy bodies using current McKeith diagnostic criteria (2017–2020): a population-based study

Dementia with Lewy bodies (DLB) is one of the most common neurodegenerative dementias in older adults but remains frequently underdiagnosed in routine clinical practice. Epidemiological data are limited and heterogeneous, and only a small number of population-based studies have a...