Research works

Identification of the Down Syndrome Critical Region 3 Gene as a Mammalian Cell Size Regulator

Using a genetic screening approach based on an inducible gene-activating system and cell sorting, Down syndrome critical region 3 (DSCR3) was isolated as a gene whose overexpression increased cell size. Fibroblasts derived from individuals with Down syndrome (DS) exhibit elevated...

Self-Sustaining Quantum Information Engine Operating on Discrete Spacetime Voxels via Toroidal Geodesics and Interaction-Free Measurement

This paper proposes a theoretical model for a self-sustaining Quantum InformationEngine (QIE) operating on discrete, volumetric spacetime at the Planck scale (voxels). Bydirecting photons into toroidal spiral trajectories (toroidal geodesics) within a localizedKerr-metric curvatu...

Complementary Physical Dimensions of Vrancea (Romania) Intermediate-Depth Ground Motions: Intensity Measures and Their Implications for Sustainable Structural and Geotechnical Risk Assessment

Ground-motion intensity measures (IMs) are key parameters for seismic hazard and risk assessment. However, seismic hazard characterization and code-based design spectra commonly rely on a limited set of parameters, particularly peak ground acceleration (PGA), spectral acceleratio...

Assessing the Effects of Root Preparation Methods and Irrigation Strategies for Urban Tree Growth and Establishment

Drought and constrained municipal budgets are increasing demand for establishment practices that conserve water and labor. This study quantified trade-offs between inputs (water, labor, cost) and tree outcomes across irrigation methods and root-ball correction practices during es...

2D hydrodynamical simulations of Be star decretion disc formation through boundary layer effects

Abstract Be stars are massive main-sequence stars rotating close to their breakup rate. They possess a decretion disc of material built up due to mass loss from the star, however, there is not a consensus to the mechanism responsible for the formation of the disc because of their...

Pollinator behaviour and morphology to understand pollination niche partitioning in co‐occurring closely related plant species

Abstract Pollinator foraging behaviour shapes a plant's pollination niche, with direct consequences for natural selection and plant evolution. However, the extent to which individual‐ and species‐level pollinator behaviour, and the drivers of such behaviour, actually influence po...

A Review of Thermal Management in Modern Data Centres: Water Usage Effectiveness and Heat Transfer Coefficients

Rapid growth in artificial intelligence, machine learning, and high-performance computing has substantially increased data centre rack power densities, resulting in higher heat generation and more demanding cooling requirements. As water remains widely used in many cooling system...

Information Loss in Scalar Monetary Aggregation: A Tensorial Langevin Framework for Financial Shock Propagation and Policy Targeting

We develop a tensor-based dynamical framework for monetary flows in multi-sector, multi-agent economies and quantify the information destroyed when the monetary state is reduced to a scalar aggregate. The state is a third-order tensor encoding capital flows across sectors, agent...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Smart Cardiac ICU: Digital Integration, Predictive Analytics, and Perioperative Inflammation

Contemporary intensive care is operating in an environment with high complexity cases, large volumes of information, and vast physiological, biological and therapeutical data, collected from laboratory results, investigations, therapies for organ support, collected from systems t...

Overcoming Perfusion Impairment in the Ischemic Brain: A Review

Perfusion impairment is one of the major barriers to using machine perfusion to prepare brain tissue for research and clinical applications. As ischemia progresses, multiple mechanisms, including intravascular obstructions, perivascular cellular edema, mural cell contraction, and...

Effect of High-Energy Excimer Treatment of Ti-Based Alloys on Cytocompatibility and Antibacterial Properties

The study investigates the effects of high-energy laser treatment on titanium-based alloys, TiAlV, TiNbZr, and TiNbSnTa, materials of high interest for medical applications such as implants and dental devices due to their exceptional strength-to-weight ratio, corrosion resistance...

Impact of the COVID-19 Pandemic on Presentation, Microbiology, and Outcomes of Infective Endocarditis: A Romanian Retrospective Cohort Study

Objectives: This study aimed to assess the impact of the COVID-19 pandemic on the epidemiology, microbiology, clinical presentation, management, and outcomes of infective endocarditis (IE). Methods: A retrospective cohort study was conducted, including 100 adult patients with def...

From Travel Narratives to Cultural Routes: Interpreting via Egnatia as a Heritage Corridor

Cultural Routes have become important instruments for promoting shared heritage and sustainable tourism across Europe, yet the potential of travel literature to inform their development remains underexplored, particularly in the case of Via Egnatia. This study addresses this gap...

Temperature-Dependent Chemical Profiles of Pyroligneous Liquor Fractions from a Kiln-Furnace System

Pyroligneous liquor (PL) is a by-product of charcoal production with potential applications in agriculture, forestry, and industry. This study evaluated the influence of carbonization temperature on the yield, chemical composition, and physicochemical properties of PL obtained fr...

Drone-based assessment of humpback and fin whale vessel-strike vulnerability

Collisions with vessels (vessel-strikes) are one of the largest threats to the recoveries of baleen whale populations worldwide. Vessel-strike vulnerability is complex, depending on a vessels size and speed, and the presence, position, visibility, and movement of whales. To date,...

Quantum pyramidal cosmology: emergent universe from ternary quantum chaos

Comprehensive Edition v9 of Quantum Pyramidal Cosmology (QPC) — a self-consistent model in which the observable Universe emerges from ternary quantum chaos. This edition adds rigorous information-theoretic foundations for the Aura Functional via quantum relative entropy, establis...

Pain as Restrictive Biological Reorganization: A Dynamical Formalization of Action Domain Restriction

Recent naturalistic and enactivist proposals have reinterpreted pain as biological reorganization of the living system, grounded in the Biology of Cognition and non-dualist frameworks that treat pain as a structural modification of the organism rather than a mental representation...

A Moving-Cut Correction to the Huang–Li Conditional Goldbach Argument: Consequences for Diagonal Möbius-Twisted Elliott–Halberstam Hypotheses

This note identifies and repairs a moving-cut omission in the large-divisor rearrangement used in Huang and Li's conditional argument for the binary Goldbach conjecture. Under the substitution k=(N−n)/d, the condition d>α becomes k<(N−n)/α; after reversing the order of summation,...

Agricultural Value Addition and Structural Transformation in a Developing Agrarian Economy: Evidence from Bihar, India

Agricultural value addition and structural transformation are central to sustainable rural development in developing agrarian economies. Although Bihar remains predominantly dependent on agriculture, existing studies have focused mainly on production growth, technological change,...