Research works

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Abstract Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and anti...

Subgroup variations in effectiveness of femoropopliteal sirolimus versus paclitaxel-coated balloon angioplasty: post hoc results of the randomised SIRONA trial

INTRODUCTION: The randomised SIRONA trial showed that sirolimus-coated balloon (SCB) angioplasty was non-inferior to paclitaxel-coated balloon angioplasty (PCB) regarding femoropopliteal primary patency. There was no difference in clinically driven target lesion revascularisation...

Clinical features of acute and chronic abdominal pain in children admitted to gastroenterology unit

Abstract Background The incidence of abdominal pain in children has been gradually rising. The study aimed to investigate the clinical characteristics of hospitalized children with abdominal pain for making the accurate diagnosis and treatment. Methods This study collected the cl...

Linguistic Evaluability: Preserving Independent Judgment in Artificial Intelligence-Mediated Communication

Artificial intelligence increasingly mediates the language through which societies communicate, interpret, and evaluate knowledge. Existing AI governance approaches emphasize transparency, accountability, documentation, verification, and explanation, yet these mechanisms depend u...

The Al-Olofi General Theory of Finite-Domain Critical Hierarchical Systems as a Unified Spectral Framework for Atomic and Nuclear Structure

The Al-Olofi General Theory of Finite-Domain Critical Hierarchical Systems as a Unified Spectral Framework for Atomic and Nuclear Structure Yazeed Mohammed Al-Olofi Independent Researcher — Sana'a, Yemen ORCID: https://orcid.org/0009-0005-2405-6636 Email: yazeedalolofi6@gmail.com...

Doing Constructivist Grounded Theory Well: A Practical Guide for Hospitalists

Grounded theory offers rich possibilities for health-related qualitative research, yet it is frequently misunderstood. Grounded theory is not simply a coding method, but a rigorous methodological approach, with core elements impacting the entire research process, whose goal is to...

Phase-Synchronized Dual-Target Modulation Rescues Long COVID In Silico: A Langevin Dynamics and Pontryagin Optimal Control Approach

Background: Long COVID (Post-Acute Sequelae of SARS-CoV-2, PASC) presents as a heterogeneous, treatment-resistant chronic syndrome. Conventional anti-inflammatory monotherapies frequently fail in clinical trials, exhibiting post-treatment rebound oscillations. We hypothesize that...

The 7 Color Materials Theory

This paper presents the 7 Color Materials (7CM) Theory, an axiomatic system of music theory that models tonality, musical structure, and musical perception through a small set of formal axioms. The theory describes tonality as a weighted superposition of Monotonalities, and decom...

Wildfire Smoke beyond PM2.5: Distinct ChemicalMixtures and Hazard Profiles

Abstract Despite growing concern about wildfire smoke (WFS) exposure, research has largely focused on fine particle (PM2.5) mass rather than the complex airborne chemical mixtures that may pose distinct health risks. From March to September 2024, passive air samplers in two Briti...

Comparative study of natural rubber and styrene-butadiene rubber blends reinforced with different carbon black grades for tire tread production

In this study, the effect of carbon black (CB) on the properties of natural rubber (NR) and styrene-butadiene rubber (SBR) blends were investigated. Carbon black with different grades, N330 and N550, was used as a reinforcing filler of NR/SBR blends. The rubber compounds were pre...

Verification as an Epistemic Practice: Toward a Philosophical Account of Independent Knowledge Evaluation

Verification occupies a central role in scientific inquiry, historical investigation, legal reasoning, computation, and many other domains of knowledge, yet it has rarely been examined as an epistemic practice in its own right. Philosophical discussions have instead approached ve...

The early dFLC level after autologous stem cell transplantation can predict the long-term prognosis of in patients with light chain amyloidosis

Abstract Recent studies show that the post-treatment difference between involved and uninvolved light chains (dFLC) predicts long-term prognosis in light chain (AL) amyloidosis. However, this issue remains underexplored in patients treated with autologous stem cell transplantatio...

OEE-Based Manufacturing Loss Diagnostics: A Reproducible Synthetic Case Study

This technical paper presents a reproducible Overall Equipment Effectiveness (OEE)-based diagnostic workflow for manufacturing loss analysis. The approach combines correctly aggregated OEE, line-shift and product segmentation, Pareto loss ranking, temporal comparison, and determi...

Hospitalization of Children in Foster Homes: A Canadian Cohort Study

BACKGROUND AND OBJECTIVES: In Canada, approximately 4% to 7% of children live in a foster home during their childhood. This study reports on hospitalizations of children in foster homes, with the hypothesis that rates of hospitalization are higher for children with foster home ex...

Digesta dynamics, nutrition messaging and (ultra)processed food

There are two disparate approaches used to communicate nutritional attributes of foods, based on nutrient composition and food type. Nutrient content fails to account for the rate and site of nutrient absorption, and food type does not differentiate between diverse forms of the s...

Severe steroid-refractory CIP and exploration of potential biomarkers: A case report

We performed targeted next-generation sequencing (tNGS) on bronchoalveolar lavage fluid (BALF) from a 66-year-old male patient with severe steroid-refractory immune checkpoint inhibitor-associated pneumonitis (grade 4). The sequencing generated raw reads on the Illumina platform....

The American Founding Documents and Democratic Social Change: A Constructivist Grounded Theory

Existing social disparities in the United States are inconsistent with the promise of democracy; therefore, there was a need for critical conceptualization of the firstprinciples that undergird American democracy and the genesis of democratic social change in America. This constr...

Three Patterns Defeat an Action Ladder: What a Detection-Independent Gate for a Browser Agent Does and Does Not Contain

Browser agents act inside the user's authenticated session, so a page that smuggles instructions into its own content can borrow the user's authority. The common defence is to detect the malicious text. We built the complementary thing — a gate that never reads content and classi...

Charge-ResonancePolymerization at Donor–AcceptorInterfaces Enables Large-Area Organic Magnetic Membranes

Abstract Electron acceptors such as tetracyanoquinodimethane (TCNQ) and its fluorinated analogue F4TCNQ are foundational to charge-transfer and doping chemistry. At interfaces formed by deposition of these acceptors onto donor substrates, reduced anionic species can naturally coe...

Early reduction of forced-air warming temperature can reduce energy consumption during craniotomy: a prospective randomized trial

Despite their well-known efficacy, forced-air warming during operations has its drawbacks, mainly high energy consumption and risk of hyperthermia. We therefore investigated two warming strategies in a prospective randomized study with the aim of reducing the incidence of hyperth...