Research works

Efficacy and safety of radiofrequency ablation for high-risk locations of T1aN0M0 papillary thyroid carcinoma: a retrospective cohort study

The 2024 Expert Consensus has broadened the potential indications for thermal ablation in papillary thyroid carcinoma (PTC). This study classified PTC nodule locations to assess the efficacy and safety of radiofrequency ablation (RFA) for T1aN0M0 PTC in high-risk locations (HRL)....

Suppression of thermal runaway in lithium-ion battery modules using zonal variable flow immersion cooling

The temperature sensitivity of lithium-ion battery modules is well recognized, and the requirements under normal operation and extreme thermal runaway conditions cannot be simultaneously satisfied by conventional thermal management strategies. A baffle-assisted zonal variable-flo...

Thermal runaway propagation and suppression in power Lithium-ion battery modules: an experimental comparison of module connectivity and thermal barriers

Thermal runaway propagation (TRP) in lithium-ion battery modules depends on cell chemistry, geometry, thermal boundary conditions, and intercell transport paths. This exploratory study compared an electrically connected 4-parallel/2-series (4P × 2S) module with a geometrically si...

Modulating d-band centers in FeNiP@Cu2S nanoarrays by Co-Mn synergistic doping and heterojunction for efficient overall water splitting

This work addresses electrocatalytic limitations via d-band tuning through bimetallic co-doping and heterostructures. A CoMn-FeNiP@Cu 2 S nanorod heterostructured electrocatalyst was synthesized via hydrothermal and electrodeposition methods. Benefiting from the Cu 2 S substrate'...

An Evidence-Graded Framework for Pharmaceutical Route Selection and Process-Risk Prioritization: A PN6047 Case Study

Purpose: To develop and demonstrate an evidence-graded framework for screening discovery-scale synthetic routes before experimental process development, using the publicly disclosed route to PN6047, a clinical-stage δ-opioid receptor agonist, as a case study. Methods: No synthesi...

Immune checkpoint inhibitors for African people living with HIV: T-cell exhaustion, endemic co-infections, and the oncology trial gap

Immune checkpoint inhibitors (ICIs) have fundamentally transformed modern oncology by unleashing the body’s anti-tumor immunity, yet people living with HIV (PLWH) were systematically excluded from the pivotal registration trials. This evidence gap is especially consequential in s...

The role of cold stratification duration in the germination of carnivorous plants under changing environmental conditions

Climate change, distinct from short-term temperature fluctuations, encompasses long-term shifts in environmental conditions and poses a major threat to biodiversity—particularly for habitat-specialist species such as Drosera intermedia and Drosera rotundifolia . These carnivorous...

Robotic cholecystectomy as a step-up procedure after 1,000 consecutive laparoscopic cholecystectomies: learning curve and perioperative outcomes

We analysed the learning curve and perioperative outcomes of 150 consecutive robotic cholecystectomies (RC) performed as a deliberate step-up after 1,000 prior laparoscopic cholecystectomies (LC) at a single institution, and contextualised findings within a systematic review of t...

Prevalence of frailty and associated factors among aging residents with chronic schizophrenia in Taiwanese psychiatric nursing home: a cross-sectional study

Frailty is a critical geriatric syndrome reflecting health vulnerability, yet research among residents with chronic schizophrenia remains limited. This study investigated the prevalence and associated factors of frailty in a psychiatric nursing home. A cross-sectional survey was...

Unravelling the potential of date palm seeds for sustainable biodiesel production

The demand for sustainable energy is increasing due to interest in non-edible and waste-derived biodiesel. The date palm is a well-known plant and produces delicious fruit, with its seed often considered a byproduct. It’s a powerful source for natural oil production and has uniqu...

Drought memory and vegetation shifts triggered by recurrent extreme drought events in alpine peatlands amplify the sensitivity of carbon sink function to drought

Climate change is expected to intensify the frequency and severity of extreme drought events, profoundly influencing terrestrial ecosystem carbon budgets. Peatlands are crucial carbon reservoirs in the global carbon cycle, storing nearly one-third of the world's soil carbon. Howe...

The circulating lipidome in severe obesity

Severe obesity (SevO; BMI ≥ 40 kg/m 2 ) is rising globally yet remains understudied mechanistically. To characterize lipidomic alterations at the species level, we analyzed Border Health Research Cohort participants with fasting plasma lipidomics and genetic data, comparing SevO...

Formation of Eo-Paleoarchean continental crust through intracrustal reworking of differentiated Hadean crust in the Bastar Craton, India

ABSTRACT The generation of Earth’s earliest continental crust remains a fundamental question in understanding planetary differentiation and geodynamic evolution. Globally, Eo-Paleoarchean tonalite-trondhjemite-granodiorite (TTG) rocks record complex magmatic histories involving b...

HIF1α-dependent GGT5 expression promotes gastric cancer progression under hypoxia

The hypoxic tumor microenvironment fosters rapid growth and metastasis of carcinomas. Glutathione (GSH) plays a pivotal role in tumor metabolism. Understanding the mechanisms underlying GSH metabolism, including the role of hypoxia-inducible factor 1-alpha (HIF1α) in gastric canc...

Flow-driven prediction of bluff body fluid–structure interaction

Wind-resistant shape design exploration of civil engineering structures fundamentally relies on the accurate interpolation and extrapolation of bluff-body aerodynamic features. Current methodologies typically emulate global, integrated coefficients, such as flutter derivatives an...

Protocol aware machine learning for prediction and selection of flooding recovery strategies in open cathode PEM fuel cells without recovery transient measurements

A protocol aware machine learning framework enables prediction and selection of flooding recovery strategies in open cathode PEM fuel cells without measuring the recovery transient. Four recovery modes, step-up, pulse-up, ramp-up, and short-circuit pulse, are characterized over 1...

Primary Aldosteronism Severity Grading: Missing the Mark for the Moderate Majority

Elisabeth Ng, Adina F Turcu; Primary Aldosteronism Severity Grading: Missing the Mark for the Moderate Majority, The Journal of Clinical Endocrinology & Me

Cold atmospheric plasma for wound healing: Toward AI-guided therapeutic optimization

Acute and chronic wounds are still a major clinical problem and the therapeutic response to cold atmospheric plasma (CAP) is highly dependent on the device architecture, the delivered dose, the wound characteristics and the treatment protocol. This review critically discusses the...

Enantiomer-racemate regulated material photoluminescence

Chiral and racemic forms of the same molecular components can adopt distinct molecular packing arrangements, leading to differences in crystal structures, intermolecular interactions, and consequently photophysical properties. This review focuses on how chiral/racemic packing and...

Tunnel-wall-monitoring-based probabilistic risk assessment and inverse control of train-induced ground vibration in metro tunnels

Long-term vibration monitoring in operational metro tunnels provides valuable information for evaluating train-induced ground-surface vibration and its environmental impact. However, it remains challenging to determine whether the ground-surface vibration satisfies environmental...