Research works

Dose- and Time-Dependent Effects of a Ferula communis Extract on Bone Remodelling in a Human Osteosarcoma Cell Line

Ferula communis is a herbaceous plant in the family Apiaceae and order Apiales. It has two chemotypes that cannot be distinguished botanically, although one is highly toxic while the other is not. The non-poisonous chemotype has many beneficial activities for human health, includ...

Effects of crack inclination and aperture on mechanical properties and fracture behavior of sandstone: an experimental study based on acoustic emission monitoring

The inclination and aperture of rock fractures significantly influence the mechanical properties and crack propagation behavior of rock masses. To investigate the deformation characteristics and crack evolution in sandstone, uniaxial compression tests were conducted on specimens...

Patient-derived models reveal LTBP2-linked collagen I niche that prime adaptive cell plasticity and tune chemoresponse in colorectal cancer

Abstract Background The extracellular matrix (ECM) is a critical component of the tumour microenvironment (TME) and regulates epithelial plasticity and therapeutic responses in colorectal cancer (CRC). However, the mechanisms by which specific ECM components modulate tumour cell...

Unveiling an antimicrobial nonionic surfactant with enhanced surface activity, emulsification, and physicochemical performance

: A nonionic surfactant, tetraethylene glycol monopalmitate (PEG4-P), was produced with a 98% yield using a one-step imidazole-catalyzed esterification reaction. Polyethylene glycol (PEG)-based fatty acid esters have been extensively studied, although low-molecular-weight tetraet...

Multi-camera in-situ monitoring for emissivity-corrected temperature measurement in laser beam directed energy deposition

Abstract Temperature measurement is essential in metal additive manufacturing, as the spatio-thermal profile strongly influences the microstructure and therefore the key mechanical properties of the produced components. Conventional infrared thermography is widely used for in-sit...

The effects of spatial structure on a host-parasite model with horizontal and vertical transmission

Abstract Vertical transmission of an infectious disease from parent to offspring is a common transmission route in many systems. However, the majority of vertical transmission modelling has assumed a well-mixed population, and we do not know how the spatial structure present in m...

Küresel Kamusal Mal Teorisi Çerçevesinde Gıda Güvenliği: Kamu Ekonomisi Temelli Bir Analiz

Bu çalışma, gıda güvenliğini kamu ekonomisi perspektifinden ele alarak kavramın küresel kamusal mal niteliği taşıyıp taşımadığını teorik düzlemde incelemeyi amaçlamaktadır. Bu doğrultuda öncelikle kamusal mal teorisi ve küresel kamusal mallar literatürü çerçevesinde kavramsal bir...

Selective Nickel Leaching from Cu-Ni Sulfide Ores Using Deep Eutectic Solvents

Traditional hydrometallurgical lixiviants such as sulfuric and hydrochloric acid pose environmental and safety risks due to their corrosive and toxic nature. To advance greener extraction technologies, this study evaluated deep eutectic solvents (DESs) as potential sustainable al...

The Lessons from 1970s Price Controls

Abstract There has been a recent revival of interest in both voluntary and mandatory controls of prices to reduce the impact of inflation on low‐income groups. This article reviews the use of voluntary schemes of price restraint by the 1974–9 Labour government, in particular the...

DC/TMD Axis II Instruments and Their Association with MRI-Based Structural Classification of the Temporomandibular Joint and Oral Function in Female Patients with Malocclusion: A Cross-Sectional Study

Background/Objectives: Few studies have examined the associations of the Oral Behaviors Checklist (OBC) and the Jaw Functional Limitation Scale (JFLS) of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Axis II with magnetic resonance imaging (MRI)-based structura...

Desain Ergonomi Alat Pengasapan Ikan dengan Intervensi Internet of Things (IoT) dan Analytical Hierarchy Process (AHP)

Penelitian ini bertujuan untuk mendesain dan mengevaluasi ergonomi alat pengasapan ikan melalui intervensi Internet of Things (IoT), sekaligus menentukan alat pengasapan yang paling aman dan sehat bagi penggunanya serta mengurangi dampak lingkungan yang ditimbulkan, menggunakan m...

Adaptation and Validation of the O*NET Interest Profiler and the O*NET Computerized Work Importance Profiler (WIP-C) in Finland

This study describes the adaptation and validation of two publicly available career exploration tools, the O*NET Interest Profiler (IP) – Short Form and the O*NET Computerized Work Importance Profiler (WIP-C), into the Finnish-language and cultural context. We examined the psycho...

Molecular mechanism of S100A11 inhibiting anti-HCC immune function of NK cells

Objective To explore the regulatory role and underlying molecular mechanism of S100A11 in the anti-hepatocellular carcinoma (HCC) function of natural killer (NK) cells, and to provide a novel target and theoretical basis for optimizing immunotherapy for HCC. Methods The expressio...

Rat Hepatitis E Virus ( RHEV ) in Mus musculus and Rattus norvegicus in Northwestern Italy

INTRODUCTION: Hepatitis E virus (HEV) represents a major public health concern. Beyond the main zoonotic genotypes HEV-3 and HEV-4, with pigs and wild boars recognized as the primary reservoirs of infection, a genetically distinct hepevirus of rodent origin (species Rocahepevirus...

Effectiveness of Recurrent Layers and IndoBERT Regularization for Virtual Assistant Intent Classification on the Indonesian MASSIVE Dataset — Reproducibility Code

Google Colab notebook and original results (state.pkl) that reproduce Tables 2 and 4–10 and Figures 3–4 of the article "Effectiveness of Recurrent Layers and IndoBERT Regularization for Virtual Assistant Intent Classification on the Indonesian MASSIVE Dataset". Eight models are c...

Programable extracellular matrix heterogeneity directs least-resistance migration in three dimensions

Abstract Cell migration through three-dimensional (3D) extracellular matrices (ECMs) is central to development, immune response, and cancer metastasis, yet how cells navigate mechanically heterogeneous environments remains poorly understood. Here we introduce a light-guided in si...

Protective effects of icariin in atherosclerotic cardiovascular disease: mechanistic basis, post-ischemic protection and translational limitations

CONTEXT: Icariin (ICA), a prenylated flavonol glycoside from Epimedii Folium, has been investigated in experimental models relevant to atherosclerosis, myocardial infarction, and ischemic tissue injury. OBJECTIVES: This review evaluates experimental evidence on ICA in atheroscler...

Wing Icing Segmentation from UAV Flight-Test Images Using Wing Surface Spatial Priors and Inter-Frame Smoothing

Wing icing alters the aerodynamic shape of lifting surfaces and threatens aviation safety. Existing icing-image datasets come mainly from wind tunnels or simulations, and image-level random splits overestimate generalisation for video data. We build a real UAV flight-test dataset...

A Wide-Band-Gap Pyromellitic Diimide-Based Coordination Polymer for Selective and Visual Detection of Ultraviolet Rays

Abstract Owing to one of the main factors causing skin cancer by ultraviolet (UV) radiation emitted from the sun, the development of the effective method for selectively detecting UV rays is of great significance for human health. In this work, two compounds, [(H2CMPMD)·2DMF] (1)...

Three Essays on Freedom: Markets, Aparactonomy, and Anarcho-Capitalism.

Three short essays examine obstacles to the realization and persistence of maximum freedom. The first shows that the internal logic of anarcho-capitalism contains no residual contradiction yet collides with feasibility because of human tendencies toward collectivism: once choice...