Research works

Empathy and musical reward sensitivity in middle childhood: a psychometric validation of the Barcelona music reward questionnaire in children aged 7–9

Introduction Music is a highly rewarding experience, yet individuals differ substantially in how pleasurable they find music. In adults, sensitivity to musical reward has been consistently linked to socio-emotional traits, particularly empathy. However, little is known about whet...

Lung tumour secretome and extracellular vesicles: mechanisms, biomarkers, and therapeutic opportunities

Lung cancer progression is governed not only by tumour-intrinsic genetic alterations but also by dynamic communication between tumour cells and the surrounding microenvironment. An important component of this communication is the tumour secretome, comprising soluble factors and e...

I Read the News Today, but Why? Media Consumption, Socialization, and Autocracy

Dominant models of news consumption in political science treat citizens as rational individuals, gathering information to make materially or politically consequential choices. This assumption, developed largely in democratic contexts, risks obscuring other incentives that may be...

A task-aligned multimodal machine learning framework for studying working memory dysfunction in Parkinson’s disease

<title>Abstract</title> Cognitive impairment is one of the most functionally debilitating non-motor symptoms in Parkinson's disease (PD). Yet, current diagnostic and clinical practices rely heavily on subjective assessments and burdensome behavioral testing, which lack the tempor...

Flavin Hydroperoxideand Semiquinone: Structures andBiomimetic Activity

Abstract Flavins are unique natural redox cofactors that can switch between an oxidized, a radical half-reduced, and a fully reduced state. In nature, the interplay between these redox states is orchestrated by the surrounding flavoenzymes and unlocks a myriad of unique chemical...

Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress

LRRK2, the Parkinson's disease-associated kinase, phosphorylates a subset of Rab GTPases and regulates membrane dynamics. We previously reported that lysosomal stress activates LRRK2 and thereby induces the exocytic secretion of lysosomal contents, but the detailed secretion mech...

Island Sliding Barriers: A First-Principles Metricfor Determining Remote Epitaxy Viability

Abstract Remote epitaxy, where a 2D van der Waals material (usually graphene) is inserted on top of the substrate before film epitaxy, has emerged as a promising path for growing electronics with lower defect rates and less stringent lattice matching requirements. The exact mecha...

Hitherto UnrecognizedIntermolecular Coulombic DecayMechanism in Gases

Abstract Excited atoms and molecules can utilize their excess energy to ionize a neighboring system by a process named interatomic and intermolecular Coulombic decay (ICD). ICD is ultrafast, in the femtosecond regime, and has many modes of appearance. Ample applications of ICD ha...

Power weight inequalities for spherical maximal functions

Abstract This paper is about spherical maximal functions with general dilation sets acting on functions in weighted $$L^p(|x|^\alpha )$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mi>L</mml:mi> <mml:mi>p</mml:mi> </mml:msup> <mml:msup> <m...

High-Precision Approximation of Riemann Zeros via the Truncated Weil Form

The Connes–van Suijlekom truncated Weil quadratic form, indexed by a cutoff parameter c that controls the primes p ≤ c entering the operator, produces a ground state whose Fourier–Mellin zeros provably lie on the critical line; whether they converge to the Riemann zeros as c → ∞...

Ambient nitrogen dioxide and composition-specific risk of urolithiasis: a multicenter time-stratified case-crossover study

Background: Emerging evidence suggests that ambient air pollution and meteorological variation may trigger urolithiasis, but stone-composition–specific and lagged associations are poorly characterized.Methods: We conducted a multicenter, time-stratified case-crossover study in Gu...

Bridging local decisions and regional forest strategies under climate risks: a flexibility-based optimization framework

<title>Abstract</title> Context: While the management of forests at a regional level takes into account different forest types and management objectives, the potential effects of projected climate impacts at a sub-regional scale remain largely unexplored. Aims: To better support...

Asymptotics of lowlying Dirichlet eigenvalues of Witten Laplacians on domains in pinned path groups

Abstract Let G be a compact connected Lie group and P e , a ( G ) = C ([0, 1] → G | γ (0) = e , γ (1) = a ) be the pinned path space with a pinned Brownian motion measure ν λ , a defined by the heat kernel p ( λ −1 t , x , y ), where λ is a positive parameter. We consider a Witte...

Deep generative model for human mobility behavior

Understanding and modeling human mobility is central to challenges in transport planning, sustainable urban design, and public health. Despite decades of effort, simulating individual mobility remains challenging because of its complex, context-dependent, and exploratory nature....

Commensal bacteria inhibit viral infections via a tryptophan metabolite

Clinical outcomes following viral exposures exhibit substantial interindividual variability. Although developing evidence suggests commensal bacteria modulate viral infections, the specific bacteria and mechanisms remain underexplored. Here, we define a pathway by which viral inf...

Part VI From Organizational Investment to Strategic Reorientation: From Resource-Based Negotiating Asymmetry to Path-Dependent Structural Change in Larger Systems

Part V examined how selective and sustained investment across functional domains within an organization may produce unequal accumulated organizational capacity and, consequently, unequal potential negotiating capacity among those domains. Part VI extends the underlying structural...

Part VI From Organizational Investment to Strategic Reorientation: From Resource-Based Negotiating Asymmetry to Path-Dependent Structural Change in Larger Systems

Part V examined how selective and sustained investment across functional domains within an organization may produce unequal accumulated organizational capacity and, consequently, unequal potential negotiating capacity among those domains. Part VI extends the underlying structural...

தரககறளல நர சரநத அறம

உலக மக்களின் வாழ்வுக்கு வேண்டிய நல்ல கருத்துகளை கொண்டிருக்கும் காரணத்தினால் திருக்குறள் உலகப் பொதுமறையாகப் போற்றப்படுகிறது. மனிதனின் அடிப்படைத் தேவைகளில் ஒன்றாக விளங்க கூடியது நீர். மனித வாழ்விற்கு மிக முக்கிய தேவையான நீரை திறம்பட மேலாண்மை செய்வதற்கும் தேவைப்படும் காலங்களில் நீரை...

தரககறளல நர சரநத அறம

உலக மக்களின் வாழ்வுக்கு வேண்டிய நல்ல கருத்துகளை கொண்டிருக்கும் காரணத்தினால் திருக்குறள் உலகப் பொதுமறையாகப் போற்றப்படுகிறது. மனிதனின் அடிப்படைத் தேவைகளில் ஒன்றாக விளங்க கூடியது நீர். மனித வாழ்விற்கு மிக முக்கிய தேவையான நீரை திறம்பட மேலாண்மை செய்வதற்கும் தேவைப்படும் காலங்களில் நீரை...

Tax Law and Corporate Tax Planning in East Africa: BEPS and Domestic Response: Gender, Power, and Structural Constraints

This article examines Tax Law and Corporate Tax Planning in East Africa: BEPS and Domestic Response: Gender, Power, and Structural Constraints with a focused emphasis on Rwanda within the field of Law. It is structured as a working paper that organises the problem, the strongest...