Research works

ProtPen CombinesSequence- and Structure-based Approachesto Facilitate Protein Function Predictions on a Proteome-wide Scale

Abstract Proteins of unknown function represent a significant gap in our understanding of biological processes, encompassing large portions of the proteomes of many organisms, especially prokaryotes. Addressing this gap is critical to understanding the biology and pathogenicity o...

From Physical Grids to Cyber-Energy Digital Twins: Modeling Power System Components for Cyberattack Assessment

Traditional Digital Twins (DTs) in energy sectors lack cyber-threat awareness, while cybersecurity DTs overlook downstream physical impacts. Loosely coupled co-simulations attempt to bridge this gap but introduce computational lags that mask critical cross-domain vulnerabilities....

Quality of Life Outcomes in Patients with Pulmonary Hypertension Receiving Prostacyclin Therapy: Impact of Anxiety, Depression, Sociodemographic Characteristics, and Treatment-Related Factors

OBJECTIVE: Despite advances in prostacyclin therapy, pulmonary hypertension (PH) continues to impair patients' quality of life (QoL). This study aimed to identify the clinical and psychological factors associated with QoL in patients receiving prostacyclin therapy. METHOD: This c...

Eastern European–Asian Cooperation: Aquacultural and Cultural Contributions to Increased Fish Consumption in Laos

Laos is one of the 32 landlocked developing countries (LLDCs) of the world, where isolation from the sea and the lack of a large-scale fishing industry have a direct effect on fish supply and fish consumption. Per capita fish consumption in LLDCs amounted to 5.1 kg/year in 2023,...

Data-driven prediction of fifteen-year all-cause mortality among 2.3 million individuals in the VA

ABSTRACT We present a data-driven framework to predict 15-year all-cause mortality using outpatient administrative records for 2.3 million Veterans in the largest integrated U.S. healthcare system. Rather than relying on predefined clinical phenotypes, we used the 1,000 most comm...

GANCIU—Geospatial Analysis with Neural Classification and Image Understanding

Accurate and up-to-date knowledge of land use and land cover represents one of the central challenges in spatial planning and landscape sciences. In this context, the present work introduces GANCIU (Geospatial Analysis with Neural Classification and Image Understanding), an origi...

A Decision-Diagram Framework for Conflict Detection in Multi-Layer Cilium Network Policies

Cilium is among the most widely deployed Container Network Interfaces (CNIs), serving as the default CNI in the Google Kubernetes Engine. It extends standard Kubernetes NetworkPolicy (KNP) with two additional types—CiliumNetworkPolicy (CNP) and CiliumClusterwideNetworkPolicy (CCN...

Artificial Intelligence Connectedness: Theoretical Reconstruction of Connectedness and Its Impacts on Adolescent Mental Health

The widespread penetration of generative artificial intelligence is reshaping adolescents’ social ecosystems and emotional experiences, while challenging the interpretive boundaries of traditional connectedness theories. Following the logical path of “connotation reconstruction–e...

Hyperactivity in context: comparing actigraphy and informant ratings across the school week

Background Hyperactivity is a core symptom of childhood attention deficit hyperactivity disorder (ADHD), yet no population‐based studies have compared objective and subjective hyperactivity measures across the school day. Methods This study used data from N = 6,518 seven‐year‐old...

Adaptive Eigenvector Continuation for Full-Vector Photonic Waveguide Mode Emulation

Photonic waveguide design often requires repeated full-vector Maxwell eigenmode solves over wavelength, geometry, and material parameters. We present an adaptive eigenvector-continuation framework for accelerating and stabilizing these modal sweeps. The method constructs a reduce...

Entropic Dynamics of Jump-Diffusion Option Pricing

The standard models of stock-price dynamics and option valuation rest on stochastic processes postulated at the outset; here, we lay down an entropic-inference framework that derives these processes rather than assuming them, by making explicit the information each one encodes. A...

Method for Controlling the Exposure of (312) Crystal Plane in Ni12P5 Nanoparticles and Its Impact on the Catalytic Dechlorination Activity of Trichloroethylene

Transition metal phosphides (TMPs) have gained significant attention from researchers in the field of catalytic hydrogenation due to their excellent properties. However, existing studies have rarely explored the targeted regulation of the degree of crystal plane exposure of the N...

Modeling Reliability and Validity Across OSCE Station Numbers in Final MBBS Exam

Background: The Objective Structured Clinical Examination (OSCE) has been the backbone of assessment in medical education, and the number of stations required to achieve sufficient reliability in high-stakes examinations is an important consideration for resource-limited programs...

Exact matrix-free streaming enables global phosphosite co-variation mapping without quadratic result materialization

Reproducibility package for the Scientific Reports revision of the manuscript “Exact matrix-free streaming enables global phosphosite co-variation mapping without quadratic result materialization.” This clean-room package reproduces the principal computational and empirical resul...

Predictive processing as a scalable computational principle for embodied multitask intelligence

Humans exhibit remarkable flexibility in adapting to diverse and uncertain environments—a hallmark arising from the brain’s ability to integrate multimodal sensory streams into coherent predictive models. Drawing on this principle, we introduce a scalable hierarchical multimodal...

Physioxia Reprograms Glioblastoma Cells Enhancing Migration and Altering Therapeutic Sensitivity

Abstract Background/Objectives Glioblastoma is an aggressive primary brain tumor that develops within a chronically low-oxygen microenvironment, yet most preclinical studies are performed under atmospheric oxygen conditions that poorly reflect in vivo physiology. This study inves...

Yu-Shiba-Rusinov-assisted Andreev transport in a molecular junction between superconductors

Magnetic impurities in superconductors host Yu-Shiba-Rusinov (YSR) bound states, whereas weak superconducting junctions sustain subharmonic charge transport through multiple Andreev reflections (MAR). We explore these phenomena using a molecular-scale junction created by placing...

Subclinical Cardiac Dysfunction in Children with Iron Deficiency Anemia Assessed by Tissue Doppler and Speckle-Tracking Echocardiography

OBJECTIVE: Iron deficiency is the leading cause of anemia in childhood and may induce cardiovascular adaptations, including increased heart rate, elevated cardiac output, plasma volume expansion, and myocardial remodeling. Beyond hematologic consequences, reduced iron availabilit...

Endothelin-Dependent Myocardial Dysfunction in an Experimental Endotoxic Shock Model

OBJECTIVE: Impaired myocardial contractility is a major contributor to cardiovascular failure during septic shock; however, the underlying mechanisms remain incompletely understood. This study investigated the roles of endothelin and nitric oxide (NO) in cardiac dysfunction using...

Enhanced extracellular invertase production in Bacillus subtilis by boosting synthesis and secretion in a suitable chassis cell

<title>Abstract</title> Background Soybeans are an important agricultural product, but they contain a significant amount of raffinose, which can cause flatulence when fermented by intestinal microorganisms. Invertase InvDz13 from <italic>Microbacterium trichothecenolyticum</itali...