Reusable R analysis modules accompanying "Multi-scale integration identifies an ox-LDL-autophagy-inflammasome framework linking osteoporosis and neurodegeneration"

Abstract

This software package accompanies the manuscript Multi-scale integration identifies an ox-LDL-autophagy-inflammasome framework linking osteoporosis and neurodegeneration. The package contains six reusable R modules for data input and validation, statistical and complex-survey analysis, Mendelian randomization from already harmonised instruments, ordinary differential equation analysis, transcriptomic analysis, and plotting. Functions operate on caller-supplied data, column mappings, groups, gene sets, model equations, and parameters. The archive includes a README, a dependency version inventory, and an MIT license.