Research works

Evaluation of the Impact of Summer Environmental Conditions on the Handling Convenience of Over-the-Counter Soft Capsules Based on Cases Where Liquid Contents Splashed During Removal from Press-Through Packaging

We investigated the impact of temperature and humidity on the convenience of handling over-the-counter (OTC) soft capsule drugs. Following a report of capsule rupture and liquid leakage in Product A, we performed controlled experiments using five products, including Product A. Ca...

Early On-Treatment Host Fitness Dynamics Refine Prognostic Stratification in Advanced NSCLC Receiving First-Line Immunotherapy

PurposeWe assessed whether baseline and early on-treatment measurements of host fitness using the Prognostic Nutritional Index (PNI) provide complementary prognostic information in advanced non-small cell lung cancer (NSCLC). Materials and MethodsWithin the prospective, multicent...

Perioperative Imatinib Treatment Continuation Patterns and Long-Term Outcomes in Locally Advanced Gastrointestinal Stromal Tumors After Neoadjuvant Therapy: An Exploratory Two-Center Retrospective Study

Perioperative Imatinib Treatment Continuation Patterns and Long-Term Outcomes in Locally Advanced Gastrointestinal Stromal Tumors After Neoadjuvant Therapy: An Exploratory Two-Center Retrospective Study

Analgesic efficacy of 0.75% ropivacaine versus 2% lidocaine after unilateral mandibular third molar extraction: a prospective observational cohort study

This prospective observational cohort study aimed to evaluate the clinical efficacy of 0.75% ropivacaine in unilateral mandibular third molar extraction and to compare its postoperative analgesic outcomes with those of 2% lidocaine. A total of 128 patients undergoing unilateral m...

A review: the development of terahertz meta-devices using artificial intelligence technology in advanced optoelectronic applications

Artificial intelligence (AI) techniques have been increasingly integrated into the design and optimization of metamaterial devices (meta-devices). This approach reduces the dependence on conventional methods that require extensive expertise in electromagnetic theory and time-cons...

Incidence, risk factors, and outcomes of postanaesthetic complications: a prospective cohort study in the Mulago National Referral Hospital adult postanaesthesia care unit

Postanaesthetic complications in the postanaesthesia care unit (PACU) carry significant implications for patient recovery, contributing to increased morbidity, prolonged PACU stays, and unplanned ICU admissions where bed availability is limited. Standardised postanaesthetic care...

V-Shape Lumbar Bridge: postural reduction combined with percutaneous vertebroplasty for the treatment of osteoporotic compression fractures

The aim of the current study was to explore the surgical effect, imaging parameters and complications of “V-Shape Lumbar Bridge” postural reduction combined with percutaneous vertebroplasty strategy for treatment of osteoporotic vertebral compression fractures (OVCF) and severe o...

The role of urban agriculture in mitigating urban poverty

Urban agriculture is neglected by policy makers, researchers and urban planners in Ethiopia in general and in research area in particular. Moreover, there are controversial ideas concerning its role in household poverty alleviation. In a modest attempt to fill in the research gap...

Autonomous Computational Law with StellarEq and ACRPL Model

** Autonomous Computational Law with StellarEq and ACRPL Model ** To address the systemic vulnerabilities of legacy natural-language governance—specifically its semantic ambiguity, high-latency auditability, and susceptibility to centralization—this paper presents a mathematicall...

Post-translational modifications of integrins: molecular mechanisms and pathological implications

Integrins are cell-surface adhesion receptors that mediate bidirectional signaling governing migration, proliferation, and survival. Emerging evidence reveals that integrin function is finely controlled by an interconnected network of post-translational modifications (PTMs), span...

A Case Study on Integrated Winterization Design of Accommodation Areas for Arctic-Route LNG Carriers

This paper presents a systematic documentation of Winterization design practice applied to the accommodation area of an Arctic-route LNG carrier, based on direct design experience with a 170K CBM LNG ICE2 CLASS vessel(Winterization notation: − 30℃) ordered by Sovcomflot. In compl...

The utility of trehalose and niclosamide in modulating autophagy to inhibit Leishmania major infection in macrophage cells in vitro

Leishmaniasis is classified as a neglected tropical disease that the available anti-leishmanial medications are limited, often accompanied by side effects, high costs, and the necessity for prolonged treatment. Factors such as the diversity of species, drug resistance of the para...

Exploring the molecular pathways of Noncoding RNAs in ovarian cancer: insights into treatment resistance

Ovarian cancer ranks as the third most common gynecological malignancy, yet it has the highest mortality and recurrence rates among all gynecologic cancers. Chemotherapy combined with immunomodulators and targeted agents, including PTX, ADR, PARPi, and platinum-based chemotherape...

Optimal surgical margin and the efficacy of adjuvant radiotherapy in borderline and malignant phyllodes tumors: a multicenter retrospective study

Purpose: Optimal management of borderline and malignant phyllodes tumors (PT) is not well established, especially regarding margin width and the use of adjuvant radiotherapy (RT).This multicenter study aimed to identify prognostic factors and to assess the effectiveness of adjuva...

Strengthening malaria case management in Plateau State through on-the-job mentorship and supervision: evaluating the effects of targeted capacity building on diagnostic accuracy and data quality

Malaria remains a leading cause of morbidity and mortality in Nigeria, where weaknesses in diagnosis, treatment, and data quality persist. This study evaluated the impact of an integrated on-the-job mentorship and supportive supervision (OJMS) model on malaria case management in...

CT-based three-dimensional virtual reduction with implant templating for tibial plateau fractures involving the posterolateral region: a retrospective cohort study of early postoperative CT reduction quality

Tibial plateau fractures involving the posterolateral region remain technically challenging because of their deep location, limited surgical exposure, and surrounding anatomical constraints. This study investigated whether CT-based three-dimensional virtual reduction with implant...

Inhibition of miR-106a/b Modulates Autophagy-Related Gene Expression in the ULK1–Beclin-1–ATG12 Axis in Experimental Colitis

This study investigated the role of miR-106a and miR-106b in autophagy in a dextran sulfate sodium (DSS)-induced colitis model. DSS induced experimental colitis in Wistar rats, divided into control, DSS-induced-colitis, DSS + AntimiR-106a, DSS + AntimiR-106b, and DSS + scrambled...

A lifespan perspective on stress and happiness: a qualitative metaphor analysis of young and older adults

This study examines the metaphorical perceptions of ‘stress’ and ‘happiness’ among older and younger individuals. The sample consisted of 367 participants (185 young adults and 182 older adults). Data were collected through a structured form including sociodemographic questions a...

Evaluation of Cavitation and Noise Performance of Composite Propellers for Underwater Vehicles using a Large Cavitation Tunnel

Unlike conventional metallic propellers, composite propellers for underwater vehicles exhibit hydroelastic deformation under operating loads and therefore require evaluation methods that account for both hydrodynamic loading and structural deformation. In this study, model tests...

Pharmacist–Physician Task Sharing for Anti-MRSA TDM Orders in a Cancer Center: A Retrospective Before-and-After Study

In August 2025, we implemented physician-pharmacist task sharing for therapeutic drug monitoring (TDM) of anti-methicillin-resistant Staphylococcus aureus agents. Before implementation, physicians entered initial and follow-up TDM orders after pharmacist feedback, but afterward,...