Research works

FastRet: Fast andSimple Retention Time Predictionin Liquid Chromatography

Abstract Feature annotation in liquid chromatography–mass spectrometry (LC–MS)-based untargeted metabolomics remains challenging. Retention time (RT) prediction can support candidate prioritization and improve annotation confidence. Here, we present FastRet, an R package predicti...

Seismic performance degradation of reinforced concrete bridges under climate change

Abstract Under climate change and long-term service conditions, durability problems caused by steel corrosion and concrete deterioration severely weaken the seismic capacity of bridges. In response to the limited existing studies concerning the variation in bridge displacement re...

José Carlos Mariátegui’s Archaic Developmentalism: Utopia, the Incan Empire, and Peruvian Reality

“Developmentalism” refers to the idea that human societies progress through a series of historical stages, along one path or multiple paths, which allows for the comparison and hierarchization of different populations. As numerous works have shown, developmentalism was often call...

Genomic analysis and clinical characteristics of a seasonal upsurge of Streptococcus pyogenes emm12

Abstract Purpose Streptococcus pyogenes cause invasive infections with variable incidence over time. In 2023, an increase in invasive S. pyogenes infections caused by emm- types 1 and 12 was reported globally. In Southern Sweden an increase in S. pyogenes emm 12 severe infections...

Postoperative Interventions and Cost Associated With Disposition After Tonsil and Adenoidectomy

OBJECTIVE To evaluate postoperative disposition and resource use among patients admitted to the inpatient unit or pediatric intensive care unit (PICU) following tonsillectomy, adenoidectomy, and tonsillectomy/adenoidectomy (T/A). PATIENTS AND METHODS This retrospective cohort stu...

Exact Order-Lifting Depth and Ramification in Global Function Fields: A Coefficient-Field Rank Formula and Counterexamples to Kernel-Dimension Conjectures

This preprint studies order lifting for rational functions on curves over finite fields. It identifies order-lifting depth with the local multiplicity of the associated morphism and relates this invariant to Fermat quotients, Hasse derivatives, and the lifting of multiplicative o...

Emergent Architectural Drawing Literacy in General-Purpose GPT Systems: A Longitudinal Case Study from Recognition to BIM Execution

Architectural drawings require more than optical character recognition or object detection: useful interpretation depends on integrating geometry, dimensions, graphical conventions, spatial relations, functional semantics, and discipline-specific knowledge. This preprint presents...

Impacts of land system change− driven urban heat islands on surface water dynamics and moisture conditions in Gauteng Province, South Africa

Abstract Surface water is a scarce resource in Gauteng, South Africa. This study analysed the impacts of urban heat islands on surface water dynamics and moisture conditions from 1984 to 2024 using vegetation and water indices in the Google Earth Engine. The results indicate that...

Modulating pressure in the Orbitrap improves sensitivity and mass resolution in charge detection mass spectrometry

Abstract Native mass spectrometry has become a key method for studying macromolecular assemblies, providing insights into structures, stoichiometries, and binding interactions. A key aspect for the transmission of electrospray-generated bioparticles into the mass analyzer is the...

Remote STrOke Rehabilitation (ReSTORe): study protocol for a randomised controlled trial

Abstract Background At least one third of long-term stroke survivors living at home experience ongoing (≥6 months) mild to moderate disability including fatigue, low functional capacity, muscle weakness, anxiety, and depression. Health-related quality of life (HRQoL) and societal...

Hydrogel-EmpoweredInterfacial Reactive Hydrogen onCopper Enables Selective Nitrate-To-Ammonia Electrocatalysis

Abstract Precise control of interfacial reactive hydrogen is crucial for improving the selectivity of proton-coupled electron transfer reactions in electrocatalysis. In the nitrate electroreduction to ammonia reaction, a fundamental trade-off is identified for copper (Cu)-based c...

Expanding the BiocatalyticToolbox: A Singular P450Enzyme Efficiently Produces Diverse Pharmaceutical Metabolites

Abstract P450 BM3 is a natural fusion protein with a P450 domain fused to its necessary redox partner and capable of binding a range of fatty acids at high catalytic rates. The flexibility of the active site and catalytic efficiency have led to extensive research aimed at modifyi...

From sensory experiences to destination loyalty: evidence from cultural night tourism

Purpose This study examines how sensory experiences shape destination loyalty in cultural night tourism. Drawing on the Stimulus–Organism–Response (S-O-R) framework, it explores how emotional experience and satisfaction contribute to the formation of loyalty in heritage-based nig...

Energy consumption, economic growth, and renewable energy effects on CO2 emissions in Iran: an ARDL–PCA analysis

Abstract Iran is currently grappling with critical environmental and economic challenges, including rising CO 2 emissions, frequent blackouts, and ongoing economic stagnation. Despite a growing body of literature on the energy-emissions nexus, much of it has overlooked the integr...

An Assessment of CCTV Surveillance Infrastructure for Enhancing Highway Security: A Case Study of Third Mainland Bridge, Lagos, Nigeria

Abstract This paper evaluates the role of Closed-Circuit Television (CCTV) surveillance infrastructure in enhancing urban security and traffic management along the Third Mainland Bridge in Lagos, Nigeria. Spanning 11.8 kilometers across the Lagos Lagoon, the bridge is a critical...

Pathogenesis andSustainable Management of Pseudomonas syringae : Emerging Roles of MicrobialConsortia and Responsive Nanomaterials

Abstract Pseudomonas syringae remains a globally devastating phytopathogen threatening over 500 species. This review delineates the biochemical coevolution between P. syringae and hosts, focusing on Type III secretion system (T3SS) effectors and phytotoxins (e.g., coronatine) tha...

The efficacy of suprascapular nerve radiofrequency and intra-articular steroıd injectıon in frozen shoulder treatment: randomızed controlled trial

Abstract Background This study aims to address the impacts of intra-articular steroid injection (IASI) alone versus the combination of suprascapular nerve (SSN) pulsed radiofrequency (PRF) and IASI on pain relief and improvement in shoulder range of motion (ROM) in patients with...

Operator-Based Forward Sensitivity of Transient Interfacial Fluxes Under Localized Relaxation Contrasts

We investigate the transient interfacial-flux response of a spatially localized relaxation contrast embedded in a diffusive dissipative medium. A discrete operator formulation is combined with a forward-sensitivity expansion in the relaxation contrast, allowing the macroscopic re...

Quantile connectedness between African stock markets, Twitter sentiment index, implied volatilities, financial condition index and economic uncertainty

Purpose This study aims to examine the quantile-based time-frequency spillovers between African stock prices and global uncertainty indicators. Design/methodology/approach The study applies the quantile vector autoregressive connectedness framework to daily data (2012–2023) for n...

Influence of cultural factors and user engagement motives on value co-creation dynamics between healthcare service providers and users

Purpose Previous research identifies multiple motives as drivers of value co-creation but reports inconsistent findings across national contexts. This study examines how national culture shapes healthcare service users’ motives and engagement in value co-creation, addressing call...