Research works

Idylla™ POLE-POLD1 mutation assay for molecular characterization and risk stratification of endometrial cancers: a retrospective multicenter validation study

Endometrial carcinoma (EC) is a common gynecological cancer with rising incidence driven by obesity and aging populations. Accurate and timely molecular classification is critical for guiding personalized oncology treatment, especially in early-stage high-grade endometrioid carci...

From Bench to Bedside: Clinical Implications of a 4-Micron Surface-Modulated Immune Response in the Era of Breast Tissue Preservation.

Breast implant surface topography plays a critical role in modulating host immune responses and long-term clinical outcomes. Although traditional classifications dichotomize implant surfaces as smooth or textured, emerging evidence demonstrates that specific architectural paramet...

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

Abstract Daraxonrasib is an orally bioavailable RAS(ON) multi-selective tri-complex inhibitor of the oncogenic mutant and wild-type variants of N, H and KRAS. We previously reported encouraging efficacy in a phase 1/2 clinical trial evaluating daraxonrasib monotherapy at clinical...

A programmable DNA origami nanosyringe for directed membrane translocation

Abstract Bacterial contractile injection systems provide a model for membrane penetration and targeted delivery of molecular cargo through mechanical actuation. Replicating these features in synthetic nanoscale systems remains challenging, particularly with respect to coupling st...

Diagnostic value of piezogenic papules in childhood: A scoping review and analysis of existing data

Abstract Introduction Piezogenic papules (PP) are soft, skin-colored or yellowish herniations of subcutaneous fat appearing under pressure, commonly on the heels. While usually benign, they may cause pain and have been associated with Ehlers-Danlos syndrome. PP are included in th...

A Hybrid Lifestyle Program and Metabolic Health in Adults With Obesity

Importance: Obesity disproportionately affects low- and middle-income countries, where access to structured, scalable treatment remains limited. Objective: To evaluate whether a hybrid-format, intensive lifestyle modification program combined with usual medical care promotes a mi...

Design Preferences for Mental Health Apps Among Nondigitally Native Adults With Chronic Pain: Qualitative Analysis

Background On a population level, mental health apps are accessible and effective. However, nondigitally native adults with chronic pain are a large and growing population who have been neglected during the development process of these interventions. Although technology use is ra...

Privatisation of Request Infant Male Circumcision in Australia—An Equity-Focused Assessment of Impacts on Religious Communities in Greater Sydney

Background/Objectives: Infant male circumcision (IMC) is a long-established religious practice in Jewish, Muslim, and some Orthodox Christian communities. Since 2007, access to non-therapeutic request IMC in Australia has gradually shifted from the public healthcare system to the...

A Clock Made of Relations: Intrinsic duration for a system of interacting parts, and the one-sided nonlinearity that hid it for thirteen attempts

Can the duration a process has lived be computed from its own internal relations rather than read off an external clock? Hodos Chronos, the fourth member of the Hodos family, first measured duration as arc length through a statistical manifold. That construction failed a sampling...

Value maximization through fund raising and fund retirement: evidence from globally performing private equity companies

Abstract The companies across the world achieve value maximization of their respective companies by generating profits and/or capitalization/recapitalization. The private equity fund companies achieve value maximization by investing in unlisted high growth companies and/or capita...

Three Patterns Defeat an Action Ladder: What a Detection-Independent Gate for a Browser Agent Does and Does Not Contain

Browser agents act inside the user's authenticated session, so a page that smuggles instructions into its own content can borrow the user's authority. The common defence is to detect the malicious text. We built the complementary thing — a gate that never reads content and classi...

Theory of Optical Phase-Memory Correlators (TOPMC): An Axiomatic Design Theory for Refractive Identity, Causal Integrity, and Quantum-Limited Readout

We present the Theory of Optical Phase-Memory Correlators (TOPMC), an axiomatic design theory for storing and authenticating identity and causal history in weak refractive phase patterns, and for reading those patterns under classical matched-filter and optional quantum-optimal (...

The Promethean-Serpent of Eden is the True Founder of Capitalist Libertarianism: A Refutation of the Paleolibertarian Idea that God is a Libertarian

The myth of the creation of Adam and Eve and their expulsion from the Garden of Eden is an allegory demonstrating that God—far from being a libertarian authority who does not intervene in His creation—is quite the opposite: a statist authority who created the first human couple t...

The first complete genome sequence of iris yellow spot virus from South America and comparative analysis with isolates of different geographic origin

Abstract We report the first complete nucleotide sequence of an isolate of iris yellow spot virus (IYSV; Orthotospovirus iridimaculaflavi ) from Brazil. Isolate Br-25 was collected in 2025 in Imbuia, Santa Catarina, from symptomatic onion scapes. The genome of IYSV-Br-25 consiste...

The effects of multiple adverse shocks on household income in rural Vietnam

Purpose This study aims to examine the effects of multiple shocks on different types of household income in rural Vietnam, an agriculture-based developing country. Design/methodology/approach Utilizing panel data from Vietnam Access to Resources Household Survey spanning 2008–201...

Accelerating ambient AI scribe enterprise-scale deployment: Cleveland Clinic’s novel approach to health system-industry partnership

Abstract Artificial intelligence scribes are increasingly common in clinical settings, but a blueprint for deploying them efficiently at scale is lacking. We share information about the Cleveland Clinic’s vendor-health system deployment partnership consisting of four pillars: gov...

Trifunctional Catalysis via Oxalate Supported Pt−Fe Dual Atoms to Break Site Spatial Restriction in Heterogeneous Catalytic Alkyne Hydrosilylation

Abstract The development of heterogeneous catalysts for alkyne hydrosilylation is critical, yet it remains limited by spatially confined metal sites that are inadaptable to multiple substrate activation and steric hindrance, leading to low efficiency and poor Markovnikov selectiv...

Phase-Synchronized Dual-Target Modulation Rescues Long COVID In Silico: A Langevin Dynamics and Pontryagin Optimal Control Approach

Background: Long COVID (Post-Acute Sequelae of SARS-CoV-2, PASC) presents as a heterogeneous, treatment-resistant chronic syndrome. Conventional anti-inflammatory monotherapies frequently fail in clinical trials, exhibiting post-treatment rebound oscillations. We hypothesize that...

Short Elucidating Note 126: Stating the structural falsification theorem for specific paradigms of the form K = L, its main conceptual applications and its extension of Popperian logic and of Kuhnian logic all in compressed form using set theory and sustainability gap theory?

The specific paradigm’s structural falsification theory suggest that paradigms of the conjunctural form K = L or inherently conjunctural paradigms that claim to have such a form invalidate themselves when applying unilateral pressures (e.g. Maximization, optimization, growth, de-...

Bedside assistant models in robotic abdominal and pelvic surgery: a systematic review of operative efficiency, training exposure, and perioperative safety

Robotic surgery depends on effective bedside assistance, yet staffing models vary between physician and non-physician assistants. We systematically reviewed comparative evidence evaluating these models in robotic abdominal and pelvic surgery. A PRISMA compliant systematic review...