Research works

Storage timescales and the crystal growth history recorded in the layered reservoir of the Unit 3 Kulanaokuaiki Tephra Member of the Uēkahuna Ash from Kīlauea volcano

Abstract The Kulanaokuaiki Tephra Unit 3 (900 C.E.) was a subplinian basaltic scoria eruption, the largest known to have occurred at Kīlauea’s summit. The initiation mechanism and cause(s) of this highly hazardous eruption remain poorly understood, particularly as this style of a...

Early Exclusive Enteral Feeding in Preterm Infants: A Meta-Analysis

CONTEXT Early exclusive enteral feeding (EEF) in preterm infants may provide advantages such as improved nutritional delivery, reduced need for intravenous fluids (IVF), and lower health care costs. However, concerns persist regarding adverse outcomes, particularly necrotizing en...

Substance and Scalar: Why GDP Cannot See What Sustains It

GDP compresses an economy into a scalar. A scalar is a dimensionality reduction: thehigh-dimensional structure it projects from — positions within commercial flows, institutionalconfigurations, distributions of trust and capability — cannot be recovered from the projection.This p...

Exploring the pedagogical landscape of mobile social network-supported microlearning in higher education: a community of inquiry perspective

Purpose This scoping review maps mobile social network–supported microlearning (MSNSM) in higher education, identifying research trends and applications and how MSNSM enhances cognitive, social and teaching presence within the community of inquiry (CoI) framework. Design/methodol...

Expanding the cardiac phenotype of homozygous PPA2 variants: insights from a large Finnish family

Abstract Background Cardiomyopathies in children associate with significant morbidity and mortality. PPA2 deficiency is a rare mitochondrial disorder linked to sudden cardiac death in children and adolescents. Most reported cases are post-mortem, with limited data on surviving in...

Pavement Condition Assessment Using Multisource Satellite Data and Deep Learning

Abstract Effective monitoring of pavement conditions plays an important role in ensuring road safety and optimizing maintenance. Traditional inspection methods are labor-intensive and limited in coverage, motivating the use of remote sensing and deep learning for scalable alterna...

ComplexCore-Satellite Nanoparticles with Trench-StructuredShells and Cavities for Highly Sensitive SERS-Based Lateral Flow Assays

Abstract Herein, we report a multistep synthetic strategy for the fabrication of complex and multifunctional core-satellite nanoparticles with trench-structured shells and cavities (CSTs). Starting from cuboctahedral Au nanoparticles, Pt, Ag, and Au were sequentially deposited in...

Timing the origin: chromatin, transcription, and the spatiotemporal control of eukaryotic DNA replication

Abstract The eukaryotic genome is replicated according to a tightly regulated temporal program that ensures each DNA segment is copied once per cell cycle. This program reflects the coordinated action of replication origin licensing, chromatin state, transcriptional activity, and...

Asymmetry of inter-joint coordination patterns and variability between dominant and non-dominant legs during landing in young healthy adults: a cross-sectional study

Abstract Background Landing movement usually challenges motor control and causes lower limb injuries. Although asymmetries in landing biomechanics between the dominant and the non-dominant sides have been observed, the side-to-side differences in inter-joint coordination patterns...

Comprehensive characterization and translational implications of the GalnsR384C mouse model of Mucopolysaccharidosis IVA

Abstract Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), leading to progressive accumulation of keratan sulfate (KS) and chondroitin-6-sulfate (C6S) and resulting in systemic skeletal...

Substance and Scalar: Why GDP Cannot See What Sustains It

GDP compresses an economy into a scalar. A scalar is a dimensionality reduction: thehigh-dimensional structure it projects from — positions within commercial flows, institutionalconfigurations, distributions of trust and capability — cannot be recovered from the projection.This p...

Discovery ofHighly Selective Noncovalent MacrocyclicPeptide Inhibitors Suppressing Both TMPRSS2 Protease Activity andViral Receptor Function

Abstract The type II transmembrane serine protease TMPRSS2 plays a critical role in respiratory virus entry, including SARS-CoV-2. Using an mRNA display platform with genetic code reprogramming, we identified macrocyclic peptide (MCP) inhibitors of TMPRSS2 that bound to the TMPRS...

Discretionary Child Protective Services Reporting for Infants With Prenatal Opioid Exposure

OBJECTIVE Hospital guidelines implemented in May 2021 to end reflexive child protective services (CPS) reporting for infants with prenatal substance exposure nearly halved overall reporting rates among infants with prenatal opioid exposure (IPOE). Given concerns that discretionar...

Operator-Based Forward Sensitivity of Transient Interfacial Fluxes Under Localized Relaxation Contrasts

We investigate the transient interfacial-flux response of a spatially localized relaxation contrast embedded in a diffusive dissipative medium. A discrete operator formulation is combined with a forward-sensitivity expansion in the relaxation contrast, allowing the macroscopic re...

Visible-Light-DrivenPorphyrin/ZnO Nanohybrids forUltrasensitive Room-Temperature Triethylamine Sensing

Abstract Real-time monitoring of toxic triethylamine (TEA) at room temperature remains a significant challenge for metal oxide chemiresistors due to their typically high-power consumption and thermal requirements. This work presents a highly responsive, visible-light-activated ga...

Identification of Risk Factors for Postoperative Delirium and Targeted Preventive Strategies in Elderly Patients in the Emergency Surgical ICU

AIM: Elderly patients admitted to the intensive care unit (ICU) after emergency surgery represent a uniquely high-risk population for postoperative delirium (POD). However, the key risk factors specific to this group have not been comprehensively integrated, and a corresponding c...

DPASV detection of metribuzin using the cathodic pretreated boron-doped diamond electrode

Abstract The widespread use of the triazinone herbicide metribuzin (MTZ) demands reliable, rapid, and cost-effective analytical methods for environmental monitoring. In this work, we report, for the first time, the electroanalytical determination of MTZ based on its anodic behavi...

Triptycene-Cored Double [5]Helicene: Chirality Transfervia the R / S Triptycene Core to P / M Helical Motifs

Abstract A series of double [5]helicenes with a triptycene core were synthesized via photocyclization. Single-crystal X-ray analysis unambiguously confirms these helicenes with an R/S triptycene core and two M/P [5]helicene subunits. Transfer of the central axially helical chiral...

Computational study of the CO$$_2$$ hydrogenation to formic acid catalyzed by a P,P-bidentate copper(I) complex

Abstract Context Carbon dioxide (CO $$_2$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mmultiscripts> <mml:mrow/> <mml:mn>2</mml:mn> <mml:mrow/> </mml:mmultiscripts> </mml:math> ) hydrogenation is a promising route for converting CO $$_2$$ <mml:math xmlns:mml="...

Measurement and monitoring framework for nurturing an entrepreneurial climate in higher education institutions

Purpose This paper aims to categorize important organization-initiated drivers of the entrepreneurial climate from academics' perspectives into specific components and develops a comprehensive index, termed the Organizational Drivers of Entrepreneurial Climate for Academics' Inde...