Research works

Alzheimer’s Disease as a Multi-Layer Network Disorder: A Systems Biology Framework Integrating Multi-Omics Mechanisms

Despite substantial progress in biomarker discovery and multi-omics profiling, several features of Alzheimer’s disease (AD), including prolonged compensated states, heterogeneous clinical trajectories, and marked stage-dependent therapeutic responses, remain difficult to integrat...

A unified mechano-ionic skin for resolving native electromechanical coupling

The beat-to-beat electromechanical coupling between cardiac excitation and arterial pulse propagation encodes vital cardiovascular insights, but resolving this coherence in wearables is hindered by the spatial decoupling of sensors and attenuated epidermal signals. Here, we repor...

Pest Management for Transgenic Cotton in Developing Countries: A Troubled Strategy

Abstract Cotton is an economically important crop in many developing regions but arthropod pests cause enormous losses. Frequent application of synthetic insecticides resulted in pest resistance rendering cotton production unprofitable in many countries. The introduction of trans...

Privacy-preserving federated learning for detection of AI-generated text using hybrid RoBERTa-CNN models in low-resource languages

The rapid adoption of large language models (LLMs) has transformed educational writing while introducing significant challenges for academic integrity and authorship verification. Existing AI-generated text detection systems predominantly rely on centralized cloud-based infrastru...

Among Five First-Trimester Complete Blood Count Inflammatory Indices, the Systemic Inflammation Response Index Rises Most Consistently with the Severity of Preterm Birth

Background/Objectives: Complete blood count inflammatory indices are widely studied in obstetrics but rarely compared directly. We compared five first-trimester indices, the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), pan-immune-inflamma...

Bridging Relational Ontologies: Western Friendship and Chinese Guanxi in Dialogue

International Relations scholarship treats friendship either as a metaphor applied to states or, when it reaches the level of individuals, as an instrument of power; in both cases, the concept loses the relational quality that defines it. This article addresses that deficit by br...

Sexual dimorphism in fetal brain gene co-expression networks as a possible etiological factor of sex-biased autism prevalence

Autism spectrum disorder (ASD) affects more males than females in an approximate ratio of 4:1, yet the biological bases of this imbalance remain unclear. Here, we explored the hypothesis that part of the male-biased vulnerability could arise from sex-specific baseline organizatio...

Longitudinal gradients modulate the distribution, composition, and ecological risk of microplastics in a neotropical public water supply reservoir

Abstract Microplastics (MPs) contamination was assessed in the water and surface sediment in the upstream, dam, and downstream zones of the Tapacurá Reservoir, a tropical public water supply system in northeastern Brazil, over the course of four sampling campaigns. MPs were detec...

Low‐cost robust covalent organic framework with pyridine sites for deep flue gas desulfurization

Abstract The practical deployment of covalent organic frameworks (COFs) for industrial gas separations is hindered by synthetic complexity, high monomer costs, and insufficient stability. We report a pyridine‐functionalized, vinylene‐linked COF (2,4,6‐trimethylpyridine‐terephthal...

Land marketization, fiscal decentralization and carbon emissions

During China’s period of economic transition, its policy of fiscal decentralization (FD) has vigorously promoted China’s economic development, but it has brought about a mass of carbon emissions (CE) from its urban and industrial development. To solve environmental problems, the...

The Illusion of the Artifact Semiotic Indexation and the Genesis of Production in the Age of Generative Artificial Intelligence

This article proposes an ontological distinction between the human artifact and the output of generative artificial intelligence systems, here designated meta-artifact, shifting the contemporarydebate from Bourdieu’s arbitrary symbolic capital toward the semiotic genesis of produ...

The Vaccine–Field Strain Gap in Bovine Neonatal Diarrhea: Molecular Epidemiology of Rotavirus, Coronavirus, and Enterotoxigenic Escherichia coli and Priorities for Vaccine Updating

Bovine neonatal diarrhea (BND) is a leading cause of morbidity and mortality in pre-weaned calves. Commercial maternal vaccines targeting bovine rotavirus (BRV), bovine coronavirus (BCoV), and enterotoxigenic Escherichia coli (ETEC) have been available for decades, yet field outb...

Development and external validation of an inflammation-based nomogram for predicting short-term mortality in cirrhotic patients with esophagogastric variceal bleeding

Abstract Background Early and accurate risk stratification is critical for managing cirrhotic patients with esophagogastric variceal bleeding (EGVB). Inflammatory biomarkers derived from complete blood counts may offer prognostic value, yet their comparative performance remains u...

DSG2 Expression Marks a Stromal-Immune Organizational State in Head and Neck Squamous Cell Carcinoma

Background/Objectives: Immune exclusion in head and neck squamous cell carcinoma (HNSCC) limits immunotherapy efficacy, yet the molecular determinants of stromal-immune organization remain incompletely characterized. The desmosomal cadherin DSG2 is highly expressed in squamous ep...

Molecular Detection and Phylogenetic Characterization of Spotted Fever Group Rickettsiae in Amblyomma javanense Ticks from Illegally Traded Malayan Pangolins

Background: The Malayan pangolin (Manis javanica) is a critically endangered species that may harbor diverse zoonotic pathogens. This study aimed to characterize tick species parasitizing confiscated Malayan pangolins and determine the prevalence and genetic diversity of spotted...

3A Cyanide‐Bridged Ru–Fe Supramolecular Photocatalyst for Efficient CO 2 Reduction

Supramolecular control over electron transfer is a key challenge in artificial photosynthesis. Here, we report a cyano‐bridged Ru–Fe supramolecular photocatalyst that self‐assembles in solution through spontaneous coordination. This preorganized architecture enables ultrafast exc...

Anti-Inflammatory Effects of Ginsenosides: Molecular Mechanisms and Network Pharmacology Analysis

Inflammation is a pathological process central to many chronic diseases. Conventional anti-inflammatories, including NSAIDs and corticosteroids, are limited by adverse effects and suboptimal efficacy with long-term use. Ginsenosides from Panax ginseng have emerged as promising mu...

Genetic Diversity and Population Structure of Wild and Hatchery-Associated Prochilodus magdalenae from Northern Colombia

Maintaining genetic diversity is essential for the long-term conservation of migratory freshwater fishes facing increasing anthropogenic pressures. Prochilodus magdalenae (bocachico), one of Colombia’s most economically and ecologically important freshwater fish species, supports...

Kurumsal Yönetim ve Sürdürülebilirlik İlkelerine Uyum Düzeyinin Kazanç ve Hisse Başına Kazanca Etkisi: BİST Likit Endekslerindeki İşletmeler Üzerine Bir Deneme

Bu çalışmada; BİST Likit Banka ve BİST Banka Dışı Likit 10 endekslerinde yer alan işletmelerin kurumsal yönetim ve sürdürülebilirlik ilkelerine uyum düzeyleri ile kazanç ve hisse başına kazançları arasındaki ilişkinin belirlenmesi amacıyla panel veri analizleri yapılmıştır. Çalış...

The Customer Journey Is Missing a Step

Customer journey models such as Google's See-Think-Do-Care (STDC) and McKinsey's Consumer Decision Journey remain widely used in digital marketing. However, both models leave an important conceptual gap between consideration and purchase. This white paper argues that many of the...